Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

DSG1

  • Official Full Name

    Desmoglein 1

  • Overview

    Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus.
  • Synonyms

    DSG1; desmoglein 1; DGI; CDHF4; PPKS1; Cadherin family member 4; SPPK1; Desmosomal glycoprotein 1; DSG; Pemphigus foliaceus antigen; desmoglein-1; DG1; OTTHUMP00000162826; DSG2; desmoglein 2; HDGC; CDHF5; ARVC10; ARVD10; CMD1BB; MGC117034; MGC117036; MGC117037; Desmoglein-2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Confidential
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect Cells
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • Myc
  • His|GST
  • SUMO
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DSG1-8319H Recombinant Human DSG1 Mammalian cells N/A
Human DSG1-820H Recombinant Human DSG1 protein, His & GST-tagged E.coli His/GST Glu710~Val961
Human DSG1-2890H Recombinant Human DSG1 Protein, GST-tagged Wheat Germ GST
Human DSG1-1601H Recombinant Human Desmoglein 1 Mammalian cells N/A
Human DSG1-26581TH Recombinant Human DSG1 Wheat Germ N/A 1049 amino acids
Human DSG1-12178H Recombinant Human DSG1 protein, His-tagged E.coli His 756-1049 aa
Human DSG1-512HCL Recombinant Human DSG1 cell lysate N/A
Human DSG1-144HF Recombinant Full Length Human DSG1 Protein In Vitro Cell Free System 1049 amino acids
Human DSG1-1994H Recombinant Human DSG1 Protein (Glu50-Pro548), N-His tagged E.coli N-His Glu50-Pro548
Human DSG1-2458H Recombinant Human DSG1 protein, His-SUMO & Myc-tagged E.coli His-SUMO & Myc 50-548aa
Human DSG1-2457H Recombinant Human DSG1 protein, His&Myc-tagged E.coli His&Myc 50-548aa
Human DSG1-4254HF Recombinant Full Length Human DSG1 Protein, GST-tagged In Vitro Cell Free System GST 1049 amino acids
Human DSG1-1388H Recombinant Human DSG1 Protein, His-tagged E.coli N-His Glu710-Val961
Human DSG1-4389H-B Recombinant Human DSG1 Protein Pre-coupled Magnetic Beads HEK293
Human DSG1-4389H Recombinant Human DSG1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DSG1-4067H Recombinant Human DSG1 Protein (Glu50-Pro548), C-His tagged Mammalian cells C-His Glu50-Pro548
Human DSG1-0269H Recombinant Human DSG1 Protein, Tag Free Confidential Tag Free
Human DSG1-4066H Recombinant Human DSG1 Protein (Glu50-Pro548), C-His tagged Insect Cells C-His Glu50-Pro548
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DSG1 Related Articles
  • DSG1 Related Research Area

DSG1 involved in several pathways and played different roles in them. We selected most pathways DSG1 participated on our site, such as Apoptosis, Apoptotic cleavage of cell adhesion proteins, Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DSG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ApoptosisHRK;ATM;PPP3CB;PPP3R2;BAXA;RIPK1;IL1B2;CAPN2B;PRKACBA
Apoptotic cleavage of cell adhesion proteinsOCLN;DSG2;DSP;PKP1;CTNNB1;DSG3;PTBP3;CTNNB2;DSG1
Apoptotic cleavage of cellular proteinsPLEC;VIML;LMNB1;DSG2;BMX;OCLN;STK26;CTNNB1;STK24
Apoptotic execution phaseDBNL;GAS2;HIST1H1E;HIST1H1A;DNM1L;CASP6L1;HIST1H1D;PTBP3;CTNNB1
Programmed Cell DeathDSP;DIABLOB;HMGB2A;DBNL;Gzmg;CASP6L1;HMGB2;DAPK3;GAS2
Staphylococcus aureus infectionHLA-DRA;ITGAM;FCGR3A;HLA-DRB3;FCGR1A;C1R;ITGB2;SELPLG;FCGR1

DSG1 has several biochemical functions, for example, calcium ion binding, gamma-catenin binding, toxic substance binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DSG1 itself. We selected most functions DSG1 had, and list some proteins which have the same functions with DSG1. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingPCDH1G22;AP1S2;AOC3;SYTL4;CDH12;THBS4B;PRSS2;FLG;SYT12
gamma-catenin bindingAPC2;CTNNA1;CDH1;LEF1;PTPRJ;APC;DSG1;Fert2;FER
toxic substance bindingAZU1;H2-AB1;CHRNA7;GUCY2C;Alb;EPHX2;DSG1;ASS1;NEFH

DSG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DSG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DSG1.

SSSCA1; USP1; GH1; OTUD4; USP53; VRK3; q9nz47_human; RUVBL1; midostaurin; cona_canen; ESR1; CFTR; IQGAP1; PLK1; CD81; GABARAPL2; PPP2R2B; MAPK7; IQCB1

Aoki, V; Rivitti, EA; et al. Update on fogo selvagem, an endemic form of pemphigus foliaceus. JOURNAL OF DERMATOLOGY 42:18-26(2015).
Kinjyo, C; Kaneko, T; et al. Oral lichen planus with antibodies to desmogleins 1 and 3. JOURNAL OF DERMATOLOGY 42:40-41(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How is DSG1 expression regulated in the skin? 08/06/2021

Various factors, including cytokines and growth factors, can regulate the expression of DSG1 in skin cells.

Are there any clinical trials focused on DSG1 protein therapies? 11/17/2020

Some clinical trials may be exploring DSG1-based therapies for skin disorders, but you should consult clinical trial databases for specific information.

What other medical conditions are associated with DSG1 protein? 08/15/2020

DSG1 abnormalities are primarily linked to skin disorders, but some studies suggest potential connections to oral mucosa disorders.

Can DSG1 be used as a biomarker for skin cancer? 04/14/2018

While DSG1 is not a direct biomarker for skin cancer, its expression levels may be altered in some skin cancers.

Can DSG1-targeted therapies be used to treat skin conditions? 11/30/2016

Research is ongoing, but DSG1-targeted therapies have the potential to treat conditions related to DSG1 deficiencies.

Customer Reviews (3)

Write a review
Reviews
02/22/2023

    Its impeccable purity and integrity make it a valuable asset in my research endeavors.

    03/02/2022

      Their team of experts has been instrumental in resolving any queries or challenges I encountered regarding the application and utilization of the DSG1 protein.

      03/22/2021

        The DSG1 protein surpasses expectations in terms of quality and is an ideal match for my experimental requirements.

        Ask a Question for All DSG1 Products

        Required fields are marked with *

        My Review for All DSG1 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends