DSG1
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Official Full Name
Desmoglein 1
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Overview
Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus. -
Synonyms
DSG1; desmoglein 1; DGI; CDHF4; PPKS1; Cadherin family member 4; SPPK1; Desmosomal glycoprotein 1; DSG; Pemphigus foliaceus antigen; desmoglein-1; DG1; OTTHUMP00000162826; DSG2; desmoglein 2; HDGC; CDHF5; ARVC10; ARVD10; CMD1BB; MGC117034; MGC117036; MGC117037; Desmoglein-2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Confidential
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect Cells
- Mammalian cells
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- Myc
- His|GST
- SUMO
- N/A
- N
- Tag Free
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | DSG1-8319H | Recombinant Human DSG1 | Mammalian cells | N/A | ||
Human | DSG1-820H | Recombinant Human DSG1 protein, His & GST-tagged | E.coli | His/GST | Glu710~Val961 | |
Human | DSG1-2890H | Recombinant Human DSG1 Protein, GST-tagged | Wheat Germ | GST | ||
Human | DSG1-1601H | Recombinant Human Desmoglein 1 | Mammalian cells | N/A | ||
Human | DSG1-26581TH | Recombinant Human DSG1 | Wheat Germ | N/A | 1049 amino acids | |
Human | DSG1-12178H | Recombinant Human DSG1 protein, His-tagged | E.coli | His | 756-1049 aa | |
Human | DSG1-512HCL | Recombinant Human DSG1 cell lysate | N/A | |||
Human | DSG1-144HF | Recombinant Full Length Human DSG1 Protein | In Vitro Cell Free System | 1049 amino acids | ||
Human | DSG1-1994H | Recombinant Human DSG1 Protein (Glu50-Pro548), N-His tagged | E.coli | N-His | Glu50-Pro548 | |
Human | DSG1-2458H | Recombinant Human DSG1 protein, His-SUMO & Myc-tagged | E.coli | His-SUMO & Myc | 50-548aa | |
Human | DSG1-2457H | Recombinant Human DSG1 protein, His&Myc-tagged | E.coli | His&Myc | 50-548aa | |
Human | DSG1-4254HF | Recombinant Full Length Human DSG1 Protein, GST-tagged | In Vitro Cell Free System | GST | 1049 amino acids | |
Human | DSG1-1388H | Recombinant Human DSG1 Protein, His-tagged | E.coli | N-His | Glu710-Val961 | |
Human | DSG1-4389H-B | Recombinant Human DSG1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | DSG1-4389H | Recombinant Human DSG1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | DSG1-4067H | Recombinant Human DSG1 Protein (Glu50-Pro548), C-His tagged | Mammalian cells | C-His | Glu50-Pro548 | |
Human | DSG1-0269H | Recombinant Human DSG1 Protein, Tag Free | Confidential | Tag Free | ||
Human | DSG1-4066H | Recombinant Human DSG1 Protein (Glu50-Pro548), C-His tagged | Insect Cells | C-His | Glu50-Pro548 |
- Involved Pathway
- Protein Function
- Interacting Protein
- DSG1 Related Articles
- DSG1 Related Research Area
DSG1 involved in several pathways and played different roles in them. We selected most pathways DSG1 participated on our site, such as Apoptosis, Apoptotic cleavage of cell adhesion proteins, Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DSG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Apoptosis | HRK;ATM;PPP3CB;PPP3R2;BAXA;RIPK1;IL1B2;CAPN2B;PRKACBA |
Apoptotic cleavage of cell adhesion proteins | OCLN;DSG2;DSP;PKP1;CTNNB1;DSG3;PTBP3;CTNNB2;DSG1 |
Apoptotic cleavage of cellular proteins | PLEC;VIML;LMNB1;DSG2;BMX;OCLN;STK26;CTNNB1;STK24 |
Apoptotic execution phase | DBNL;GAS2;HIST1H1E;HIST1H1A;DNM1L;CASP6L1;HIST1H1D;PTBP3;CTNNB1 |
Programmed Cell Death | DSP;DIABLOB;HMGB2A;DBNL;Gzmg;CASP6L1;HMGB2;DAPK3;GAS2 |
Staphylococcus aureus infection | HLA-DRA;ITGAM;FCGR3A;HLA-DRB3;FCGR1A;C1R;ITGB2;SELPLG;FCGR1 |
DSG1 has several biochemical functions, for example, calcium ion binding, gamma-catenin binding, toxic substance binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DSG1 itself. We selected most functions DSG1 had, and list some proteins which have the same functions with DSG1. You can find most of the proteins on our site.
Function | Related Protein |
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calcium ion binding | PCDH1G22;AP1S2;AOC3;SYTL4;CDH12;THBS4B;PRSS2;FLG;SYT12 |
gamma-catenin binding | APC2;CTNNA1;CDH1;LEF1;PTPRJ;APC;DSG1;Fert2;FER |
toxic substance binding | AZU1;H2-AB1;CHRNA7;GUCY2C;Alb;EPHX2;DSG1;ASS1;NEFH |
DSG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DSG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DSG1.
SSSCA1; USP1; GH1; OTUD4; USP53; VRK3; q9nz47_human; RUVBL1; midostaurin; cona_canen; ESR1; CFTR; IQGAP1; PLK1; CD81; GABARAPL2; PPP2R2B; MAPK7; IQCB1
- Q&As
- Reviews
Q&As (5)
Ask a questionVarious factors, including cytokines and growth factors, can regulate the expression of DSG1 in skin cells.
Some clinical trials may be exploring DSG1-based therapies for skin disorders, but you should consult clinical trial databases for specific information.
DSG1 abnormalities are primarily linked to skin disorders, but some studies suggest potential connections to oral mucosa disorders.
While DSG1 is not a direct biomarker for skin cancer, its expression levels may be altered in some skin cancers.
Research is ongoing, but DSG1-targeted therapies have the potential to treat conditions related to DSG1 deficiencies.
Customer Reviews (3)
Write a reviewIts impeccable purity and integrity make it a valuable asset in my research endeavors.
Their team of experts has been instrumental in resolving any queries or challenges I encountered regarding the application and utilization of the DSG1 protein.
The DSG1 protein surpasses expectations in terms of quality and is an ideal match for my experimental requirements.
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