Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

DSG2

  • Official Full Name

    desmoglein 2

  • Overview

    Desmoglein 2, also known as DSG2, is a human gene. Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 2 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epitheli
  • Synonyms

    DSG2; desmoglein 2; desmoglein-2; CDHF5; HDGC; cadherin family member 5; ARVC10; ARVD10; CMD1BB; MGC117034; MGC117036; MGC117037;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cell
  • Mammalian cells
  • Fc
  • Fc Chimera
  • His
  • His (Fc)
  • Avi
  • Myc
  • SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DSG2-512H Active Recombinant Human DSG2, Fc Chimera Mammalian cells Fc Chimera
Human DSG2-1601H Recombinant Human Desmoglein 2 Mammalian cells N/A
Human DSG2-6807HCL Recombinant Human DSG2 293 Cell Lysate HEK293 N/A
Human DSG2-400H Recombinant Human DSG2 Protein, His-tagged E.coli His Lys275~Val533
Human DSG2-510H Active Recombinant Human DSG2 protein, His-tagged HEK293 His Ala50-Gly609
Human DSG2-4426H Recombinant Human DSG2 protein, His&Myc-tagged E.coli His&Myc 50-609aa
Human DSG2-181H-B Recombinant Human DSG2 Protein Pre-coupled Magnetic Beads HEK293
Human DSG2-181H Recombinant Human DSG2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Dsg2-41M Active Recombinant Mouse Dsg2, Fc-tagged Mammalian cells Fc
Mouse Dsg2-990M Active Recombinant Mouse Dsg2 Protein, Fc Chimera Mammalian cells Fc
Mouse Dsg2-56M Recombinant Mouse Dsg2 Protein E.coli N/A
Mouse DSG2-4842M Recombinant Mouse DSG2 Protein Mammalian Cell His
Mouse DSG2-2540M Recombinant Mouse DSG2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DSG2-2540M-B Recombinant Mouse DSG2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Dsg2-2824M Recombinant Mouse Dsg2 protein, His-SUMO-tagged E.coli His-SUMO 55-618aa
Mouse Dsg2-40M Recombinant Mouse Dsg2 protein, His-tagged HEK293 His Ala55-Ala618
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DSG2 Related Articles
  • DSG2 Related Research Area

DSG2 involved in several pathways and played different roles in them. We selected most pathways DSG2 participated on our site, such as Apoptosis, Apoptotic cleavage of cell adhesion proteins, Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DSG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ApoptosisCDKN2A;DFFB;PIK3R3B;ENDOG;TNFRSF1A;DBNLB;PRKAR1AB;IL1A;CTNNB2
Apoptotic cleavage of cell adhesion proteinsDSG2;CTNNB2;OCLN;CTNNB1;PKP1;DSG3;DSG1;DSP;PTBP3
Apoptotic cleavage of cellular proteinsCASP6L1;BMX;PKP1;CASP6L2;CTNNB2;GAS2;SATB1;BCAP31;DSP
Apoptotic execution phaseCTNNB1;STK24A;LMNB1;PLECA;DSP;PLEC;PANK1A;STK24;STK24B
Arrhythmogenic right ventricular cardiomyopathyCDH2;CACNG3;CTNNA1;CACNG2;DSC2;CTNNA2;DMD;DSP;DAG1
Arrhythmogenic right ventricular cardiomyopathy (ARVC)ITGA3;Itga10&Itgb1;ITGB6;ACTB;ITGB4;ITGA6;DMD;CTNNA1;ATP2A2
Programmed Cell DeathGZME;VIML;DSG2;BAXB;HMGB2A;BCAP31;DNM1L;PKP1;ADD1

DSG2 has several biochemical functions, for example, calcium ion binding, cell adhesion molecule binding, cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication. Some of the functions are cooperated with other proteins, some of the functions could acted by DSG2 itself. We selected most functions DSG2 had, and list some proteins which have the same functions with DSG2. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingPCDH1GB9;LDLRB;SGCA;AOC3;ANKRD5;PCDH1G1;MCTP1;EPD;CIB1
cell adhesion molecule bindingGRIN2A;PVRL1;EZR;JUP;LILRB2;SDCBP;ITGA4;TENM2;AMICA1
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communicationDSP;CTNNA3;DSC2;DSG2;JUP;PKP2

DSG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DSG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DSG2.

ganglioside_gm1; JUP; Cbx1; DSC2; Trim69; Flot1; PDGFRA; FLNA; MYH9; Bmpr1a; IQGAP1; Tpm1; Actb; ACTR2; Ppp1cb; Jup; DBN1

Espana, A; Koga, H; et al. Antibodies to the amino-terminal domain of desmoglein 1 are retained during transition from pemphigus vulgaris to pemphigus foliaceus. EUROPEAN JOURNAL OF DERMATOLOGY 24:174-179(2014).
Toumi, A; Saleh, MA; et al. Autoimmune reactivity against precursor form of desmoglein 1 in healthy Tunisians in the area of endemic pemphigus foliaceus. JOURNAL OF DERMATOLOGICAL SCIENCE 70:19-25(2013).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does Desmoglein-2 contribute to wound healing and tissue repair, and are there therapeutic implications for manipulating its activity in these processes? 01/07/2022

Desmoglein-2 plays a role in wound healing and tissue repair by facilitating cell adhesion and migration. Manipulating its activity may have therapeutic implications for enhancing these processes.

How is the expression of Desmoglein-2 regulated, and what are the consequences of its dysregulation in the context of autoimmune diseases and skin disorders? 02/28/2021

Desmoglein-2 expression is regulated at transcriptional and post-translational levels. Dysregulation is linked to autoimmune diseases like pemphigus, where autoantibodies target Desmoglein-2, leading to skin blistering.

Can you elaborate on the molecular structure of Desmoglein-2 and its interactions within desmosomal complexes? 09/15/2020

Desmoglein-2 has a unique molecular structure with extracellular domains facilitating cell-cell adhesion. It interacts with other desmosomal components, such as Desmocollins and Plakoglobin, forming strong intercellular junctions.

How does Desmoglein-2 contribute to the regulation of cell signaling pathways, and are there specific pathways influenced by its interactions with other cellular components? 05/08/2019

Desmoglein-2 participates in cell signaling, impacting pathways involved in cell adhesion, migration, and survival. Its interactions with other desmosomal components modulate signaling cascades essential for cellular function.

Can you discuss the role of Desmoglein-2 in epithelial-mesenchymal transition (EMT) and its implications for cancer invasion and metastasis? 11/23/2018

Desmoglein-2 influences EMT, a process crucial for cancer invasion and metastasis. Changes in Desmoglein-2 expression and localization contribute to alterations in cell adhesion dynamics during EMT.

Customer Reviews (3)

Write a review
Reviews
05/05/2021

    Unmatched product superiority, professional customer service, and delivery that exceeded expectations.

    02/01/2019

      A truly delightful buying experience.

      07/17/2018

        This lab product excels in quality, backed by a customer service team that is not only friendly but also knowledgeable.

        Ask a Question for All DSG2 Products

        Required fields are marked with *

        My Review for All DSG2 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends