DSG2
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Official Full Name
desmoglein 2
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Overview
Desmoglein 2, also known as DSG2, is a human gene. Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 2 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epitheli -
Synonyms
DSG2; desmoglein 2; desmoglein-2; CDHF5; HDGC; cadherin family member 5; ARVC10; ARVD10; CMD1BB; MGC117034; MGC117036; MGC117037;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- Mammalian Cell
- Mammalian cells
- Fc
- Fc Chimera
- His
- His (Fc)
- Avi
- Myc
- SUMO
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- DSG2 Related Articles
- DSG2 Related Research Area
DSG2 involved in several pathways and played different roles in them. We selected most pathways DSG2 participated on our site, such as Apoptosis, Apoptotic cleavage of cell adhesion proteins, Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DSG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Apoptosis | CDKN2A;DFFB;PIK3R3B;ENDOG;TNFRSF1A;DBNLB;PRKAR1AB;IL1A;CTNNB2 |
Apoptotic cleavage of cell adhesion proteins | DSG2;CTNNB2;OCLN;CTNNB1;PKP1;DSG3;DSG1;DSP;PTBP3 |
Apoptotic cleavage of cellular proteins | CASP6L1;BMX;PKP1;CASP6L2;CTNNB2;GAS2;SATB1;BCAP31;DSP |
Apoptotic execution phase | CTNNB1;STK24A;LMNB1;PLECA;DSP;PLEC;PANK1A;STK24;STK24B |
Arrhythmogenic right ventricular cardiomyopathy | CDH2;CACNG3;CTNNA1;CACNG2;DSC2;CTNNA2;DMD;DSP;DAG1 |
Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ITGA3;Itga10&Itgb1;ITGB6;ACTB;ITGB4;ITGA6;DMD;CTNNA1;ATP2A2 |
Programmed Cell Death | GZME;VIML;DSG2;BAXB;HMGB2A;BCAP31;DNM1L;PKP1;ADD1 |
DSG2 has several biochemical functions, for example, calcium ion binding, cell adhesion molecule binding, cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication. Some of the functions are cooperated with other proteins, some of the functions could acted by DSG2 itself. We selected most functions DSG2 had, and list some proteins which have the same functions with DSG2. You can find most of the proteins on our site.
Function | Related Protein |
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calcium ion binding | PCDH1GB9;LDLRB;SGCA;AOC3;ANKRD5;PCDH1G1;MCTP1;EPD;CIB1 |
cell adhesion molecule binding | GRIN2A;PVRL1;EZR;JUP;LILRB2;SDCBP;ITGA4;TENM2;AMICA1 |
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication | DSP;CTNNA3;DSC2;DSG2;JUP;PKP2 |
DSG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DSG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DSG2.
ganglioside_gm1; JUP; Cbx1; DSC2; Trim69; Flot1; PDGFRA; FLNA; MYH9; Bmpr1a; IQGAP1; Tpm1; Actb; ACTR2; Ppp1cb; Jup; DBN1
- Q&As
- Reviews
Q&As (5)
Ask a questionDesmoglein-2 plays a role in wound healing and tissue repair by facilitating cell adhesion and migration. Manipulating its activity may have therapeutic implications for enhancing these processes.
Desmoglein-2 expression is regulated at transcriptional and post-translational levels. Dysregulation is linked to autoimmune diseases like pemphigus, where autoantibodies target Desmoglein-2, leading to skin blistering.
Desmoglein-2 has a unique molecular structure with extracellular domains facilitating cell-cell adhesion. It interacts with other desmosomal components, such as Desmocollins and Plakoglobin, forming strong intercellular junctions.
Desmoglein-2 participates in cell signaling, impacting pathways involved in cell adhesion, migration, and survival. Its interactions with other desmosomal components modulate signaling cascades essential for cellular function.
Desmoglein-2 influences EMT, a process crucial for cancer invasion and metastasis. Changes in Desmoglein-2 expression and localization contribute to alterations in cell adhesion dynamics during EMT.
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