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DUSP11

  • Official Full Name

    dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)

  • Overview

    The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism.
  • Synonyms

    DUSP11; dual specificity phosphatase 11 (RNA/RNP complex 1-interacting); RNA/RNP complex-1-interacting phosphatase; PIR1; Dual specificity protein phosphatase 11; Phosphatase that interacts with RNA/RNP complex 1; RNA/RNP complex interacting phosphatase; RNA/RNP complex1 intereracting phosphatase; Serine/threonine specific protein phosphatase; RNA/RNP complex-interacting phosphatase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DUSP11-2923H Recombinant Human DUSP11 Protein, GST-tagged Wheat Germ GST
Human DUSP11-12204H Recombinant Human DUSP11, GST-tagged E.coli GST 1-203a.a.
Human DUSP11-640H Recombinant Human DUSP11 Protein, His-tagged E.coli His
Human DUSP11-6783HCL Recombinant Human DUSP11 293 Cell Lysate HEK293 N/A
Human DUSP11-4090HF Recombinant Full Length Human DUSP11 Protein, GST-tagged In Vitro Cell Free System GST 330 amino acids
Human DUSP11-3066H Recombinant Human DUSP11 protein, His-tagged E.coli His 1-203 aa
Human DUSP11-2236H Recombinant Human DUSP11 Protein (Gly75-Trp255), N-His tagged E.coli N-His Gly75-Trp255
Mouse DUSP11-4876M Recombinant Mouse DUSP11 Protein Mammalian Cell His
Mouse DUSP11-2563M Recombinant Mouse DUSP11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DUSP11-2563M-B Recombinant Mouse DUSP11 Protein Pre-coupled Magnetic Beads HEK293
Rat DUSP11-1972R Recombinant Rat DUSP11 Protein Mammalian Cell His
Rat DUSP11-1631R Recombinant Rat DUSP11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DUSP11-1631R-B Recombinant Rat DUSP11 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DUSP11-2477Z Recombinant Zebrafish DUSP11 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DUSP11 Related Articles

DUSP11 involved in several pathways and played different roles in them. We selected most pathways DUSP11 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

DUSP11 has several biochemical functions, for example, RNA binding, nucleotide phosphatase activity, acting on free nucleotides, phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP11 itself. We selected most functions DUSP11 had, and list some proteins which have the same functions with DUSP11. You can find most of the proteins on our site.

Function Related Protein
RNA bindingADAD2;RPLP2;LRPPRC;TIAL1;CAPRIN1;PPP5C;HSP90B1;RCAN3;PSMA1
nucleotide phosphatase activity, acting on free nucleotidesDUSP11;NTPCR;NUDT16;PGP
phosphatase activityPTPRUB;MTMR1A;PGAM5;CTDSPLB;MINPP1B;EPHX2;PTPN2A;DUSP19B;DUSP23A
poly(A) RNA bindingEIF4B;CPSF4;RPS27L;PPIG;NUCKS1;CD3EAP;RPL22;SF3B2;RPUSD4
polynucleotide 5-phosphatase activityRNGTT;DUSP11
protein tyrosine phosphatase activityPTPRJ;CDC14AA;CDC14B;MTMR7A;EPM2A;PTPN2;CDC14A;DUSP4;DUSP10
protein tyrosine/serine/threonine phosphatase activityCDKN3;DUSP2;TPTE;DUSP23A;LRP8;PTPDC1;SSH2;CDC14AB;CTDSPL2B

DUSP11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP11 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP11.

QARS; HNRNPA1; KIF11; Csde1; THOC1

Abers, HMHG; Kuijl, C; et al. Integrating Chemical and Genetic Silencing Strategies To Identify Host Kinase-Phosphatase Inhibitor Networks That Control Bacterial Infection. ACS CHEMICAL BIOLOGY 9:414-422(2014).
Nallaparaju, KC; Zhang, YL; et al. DUSP11 is a critical regulator of innate immune responses mediated by dendritic cells. CYTOKINE 63:286-286(2013).
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