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DUSP16

  • Official Full Name

    dual specificity phosphatase 16

  • Overview

    This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.
  • Synonyms

    DUSP16; dual specificity phosphatase 16; dual specificity protein phosphatase 16; KIAA1700; MAPK phosphatase 7; MKP 7; MKP7; MAPK phosphatase-7; MAP kinase phosphatase 7; mitogen-activated protein kinase phosphatase 7; MKP-7; FLJ36298; FLJ40991; MGC129701;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DUSP16-102H Recombinant Human DUSP16, GST-tagged E.coli GST
Human DUSP16-101H Recombinant Human DUSP16, GST-tagged Wheat Germ GST
Zebrafish DUSP16-12442Z Recombinant Zebrafish DUSP16 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DUSP16 Related Articles

DUSP16 involved in several pathways and played different roles in them. We selected most pathways DUSP16 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayMAP3K3;CD14;SRFA;PPM1A;ZAK;NTRK2;RAP1A;TRAF2;MAP3K11

DUSP16 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP16 itself. We selected most functions DUSP16 had, and list some proteins which have the same functions with DUSP16. You can find most of the proteins on our site.

Function Related Protein
MAP kinase tyrosine/serine/threonine phosphatase activityDUSP7;DUSP21;DUSP6;SGPP2;DUSP9;DUSP10;DUSP18;SACM1LB;NT5DC3
phosphoprotein phosphatase activityPHPT1;DUSP22A;CTDSPL2A;CTDNEP1;PTPRJA;PHLPP1;CDC14A;PPP3CB;CTDNEP1A
protein tyrosine phosphatase activityMTMR1;PTP4A1;DUSP22A;DUSP26;CDKN3;PTPRK;MTMR6;DUSP14;DUSP22
protein tyrosine/serine/threonine phosphatase activityDUSP10;DUSP12;LRP8;EYA3;SSH2;CDC14B;DUSP23;DUSP23A;DUSP19B

DUSP16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP16 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP16.

MAPK14

Park, H; Park, SY; et al. Discovery of Novel DUSP16 Phosphatase Inhibitors through Virtual Screening with Homology Modeled Protein Structure. JOURNAL OF BIOMOLECULAR SCREENING 19:1383-1390(2014).
Feurstein, S; Rucker, FG; et al. Haploinsufficiency of ETV6 and CDKN1B in patients with acute myeloid leukemia and complex karyotype. BMC GENOMICS 15:-(2014).
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