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DUSP2

  • Official Full Name

    dual specificity phosphatase 2

  • Overview

    The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily.These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus.
  • Synonyms

    DUSP2; dual specificity phosphatase 2; dual specificity protein phosphatase 2; PAC 1; Dual specificity protein phosphatase PAC 1; DUSP 2; PAC1; Serine/threonine specific protein phosphatase; OTTHUMP00000161013; dual-specificity phosphatase 2; dual specificity protein phosphatase PAC-1; PAC-1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DUSP2-101H Recombinant Human DUSP2, GST-tagged Wheat Germ GST
Human DUSP2-45H Recombinant Human DUSP2 protein, His-tagged E.coli His 185aa(including fusion tag)
Human DUSP2-132HF Recombinant Full Length Human DUSP2 Protein, GST-tagged In Vitro Cell Free System GST 1 a.a. - 314 a.a.
Mouse DUSP2-4883M Recombinant Mouse DUSP2 Protein Mammalian Cell His
Mouse DUSP2-2566M Recombinant Mouse DUSP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DUSP2-2566M-B Recombinant Mouse DUSP2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DUSP2-898Z Recombinant Zebrafish DUSP2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DUSP2 involved in several pathways and played different roles in them. We selected most pathways DUSP2 participated on our site, such as ARMS-mediated activation, Axon guidance, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ARMS-mediated activationPSMA8;HBEGF;SPRED1;PSMD10;SPTBN2;PAQR3A;CSF2RA;PSMD9;DLG4
Axon guidanceRHOC;MAPK3;RND1;RAC2;PAQR3A;SPTBN2;RND1L;KALRN;CSF2RA
Cytokine Signaling in Immune systemTRIM68;TRIM2;NOD1;PTPRA;TNFRSF13C;PEA15;IFIT3;NEFLB;HAVCR2
DAP12 interactionsPTPRA;DUSP4;FGF18B;DUSP7;SPRED2;DUSP9;KIR3DS1;SPNA2;GRAP2A
DAP12 signalingNRG4;MARK3;THEM4;SPTBN1;DUSP5;CSF2RB;FRS2;FGF18B;NRG2A
Developmental BiologyMYL12A;JAK3;KDR;ITGB3A;ARPC1A;FRS3;PTPRA;DCC;SCN2A
Downstream signal transductionFRS2A;SPTA1;RASGEF1A;DUSP9;CRKL;DAB2IPB;WDR83;TRAT1;AGO1
Downstream signaling of activated FGFR1SPRED2;PEA15;PTPRA;SPTA1;IL17RD;DAB2IPB;CNKSR1;DUSP9;MARK3

DUSP2 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, mitogen-activated protein kinase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP2 itself. We selected most functions DUSP2 had, and list some proteins which have the same functions with DUSP2. You can find most of the proteins on our site.

Function Related Protein
MAP kinase tyrosine/serine/threonine phosphatase activityDUSP16;DUSP1;PXYLP1;CTDSPL2B;NT5DC3;TENC1;DUSP14;DUSP2;DUSP9
mitogen-activated protein kinase bindingMAPKAPK2;CDK5RAP3;DUSP2;ARRB2;TPR;ATF7;PTPRJ;MAPKAPK2B;MAPK7
protein bindingTHAP10;AURKB;DDX21;BMPR2;TP63;RBM4;CXorf41;ASTE1;SMYD2
protein tyrosine phosphatase activityMTMR14;LRP8;PTPN11B;PTPRK;EYA3;PTPRU;DUSP11;MTMR7B;MTMR1A
protein tyrosine/serine/threonine phosphatase activitySACM1LB;NT5DC3;SSH2B;LRP8;DUSP3;PXYLP1;PTP4A2B;SGPP2;DUSP1
protein tyrosine/threonine phosphatase activityTENC1;SGPP2;NT5DC3;CTDSPL2A;SACM1LB;CTDSPL2B;PXYLP1;DUSP2;SACM1LA

DUSP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP2.

MAPK3; MAPK1

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