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DUSP9

  • Official Full Name

    dual specificity phosphatase 9

  • Overview

    The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus.
  • Synonyms

    DUSP9; dual specificity phosphatase 9; dual specificity protein phosphatase 9; map kinase phosphatase 4; MKP 4; MKP4; serine/threonine specific protein phosphatase; mitogen-activated protein kinase phosphatase 4; MKP-4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DUSP9-2948H Recombinant Human DUSP9 Protein, GST-tagged Wheat Germ GST
Human DUSP9-12220H Recombinant Human DUSP9, His-tagged E.coli His 1-381a.a.
Human DUSP9-6769HCL Recombinant Human DUSP9 293 Cell Lysate HEK293 N/A
Human DUSP9-2010H Recombinant Human DUSP9 Protein (Met1-Thr384), N-His tagged E.coli N-His Met1-Thr384
Human DUSP9-5092H Recombinant Human DUSP9 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DUSP9-4122HF Recombinant Full Length Human DUSP9 Protein, GST-tagged In Vitro Cell Free System GST 384 amino acids
Mouse Dusp9-2692M Recombinant Mouse Dusp9 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque DUSP9-1357R Recombinant Rhesus monkey DUSP9 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DUSP9-1182R-B Recombinant Rhesus Macaque DUSP9 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DUSP9-1182R Recombinant Rhesus Macaque DUSP9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DUSP9 involved in several pathways and played different roles in them. We selected most pathways DUSP9 participated on our site, such as ARMS-mediated activation, Axon guidance, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ARMS-mediated activationCNKSR1;FGFR1B;FGF8B;RASGRP4;SPNA1;SPTA1;FRS2A;RASGRP1;KLB
Axon guidanceSema3f;AP2A2;UNC5C;FRS2A;EPHB4;RHOGA;RGMA;SRGAP2;CAP2
Cytokine Signaling in Immune systemTRIM2;TRIM22;DUSP2;IFIT8;HBEGF;XAF1;CSF2RB;CSF2RA;ISG20
DAP12 interactionsSPTB;PHB;HBEGF;FGF18B;DUSP1;KBTBD7;KIR3DS1;PEA15;NEFLB
DAP12 signalingPAQR3B;CNKSR1;FRS2;DUSP5;JAK1;AGO3;SPTBN2;RASGRP1;TRAT1
Developmental BiologyMED23;KCNQ3;ARHGEF28;DUSP1;GDF1;LEFTY1;GDNF;POU5F3;PRDM14
Downstream signal transductionMOV10;KBTBD7;MARK3;PAQR3A;TRAT1;THEM4;JAK1;IL17RD;FGFR1B
Downstream signaling of activated FGFR1RASGRP4;SPRED1;DUSP2;PEA15A;PAQR3A;KBTBD7;PAQR3B;PEA15;SPTB

DUSP9 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, phosphoprotein phosphatase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP9 itself. We selected most functions DUSP9 had, and list some proteins which have the same functions with DUSP9. You can find most of the proteins on our site.

Function Related Protein
MAP kinase tyrosine/serine/threonine phosphatase activityDUSP8A;DUSP9;SACM1LA;DUSP18;DUSP14;DUSP5;DUSP16;PTPRQ;SACM1LB
phosphoprotein phosphatase activityCDC25D;DUSP26;PTEN;CTDNEP1A;PPP2CA;PPP1CBL;PTPN23A;PHPT1;PTPRJA
protein bindingIQUB;RIN3;RHPN1;ZNF649;WHRN;CSRP2BP;Fgf15;MOB4;SENP6
protein tyrosine phosphatase activityPTPRM;CDC25C;MDP1;MTMR3;PTPRA;DUSP23B;MTMR1;DUSP12;EVLA
protein tyrosine/serine/threonine phosphatase activityDUSP8A;RNGTT;DUSP22B;DUSP14;DUSP13;CDC14B;CDC14AB;DUSP23B;DUSP10

DUSP9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP9 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP9.

Mapk14; MAPK14; MAPK3; MAPK1; CDK4; GSK3B; Mapk1; Mapk3; STK4; MAPK11

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