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DUX4

  • Official Full Name

    double homeobox 4

  • Overview

    This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that contains two homeoboxes; the repeat-array and ORF is conserved in other mammals. There was no evidence for transcription from standard cDNA libraries however RTPCR and in-vitro expression experiments indicate that the ORF is transcribed and the encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the microsatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD).
  • Synonyms

    DUX4; double homeobox 4; double homeobox protein 4; double homeobox protein 10; double homeobox protein 4/10; double homeobox protein DUX10; DUX10;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DUX4-2957H Recombinant Human DUX4 Protein, GST-tagged Wheat Germ GST
Human DUX4-2958H Active Recombinant Human DUX4 Protein, GST-tagged E.coli GST 263-424 aa
Human DUX4-5857H Recombinant Human DUX4 protein, His-tagged E.coli His 327-424aa
Human DUX4-4133HF Recombinant Full Length Human DUX4 Protein, GST-tagged In Vitro Cell Free System GST 424 amino acids
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