DUX4
-
Official Full Name
double homeobox 4
-
Overview
This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that contains two homeoboxes; the repeat-array and ORF is conserved in other mammals. There was no evidence for transcription from standard cDNA libraries however RTPCR and in-vitro expression experiments indicate that the ORF is transcribed and the encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the microsatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). -
Synonyms
DUX4; double homeobox 4; double homeobox protein 4; double homeobox protein 10; double homeobox protein 4/10; double homeobox protein DUX10; DUX10;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | DUX4-2957H | Recombinant Human DUX4 Protein, GST-tagged | Wheat Germ | GST | ||
Human | DUX4-2958H | Active Recombinant Human DUX4 Protein, GST-tagged | E.coli | GST | 263-424 aa | |
Human | DUX4-5857H | Recombinant Human DUX4 protein, His-tagged | E.coli | His | 327-424aa | |
Human | DUX4-4133HF | Recombinant Full Length Human DUX4 Protein, GST-tagged | In Vitro Cell Free System | GST | 424 amino acids |
- Q&As
- Reviews
Q&As (0)
Ask a questionAsk a Question for All DUX4 Products
Required fields are marked with *
My Review for All DUX4 Products
Required fields are marked with *