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DYNC1H1

  • Official Full Name

    dynein, cytoplasmic 1, heavy chain 1

  • Overview

    Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family.
  • Synonyms

    DYNC1H1; dynein, cytoplasmic 1, heavy chain 1; DNCH1, DNCL, DNECL, dynein, cytoplasmic, heavy polypeptide 1; cytoplasmic dynein 1 heavy chain 1; DHC1; Dnchc1; HL 3; p22; cytoplasmic dynein heavy chain 1; DHC1a; DKFZp686P2245; DNCH1; DNECL; DYHC; dynein heavy chain, cytosolic; dynein, cytoplasmic-like; HL-3; KIAA0325; dynein, cytoplasmic, heavy polypeptide 1; DNCL; CMT20;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DYNC1H1-2965H Recombinant Human DYNC1H1 Protein, GST-tagged Wheat Germ GST
Human DYNC1H1-519HCL Recombinant Human DYNC1H1 cell lysate N/A
Human DYNC1H1-1637H Recombinant Human DYNC1H1 protein, His & T7-tagged E.coli His/T7 Ala20~Leu285 (Accession # Q14204)
Human DYNC1H1-1975H Recombinant Human DYNC1H1 Protein (Ala20-Leu285), N-His tagged E.coli N-His Ala20-Leu285
Mouse DYNC1H1-4905M Recombinant Mouse DYNC1H1 Protein Mammalian Cell His
Mouse DYNC1H1-2579M-B Recombinant Mouse DYNC1H1 Protein Pre-coupled Magnetic Beads HEK293
Mouse DYNC1H1-2579M Recombinant Mouse DYNC1H1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DYNC1H1-1981R Recombinant Rat DYNC1H1 Protein Mammalian Cell His
Zebrafish DYNC1H1-3835Z Recombinant Zebrafish DYNC1H1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DYNC1H1 Related Articles

DYNC1H1 involved in several pathways and played different roles in them. We selected most pathways DYNC1H1 participated on our site, such as Adaptive Immune System, Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, which may be useful for your reference. Also, other proteins which involved in the same pathway with DYNC1H1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemLTN1;WWP1;GRAP2B;ERAP2;ASB11;TRIM11;AF251705;KIFAP3;IGKC
Anchoring of the basal body to the plasma membraneAKAP9;DCTN1A;NEK2;BBS13;TUBB4A;MAPRE1;TMEM67;IQCB1;CEP152
Assembly of the primary ciliumUNC119B;PCM1;HSPB11;NEDD1;CETN2;TUBB4A;FLR;NDE1;IFT27
Cell CyclePOT1;YWHAQ;E2F4;MCM3L;DCTN3;PCNA;ERCC6L;CLIP1;CDKN1B
Cell Cycle, MitoticTUBGCP3;RANGAP1B;NCAPG;SET;CCDC99;SDCCAG8;NEDD1;LIN52;H3F3B.1
Centrosome maturationCDK11A;TUBGCP3;DCTN2;HAUS2;FGFR1OP;CP110;MAPRE1;TUBGCP5;CEP76
G2/M TransitionSDCCAG8;DYNC1I2;CEP63;TUBGCP3;MYBL2;TCTN2;CEP70;TUBGCP4;MAPRE1
Immune SystemKIF2C;DEFA1;WWP1;KIF22;HECTD3;CTSB;RAPGEF3;SEC23A;PPIAL4A

DYNC1H1 has several biochemical functions, for example, ATP binding, ATPase activity, dynein light intermediate chain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DYNC1H1 itself. We selected most functions DYNC1H1 had, and list some proteins which have the same functions with DYNC1H1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingABCA6;PLK2B;SLK;SBK1;MAT2AL;AASDH;MATK;HSPA9;TTLL2
ATPase activityDYNC1H1;ABCA9;ABCG2C;PEX6;KIFC3;ABCB6;EIF4A2;MLH1;ABCA5
dynein light intermediate chain bindingDYNC1H1;DYNC2H1
microtubule motor activityKIF15;KIF2C;DNHD1;KIF23;KIF5B;DNAH11;DNAI2;SMC1A;KIF4A
poly(A) RNA bindingFDPS;NVL;PES1;MKI67IP;TFB1M;ARL6IP4;ZCCHC9;DUSP14;VCP
protein bindingWTAP;RND2;KIF1B;EXOC3;MORN4;ALOX12;CCDC120;RPS19BP1;POGK

DYNC1H1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DYNC1H1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DYNC1H1.

VCAM1; Cdk1; HTT; PSEN2; vpr; Ckap5; NFKB2; 7242199; TOR1A

Schneider, MA; Spoden, GA; et al. Identification of the dynein light chains required for human papillomavirus infection. CELLULAR MICROBIOLOGY 13:32-46(2011).
Huang, X; Wang, HL; et al. DYNLT3 Is Required for Chromosome Alignment During Mouse Oocyte Meiotic Maturation. REPRODUCTIVE SCIENCES 18:983-989(2011).
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