DYNLL1

Official Full Name

dynein, light chain, LC8-type 1

Background

Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.

Synonyms

dynein, light chain, LC8-type 1; 8 kDa dynein light chain; DLC1; DNCLC1; PIN; LC8a; DLC8; MGC126137; DNCL1; MGC126138; LC8; cytoplasmic dynein light polypeptide; dynein, cytoplasmic, light polypeptide 1; dynein light chain 1, cytoplasmic; hdlc1; Protein inhibitor of neuronal nitric oxide synthase; Dynein light chain LC8-type 1