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DYRK1A

  • Official Full Name

    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

  • Overview

    Minibrain (MNBH) is also known as DYRK1 and is the human homolog of the mnb gene in Drosophila and is mapped on human chromosome 21q22.2,Which is within the down syndrome critical region. MNBH may be involved in the signaling pathway that controls cell proliferation and is thought to regulate neuronal differentiation and apoptosis by phosphorylating Hip-1.
  • Synonyms

    DYRK1A; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; DYRK, DYRK1, MNBH; dual specificity tyrosine-phosphorylation-regulated kinase 1A; hMNB; MNB/DYRK protein kinase; serine/threonine kinase MNB; mnb protein kinase homolog hp86; protein kinase minibrain homolog; dual specificity YAK1-related kinase; serine/threonine-specific protein kinase; MNB; DYRK; HP86; MNBH; MRD7; DYRK1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • DDK
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DYRK1A-26456TH Recombinant Human DYRK1A Wheat Germ N/A 90 amino acids
Human DYRK1A-19H Recombinant Human DYRK1A, GST-tagged Insect Cell GST
Human DYRK1A-2981H Active Recombinant Human DYRK1A Protein, GST-tagged Insect Cell GST
Human DYRK1A-776H Recombinant Human DYRK1A Protein, DDK-tagged Sf9 Insect Cell DDK
Human DYRK1A-227H Recombinant Human DYRK1A, His-tagged E.coli His 159-479aa
Human DYRK1A-2982H Recombinant Human DYRK1A Protein, GST-tagged Wheat Germ GST
Human DYRK1A-6752HCL Recombinant Human DYRK1A 293 Cell Lysate HEK293 N/A
Human DYRK1A-1346HFL Recombinant Full Length Human DYRK1A Protein, C-DDK-tagged Mammalian cells DDK
Human DYRK1A-5H Recombinant Human DYRK1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DYRK1A-7655HF Active Recombinant Full Length Human DYRK1A Protein, GST-tagged Insect (sf21) GST 1-763
Human DYRK1A-0398H Recombinant Human DYRK1A Protein (S127-E485), Tag Free E.coli No tag S127-E485
Human DYRK1A-5H-B Recombinant Human DYRK1A Protein Pre-coupled Magnetic Beads HEK293
Human DYRK1A-0399H Recombinant Human DYRK1A Protein (S127-E485), His tagged E.coli His S127-E485
Rat DYRK1A-1990R Active Recombinant Rat Dyrk1a protein, GST-tagged E.coli GST
Rhesus Macaque DYRK1A-1363R Recombinant Rhesus monkey DYRK1A Protein, His-tagged Mammalian Cell His
Rhesus Macaque DYRK1A-1188R Recombinant Rhesus Macaque DYRK1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DYRK1A-1188R-B Recombinant Rhesus Macaque DYRK1A Protein Pre-coupled Magnetic Beads HEK293
Chicken DYRK1A-6119C Recombinant Chicken DYRK1A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DYRK1A Related Articles
  • DYRK1A Related Research Area
  • DYRK1A Related Signal Pathway

DYRK1A involved in several pathways and played different roles in them. We selected most pathways DYRK1A participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, G0 and Early G1, which may be useful for your reference. Also, other proteins which involved in the same pathway with DYRK1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell CycleMASTL;PDS5A;CHEK2;USO1;RAD50;MIS18A;KIF20A;ORC5;ANKLE2
Cell Cycle, MitoticNUP35;VRK1;CSNK2B;CLIP1;SPC24;MCM8;CTDNEP1A;CENPJ;CEP70
G0 and Early G1LIN52;LIN9;PIANP;DYRK1A;E2F4;LIN37;LIN54;TOP2A;MYBL2
Hedgehog Signaling PathwayGSK3B;WNT11;GLI3;FBXW11A;CSNK1G2A;WNT8B;SKI;WNT6;RAB23
Mitotic G1-G1/S phasesMYBL2;DYRK1A;LIN37;LIN52;LIN54;TOP2A;LIN9;MYCA

DYRK1A has several biochemical functions, for example, ATP binding, identical protein binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DYRK1A itself. We selected most functions DYRK1A had, and list some proteins which have the same functions with DYRK1A. You can find most of the proteins on our site.

Function Related Protein
ATP bindingITK;IQCA1;PSKH2;IP6K1;HSPA9;NEK4;MCM8;IARS;P2RX7
identical protein bindingDIAPH1;ZDHHC17;VWA2;ANXA4;BIRC5;UHRF1;TRAF6;DCTPP1;ZBTB16
non-membrane spanning protein tyrosine kinase activitySTYK1;TXK;BMX;CLK1;CSK;FYN;HCK;PTK2B;STK16
protein bindingATF7;ARHGAP17;BBS12;TFDP2;TCF7L1A;TMED2;ZFYVE21;BBS9;SCN5A
protein kinase activityINSRB;PKDCC;LIMK1;PTK2;NEK4;PKDCCA;MAP2K2A;GSG2;BMPR2A
protein self-associationVAMP2;EPB49;CTSC;CNTN2;TP53;PABPN1;TMEM43;CCL5;SLC9A3R1
protein serine/threonine kinase activityNUAK1;SLKA;NLK;MAPK12B;RPS6KB1B;EIF2AK2;PRKDC;CDC42BPB;PDK3
protein serine/threonine/tyrosine kinase activityMAP2K1;DYRK4;DYRK3;DYRK2;DSTYK;TNK2;MAP2K2;PRKCG;AURKC
protein tyrosine kinase activityZNF143B;MATK;HCK;IGF1RB;FGFR4;WEE1;ROS1;PDGFRB;TYK2
tau protein bindingAPOE;SNCA;PPP2R2A;HDAC6;DYRK1A;FKBP4;SERPINB1A;AATF;BIN1

DYRK1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DYRK1A here. Most of them are supplied by our site. Hope this information will be useful for your research of DYRK1A.

DCAF7; YWHAG; RB1; RBL1; TROAP; LZTS2; YWHAE

Kida, E; Walus, M; et al. FORM OF DUAL-SPECIFICITY TYROSINE-(Y)-PHOSPHORYLATION-REGULATED KINASE 1A NONPHOSPHORYLATED AT TYROSINE 145 AND 147 IS ENRICHED IN THE NUCLEI OF ASTROGLIAL CELLS, ADULT HIPPOCAMPAL PROGENITORS, AND SOME CHOLINERGIC AXON TERMINALS. NEUROSCIENCE 195:112-127(2011).
Lilienthal, E; Kolanowski, K; et al. Development of a sensitive non-radioactive protein kinase assay and its application for detecting DYRK activity in Xenopus laevis oocytes. BMC BIOCHEMISTRY 11:-(2010).
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