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DYRK2

  • Official Full Name

    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

  • Overview

    DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or;development. The family is defined by structural similarity of their kinase domains and their capability to;autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed;phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform,;isoform 1, lacks a 5 terminal insert.
  • Synonyms

    DYRK2; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; dual specificity tyrosine-phosphorylation-regulated kinase 2; FLJ21217; FLJ21365;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DYRK2-1397H Active Recombinant Human DYRK2, GST-tagged E.coli GST
Human DYRK2-2986H Active Recombinant Human DYRK2 Protein, GST-tagged Insect Cell GST
Human DYRK2-518H Recombinant Human DYRK2, His-tagged Sf9 Insect Cell His
Human DYRK2-2987H Recombinant Human DYRK2 Protein, GST-tagged Wheat Germ GST
Human DYRK2-6750HCL Recombinant Human DYRK2 293 Cell Lysate HEK293 N/A
Human DYRK2-3077HF Active Recombinant Full Length Human DYRK2 Protein, GST-tagged Insect (sf21) GST 1-528
Human DYRK2-4077HF Recombinant Full Length Human DYRK2 Protein, GST-tagged In Vitro Cell Free System GST 528 amino acids
Human DYRK2-2334H Recombinant Human DYRK2 protein, His-tagged Insect Cell His 1-528aa
Human DYRK2-1125H Recombinant Human DYRK2 Protein (L2-S601), GST tagged E.coli GST L2-S601
Human DYRK2-1124H Recombinant Human DYRK2 Protein (L2-S601), Tag Free E.coli No tag L2-S601
Mouse DYRK2-4923M Recombinant Mouse DYRK2 Protein Mammalian Cell His
Mouse DYRK2-2592M Recombinant Mouse DYRK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DYRK2-2592M-B Recombinant Mouse DYRK2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DYRK2-1365R Recombinant Rhesus monkey DYRK2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DYRK2-1190R-B Recombinant Rhesus Macaque DYRK2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DYRK2-1190R Recombinant Rhesus Macaque DYRK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish DYRK2-3962Z Recombinant Zebrafish DYRK2 Mammalian Cell His
Chicken DYRK2-3127C Recombinant Chicken DYRK2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DYRK2 Related Research Area

DYRK2 involved in several pathways and played different roles in them. We selected most pathways DYRK2 participated on our site, such as p53 pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DYRK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
p53 pathwayTTC5;TRIM28;CSNK1G3;NEDD8;PPP1R13L;SMYD2;DYRK2;E4F1;RASSF1

DYRK2 has several biochemical functions, for example, ATP binding, magnesium ion binding, manganese ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DYRK2 itself. We selected most functions DYRK2 had, and list some proteins which have the same functions with DYRK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingATP2B3A;KIF3B;RENBP;SLC27A2;TTLL12;HIPK3;UBE2R2;MAPK8B;KIF15
magnesium ion bindingFEN1;PPM1A;ATP10A;WRN;MAPK12;INPP1;HPRT1L;LATS1;STK36
manganese ion bindingNUDT7;GALNT2;ABL2;NUDT16;MTPAP;MRE11A;HMGCL;GALNT1;PPM1M
protein bindingKLF13;KIAA0101;CRX;FBXW5;CDH1;EEF1A2;MORN4;AURKB;SLC35F6
protein serine/threonine kinase activityGSK3A;TESK2;ROCK2B;SBK3;CDKL5;DSTYK;MAPK12B;TTBK2;BMPR2B
protein serine/threonine/tyrosine kinase activityAURKB;MAP2K1;PRKAA2;TESK1;TESK2;DYRK4;AURKC;CLK1;DYRK1AA
protein tyrosine kinase activityAXL;ABL2;LCK;RET;PTK2B;FER;JAK2;EGFRA;ERBB4A
ubiquitin bindingSHRPRBCK1R;D17WSU92E;OTUB1;RNF168;USP5;VPS28;OTUB1A;PARK2;IWS1

DYRK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DYRK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DYRK2.

DYRK4; WDR62; SP100; IKZF1; ZBTB9; KXD1; LZTS2

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