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DYRK3

  • Official Full Name

    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3

  • Overview

    This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms

    DYRK3; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3; dual specificity tyrosine-phosphorylation-regulated kinase 3; dual specificity tyrosine (Y) phosphorylation regulated kinase 5; hYAK3 2; protein kinase Dyrk3; RED; REDK; regulatory e;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Rat
  • HEK293
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DYRK3-972H Active Recombinant Human DYRK3 protein(Met1-Ser588), His&GST-tagged Insect Cells N-His&GST Met1-Ser588
Human DYRK3-2989H Active Recombinant Human DYRK3 Protein, GST-tagged Insect Cell GST
Human DYRK3-2990H Recombinant Human DYRK3 Protein, GST-tagged Wheat Germ GST
Human DYRK3-623HCL Recombinant Human DYRK3 cell lysate Insect Cell N/A
Human DYRK3-5436HF Active Recombinant Full Length Human DYRK3 Protein, GST-tagged Insect (sf21) GST 1-588
Human DYRK3-0400H Recombinant Human DYRK3 Protein (G2-S588), Tag Free Insect Cell No tag G2-S588
Human DYRK3-0401H Recombinant Human DYRK3 Protein (G2-S588), GST tagged Insect Cell GST G2-S588
Human DYRK3-4092HF Recombinant Full Length Human DYRK3 Protein, GST-tagged In Vitro Cell Free System GST 568 amino acids
Rat DYRK3-1991R Recombinant Rat DYRK3 Protein Mammalian Cell His
Rat DYRK3-1648R Recombinant Rat DYRK3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DYRK3-1648R-B Recombinant Rat DYRK3 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey DYRK3-474C Recombinant Cynomolgus DYRK3 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey DYRK3-220C-B Recombinant Cynomolgus Monkey DYRK3 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey DYRK3-220C Recombinant Cynomolgus Monkey DYRK3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DYRK3 Related Articles
  • DYRK3 Related Research Area

DYRK3 involved in several pathways and played different roles in them. We selected most pathways DYRK3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DYRK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

DYRK3 has several biochemical functions, for example, ATP binding, magnesium ion binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DYRK3 itself. We selected most functions DYRK3 had, and list some proteins which have the same functions with DYRK3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCCT5;KIF18A;HSPA8;HSPA5;ACVR1B;DDX25;KIF14;MAP3K13;STK25A
magnesium ion bindingERN1;PPA2;WEE1;NT5C1AA;PI4K2A;WEE2;TESC;NUDT18;HPGDS
protein kinase activityBMPR2A;MAPKAPK2A;PRKAG1;STK35L;DAPK1;RIPK3;MAP2K5;MMD2;SGK2A
protein serine/threonine kinase activityPRKACAB;IRAK4;PLK3;MARK4;RIOK3;MYLK4;CHEK1;DCLK3;ROCK2B
protein serine/threonine/tyrosine kinase activityRPS6KA2;TESK2;DYRK3;DYRK1AA;MAP2K2;PRKACA;TNK2;PRKAA2;DYRK1B
protein tyrosine kinase activityTNK2B;FES;KIT;FGFR2;SRC;EPHB4A;ABL1;CAMKK2;CLK2

DYRK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DYRK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DYRK3.

saicar; PRNP; PKM; SORL1; SIRT1

Souchet, B; Latour, A; et al. Molecular Rescue of DYRK1A Overexpression in Cystathionine Beta Synthase-Deficient Mouse Brain by Enriched Environment Combined with Voluntary Exercise. JOURNAL OF MOLECULAR NEUROSCIENCE 55:318-323(2015).
Mennenga, SE; Gerson, JE; et al. Harmine treatment enhances short-term memory in old rats: Dissociation of cognition and the ability to perform the procedural requirements of maze testing. PHYSIOLOGY & BEHAVIOR 138:260-265(2015).
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