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Dact1

  • Official Full Name

    dishevelled-binding antagonist of beta-catenin 1

  • Overview

    The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
  • Synonyms

    DACT1; dishevelled-binding antagonist of beta-catenin 1; DPR1; FRODO; HDPR1; DAPPER; THYEX3; DAPPER1; dapper homolog 1; dapper antagonist of catenin 1; heptacellular carcinoma novel gene 3; dapper, antagonist of beta-catenin, homolog 1; hepatocellular carcinoma novel gene 3 protein;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DACT1-2322H Recombinant Human DACT1 Protein, GST-tagged Wheat Germ GST
Human DACT1-7084HCL Recombinant Human DACT1 293 Cell Lysate HEK293 N/A
Zebrafish DACT1-12757Z Recombinant Zebrafish DACT1 Mammalian Cell His
Chicken DACT1-3483C Recombinant Chicken DACT1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Dact1 Related Articles

Dact1 involved in several pathways and played different roles in them. We selected most pathways Dact1 participated on our site, such as Degradation of DVL, Signal Transduction, Signaling by Wnt, which may be useful for your reference. Also, other proteins which involved in the same pathway with Dact1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Degradation of DVLDVL2;HECW1B;DVL3;DACT1;HECW1;DVL1;KLHL12
Signal TransductionCDC42EP1B;DEPDC1B;CNR2;GPR18;TAAR1;ARHGAP24;PRC1;OR2AP1;OPN4B
Signaling by WntRSPO3;RNF146;CBY1;RSPO1;SOX7;SOX4A;HECW1;RYK;PYGO2
TCF dependent signaling in response to WNTSOX4B;WIF1;DACT1;RYK;LGR6;RSPO4;USP34;BCL9L;PYGO2

Dact1 has several biochemical functions, for example, beta-catenin binding, delta-catenin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Dact1 itself. We selected most functions Dact1 had, and list some proteins which have the same functions with Dact1. You can find most of the proteins on our site.

Function Related Protein
beta-catenin bindingSALL1;MED12;SLC9A3R1;CBY1;BCL9L;EP300;PXN;PTPRU;DACT3
delta-catenin bindingCDH24;PLEKHA7;DACT1;DACT2;PLEKHA7A;PTPRJ;DACT3
protein bindingSMCO4;TRIM38;DNAL4;CNTNAP2;CCDC22;TTC3;PDPK1;KIR2DL1;LRRC3
protein kinase A bindingRPS3;DACT3;MYRIP;AKAP5;AKAP12;DACT2;NBEA;LRRK2;Akap2
protein kinase C bindingTDG;DACT1;PARD3;PLEK;NELL2;SDPRB;DACT3;HINT1;HDAC9

Dact1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Dact1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Dact1.

DVL2; YWHAB; CTNNB1; GSK3B; AXIN1; Prkaca; YWHAQ; SFN

Gan, TQ; Tang, RX; et al. Upregulated MiR-1269 in hepatocellular carcinoma and its clinical significance. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 8:714-721(2015).
Schussel, JL; Kalinke, LP; et al. Expression and epigenetic regulation of DACT1 and DACT2 in oral squamous cell carcinoma. CANCER BIOMARKERS 15:11-17(2015).
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