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Ddn

  • Official Full Name

    dendrin

  • Overview

    Dendrin is a neural and renal protein whose exact function is still relatively unclear; however, its location in the brain and kidneys is well known as are some of the neural processes it affects. Within the brain, dendrin can be found in neurons and is most notably associated with sleep deprivation. Sleep deprivation causes some areas of the brain dendrin levels to increase, but this increase is insignificant and in total sleep deprivation causes a decrease of the mRNA and protein form of dendrin. Along with two other proteins, MAGI/S-SCAM and α-actinin, dendrin is linked to synaptic plasticity and memory formation in the brain. Nicotine levels have also been shown to have an effect on dendrin expression in the brain. Although unlike sleep deprivation, nicotine increases overall dendrin level. Originally thought to be a brain specific protein, there is now evidence to suggest that dendrin is also found in the kidneys. Dendrin is used to detect glomerulopathy or renal disease, based on its location in the kidneys. Within the kidneys it also works to prevent urinary protein loss. Most studies and information on dendrin pertain specifically to rat or mice brains.
  • Synonyms

    Gm748; DDN; dendrin;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DDN-3716H Recombinant Human DDN protein, His-tagged E.coli His 484-711 aa
Mouse DDN-4390M Recombinant Mouse DDN Protein Mammalian Cell His
Mouse DDN-2256M Recombinant Mouse DDN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DDN-2256M-B Recombinant Mouse DDN Protein Pre-coupled Magnetic Beads HEK293
Rat DDN-1813R Recombinant Rat DDN Protein Mammalian Cell His
Rat DDN-1471R-B Recombinant Rat DDN Protein Pre-coupled Magnetic Beads HEK293
Rat DDN-1471R Recombinant Rat DDN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

Ddn involved in several pathways and played different roles in them. We selected most pathways Ddn participated on our site, such as PodNet: protein-protein interactions in the podocyte, XPodNet - protein-protein interactions in the podocyte expanded by STRING, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ddn were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PodNet: protein-protein interactions in the podocyteLIMS2;FAM65A;TENC1;CMIP;DDN;SDK1;FRAS1
XPodNet - protein-protein interactions in the podocyte expanded by STRINGWLS;ARHGAP32;MICALL2;FRAS1;SNTB1;LIMS2;DDN;CMIP;ZFP423

Ddn has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ddn itself. We selected most functions Ddn had, and list some proteins which have the same functions with Ddn. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingEN1;SALL1;ZNF502;EBF2;RBPJL;IRF1;ZNF562;CEBPA;CARF
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific bindingFOSL2;HIST2H3A;IRF7;FOSB;SNAI3;CLOCK;SFPI1;JDP2;BATF

Ddn has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ddn here. Most of them are supplied by our site. Hope this information will be useful for your research of Ddn.

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