Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

Ddr2

  • Official Full Name

    discoidin domain receptor tyrosine kinase 2

  • Overview

    Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5 UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
  • Synonyms

    DDR2; discoidin domain receptor tyrosine kinase 2; TKT; MIG20a; NTRKR3; TYRO10; discoidin domain-containing receptor 2; tyrosylprotein kinase; hydroxyaryl-protein kinase; discoidin domain receptor 2; tyrosine-protein kinase TYRO10; CD167 antigen-like family member B; cell migration-inducing protein 20; migration-inducing gene 16 protein; receptor protein-tyrosine kinase TKT; discoidin domain receptor family, member 2; neurotrophic tyrosine kinase receptor related 3; neurotrophic tyrosine kinase, receptor-related 3; discoidin domain-containing receptor tyrosine kinase 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus
  • Rhesus macaque
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • hFc
  • His
  • Myc
  • DDK
  • DDK|His
  • Fc
  • Fc|His
  • Flag
  • GST
  • GST|His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • Myc|DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DDR2-820H Active Recombinant Human DDR2, GST-tagged Sf9 Insect Cell GST 467-end
Human DDR2-28310TH Recombinant Human DDR2 Protein (22-399aa), C-His tagged Insect Cell C-His 22-399aa
Human DDR2-294H Recombinant Human DDR2, GST-tagged, Active Sf9 Insect Cell GST
Human DDR2-136H Recombinant Human DDR2, Fc tagged Human Cell Fc
Human DDR2-759H Recombinant Human DDR2 Protein, DDK/His-tagged HEK293 DDK/His
Human DDR2-40H Recombinant Human DDR2 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human DDR2-7277H Recombinant Human DDR2, His & GST tagged Insect Cell His/GST
Human DDR2-760H Recombinant Human DDR2 Protein, DDK-tagged Sf9 Insect Cell DDK
Human DDR2-5685H Recombinant Human DDR2 protein, His & T7-tagged E.coli His/T7 His578~Pro817 (Accession # Q16832)
Human DDR2-352H Recombinant Human DDR2, His tagged Human Cell Fc/His
Human DDR2-205H Recombinant Human DDR2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DDR2-137H Recombinant Human DDR2, None tagged Human Cell N/A
Human DDR2-2456H Active Recombinant Human DDR2 Protein, GST-His-tagged Insect Cell GST/His
Human DDR2-2457H Recombinant Human DDR2 Protein, GST-tagged Wheat Germ GST
Human DDR2-001HCL Recombinant Human DDR2 cell lysate Insect Cell N/A
Human DDR2-1033HCL Recombinant Human DDR2 cell lysate Human Cell N/A
Human DDR2-2049H Recombinant Human DDR2 Protein, His-tagged HEK293 His Gln24-Arg399
Human DDR2-382H Recombinant Human DDR2 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human DDR2-2503HF Recombinant Full Length Human DDR2 Protein, GST-tagged In Vitro Cell Free System GST 855 amino acids
Human DDR2-5383H Recombinant Human DDR2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DDR2-107H Recombinant Human DDR2 Protein, C-His-tagged E.coli C-His
Human DDR2-1310H Recombinant Human DDR2 Protein (R422-E855), GST tagged Insect Cell GST R422-E855
Human DDR2-1465HFL Recombinant Full Length Human DDR2 Protein, C-Flag-tagged Mammalian cells Flag
Human DDR2-3009H Recombinant Human DDR2 protein, His-tagged E.coli His 291-398 aa
Human DDR2-736H Recombinant Human DDR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DDR2-1309H Recombinant Human DDR2 Protein (R422-E855), Tag Free Insect Cell No tag R422-E855
Human DDR2-4745H Recombinant Human DDR2 Protein (Met1-Arg399), C-His tagged Mammalian cells C-His Met1-Arg399
Human DDR2-2646H Active Recombinant Human DDR2 protein, His-tagged HEK293 His Gln24-Arg399
Human DDR2-736H-B Recombinant Human DDR2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ddr2-745M Active Recombinant Mouse Ddr2 Protein, Fc Chimera Mammalian cells Fc
Mouse Ddr2-773M Recombinant Mouse Ddr2, His tagged Human Cell His
Mouse DDR2-2172MCL Recombinant Mouse DDR2 cell lysate Human Cell N/A
Mouse Ddr2-5721M Recombinant Mouse Ddr2 Protein (Gln24-Arg399), C-His tagged Mammalian cells C-His Gln24-Arg399
Mouse Ddr2-2496M Recombinant Mouse Ddr2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Ddr2-24M Recombinant Mouse Ddr2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ddr2-24M-B Recombinant Mouse Ddr2 Protein Pre-coupled Magnetic Beads HEK293
Rat Ddr2-8783R Recombinant Rat Ddr2 protein(Met1-Arg399), His-tagged HEK293 C-His Met1-Arg399
Rat Ddr2-8782R Active Recombinant Rat Ddr2 protein(Met1-Arg399), hFc-tagged HEK293 C-hFc Met1-Arg399
Rat DDR2-1296RCL Recombinant Rat DDR2 cell lysate Human Cell N/A
Cynomolgus DDR2-119C Recombinant Cynomolgus DDR2 Protein, His-tagged HEK293 His
Cynomolgus Monkey DDR2-120C Recombinant Cynomolgus DDR2, His tagged Human Cell His
Cynomolgus Monkey DDR2-1017CCL Recombinant Cynomolgus DDR2 cell lysate Human Cell N/A
Rhesus DDR2-121R Active Recombinant Rhesus DDR2 protein(Met1-Arg399), hFc-tagged HEK293 C-hFc Met1-Arg399
Rhesus DDR2-122R Recombinant Rhesus DDR2 protein, His-tagged HEK293 His Met1-Arg399
Rhesus macaque DDR2-192R Recombinant Rhesus macaque DDR2 Protein, His-tagged HEK293 His 855
Rhesus macaque DDR2-193R Recombinant Rhesus macaque DDR2 Protein, Fc-tagged HEK293 Fc 855
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Ddr2 Related Articles
  • Ddr2 Related Research Area

Ddr2 involved in several pathways and played different roles in them. We selected most pathways Ddr2 participated on our site, such as Endochondral Ossification, Extracellular matrix organization, Non-integrin membrane-ECM interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ddr2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Endochondral OssificationFRZB;SOX6;SOX9A;COL10A1;PTHLH;CST5;PTH;CTSL2;CDKN1C
Extracellular matrix organizationPCOLCEB;ABHD1;TLL2;LOX;FBLN2;MMP20;DMP1;MFAP2;COL10A1
Non-integrin membrane-ECM interactionsTRAPPC4;DDR1;DDR2;TTR;LAMC3;DMD

Ddr2 has several biochemical functions, for example, ATP binding, collagen binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ddr2 itself. We selected most functions Ddr2 had, and list some proteins which have the same functions with Ddr2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPRKD1;SKIV2L;PRKACAB;MAP2K7;SGK3;OXSR1A;PCXA;CARNS1;MAP3K12
collagen bindingSMAD4;CTSK;GP6;NID2;C1QTNF1;ITGA1;PDGFB;PAK1;ITGA3
protein bindingMYO10;E2F7;USP4;SPC24;JDP2;TMEM74;ATP6AP2;OSBPL1A;DDI1
protein tyrosine kinase collagen receptor activityDDR1;DDR2
transmembrane receptor protein tyrosine kinase activityROS1;FLT4;INSRB;EPHB2B;TRIM27;ALK;FGFR1A;RYK;PDGFRA

Ddr2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ddr2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ddr2.

COL11A2; HSP90AB1; SHC1; imatinib; N/A; SRC; CBLB; CDC37; CHORDC1; GOLT1B

Thunnissen, E; van der Oord, K; et al. Prognostic and predictive biomarkers in lung cancer. A review. VIRCHOWS ARCHIV 464:347-358(2014).
Carafoli, F; Hohenester, E; et al. Collagen recognition and transmembrane signalling by discoidin domain receptors. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1834:2187-2194(2013).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All Ddr2 Products

Required fields are marked with *

My Review for All Ddr2 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends