Dhfr
-
Official Full Name
dihydrofolate reductase
-
Overview
Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014] -
Synonyms
DHFR; dihydrofolate reductase; DYR; DHFRP1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Chicken
- Hamster
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- Dhfr Related Articles
Dhfr involved in several pathways and played different roles in them. We selected most pathways Dhfr participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, E2F mediated regulation of DNA replication, which may be useful for your reference. Also, other proteins which involved in the same pathway with Dhfr were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Cell Cycle | E2F3;CENPH;ESCO2;HIST4H4;CCNE2;MCM9;SETA;FZR1;ARPP19B |
Cell Cycle, Mitotic | SKA2;DNA2;KIF2C;NIPBL;CEP135;POLD3;TUBGCP4;TUBG2;CDK4 |
E2F mediated regulation of DNA replication | |
E2F transcription factor network | YY1;CES5A;HIC1;UXT;CDKN2C;CES3;CES1;E2F4;MYBL2 |
Fluoropyrimidine Activity | SLC22A7;DHFR;CES1;DPYS;UPP2;DPYD;TYMP |
Folate biosynthesis | GGH;QDPRB1;ALPPL2;QDPRA;QDPRB2;SPR;MOCS2;ALPP;ALP3 |
G1/S Transition | CKS1B;DHFR;MYCA |
G1/S-Specific Transcription |
Dhfr has several biochemical functions, for example, NADPH binding, dihydrofolate reductase activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Dhfr itself. We selected most functions Dhfr had, and list some proteins which have the same functions with Dhfr. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
NADPH binding | TP53I3;GRHPR;FASN;CBR4;MTRR;KCNAB1;DHFR;HMGCR;QDPR |
dihydrofolate reductase activity | DHFRL1;DHFR |
drug binding | ABP1;PYGM;GSTP2;CYP4B1;IL2RA;ADH1;GRIK1;SRP54B;P2RX4 |
folic acid binding | TYMS;FOLR3;DHFR;DAAM2;FTCD;FOLR1;SLC46A1;MTHFS;FOLR2 |
mRNA binding | SSB;RBMX;KHSRP;NUDT16;ZFP36L1;DOM3Z;MECP2;DXO;TPR |
methotrexate binding | DHFR;FOLR1;DAAM2;FOLR2 |
Dhfr has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Dhfr here. Most of them are supplied by our site. Hope this information will be useful for your research of Dhfr.
nleF
- Q&As
- Reviews
Q&As (5)
Ask a questionMethotrexate is a common DHFR inhibitor drug used in cancer treatment.
Yes, scientists continue to research and develop new DHFR inhibitors with improved efficacy and reduced side effects for various clinical applications.
Yes, drug-resistant strains have emerged due to mutations in DHFR genes, reducing the effectiveness of DHFR inhibitor drugs.
Yes, common side effects of DHFR inhibitors include nausea, vomiting, decreased blood cell counts, and liver toxicity.
Trimethoprim is an antibiotic that inhibits DHFR in bacteria.
Customer Reviews (3)
Write a reviewThe DHFR protein offered by the manufacturer is of exceptional quality, making it an ideal choice to fulfill my experimental needs.
Another crucial aspect where the manufacturer excels is their efficient supply chain management.
The technical support provided by the manufacturer is invaluable in overcoming experimental hurdles and optimizing the utilization of DHFR protein.
Ask a Question for All Dhfr Products
Required fields are marked with *
My Review for All Dhfr Products
Required fields are marked with *