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DLAT

  • Official Full Name

    dihydrolipoamide S-acetyltransferase

  • Overview

    This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.[provided by RefSeq, Oct 2009]
  • Synonyms

    DLAT; dihydrolipoamide S-acetyltransferase; DLTA; PDCE2; PDC-E2; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; PBC; M2 antigen complex 70 kDa subunit; pyruvate dehydrogenase complex component E2; E2 component of pyruvate dehydrogenase complex; 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cells
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DLAT-45H Recombinant Human DLAT protein, His-tagged E.coli His Gln374~Trp631
Human DLAT-2670H Recombinant Human DLAT Protein, GST-tagged Wheat Germ GST
Human DLAT-6914HCL Recombinant Human DLAT 293 Cell Lysate HEK293 N/A
Human DLAT-1966H Recombinant Human DLAT Protein (Gln374-Trp631), His tagged E.coli His Gln374-Trp631
Human DLAT-1279H Recombinant Human DLAT protein, His-tagged Insect Cells His Ser87-Leu647
Human DLAT-3974HF Recombinant Full Length Human DLAT Protein, GST-tagged In Vitro Cell Free System GST 647 amino acids
Human DLAT-456H Recombinant Human DLAT Protein (93-640 aa), His-tagged E.coli His 93-640 aa
Human DLAT-30191H Recombinant Human DLAT protein, GST-tagged E.coli GST Met1-Thr322
Mouse DLAT-4614M Recombinant Mouse Dlat protein, His-tagged HEK293 His 86-642aa
Mouse Dlat-46M Recombinant Mouse Dlat protein, His-tagged E.coli His Thr368~Trp626
Mouse Dlat-2573M Recombinant Mouse Dlat Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Dlat-4608M Recombinant Mouse Dlat protein, His-tagged E.coli His 86-642aa
Mouse DLAT-2218M Recombinant Mouse DLAT Protein (86-642 aa), His-tagged Yeast His 86-642 aa
Rat DLAT-1876R Recombinant Rat DLAT Protein Mammalian Cell His
Rat DLAT-1535R Recombinant Rat DLAT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DLAT-1535R-B Recombinant Rat DLAT Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DLAT-1275R Recombinant Rhesus monkey DLAT Protein, His-tagged Mammalian Cell His
Rhesus Macaque DLAT-1100R-B Recombinant Rhesus Macaque DLAT Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DLAT-1100R Recombinant Rhesus Macaque DLAT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish DLAT-11943Z Recombinant Zebrafish DLAT Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DLAT Related Articles

DLAT involved in several pathways and played different roles in them. We selected most pathways DLAT participated on our site, such as Biosynthesis of antibiotics, Carbon metabolism, Citrate cycle (TCA cycle), which may be useful for your reference. Also, other proteins which involved in the same pathway with DLAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Biosynthesis of antibioticsACAA2;DLD;AMDHD2;UAP1L1;DAO;PAICS;ECHS1;AGXT;BPNT1
Carbon metabolismpykF;MDH1;RPE;ackA;ACSS2L;ACSS1;ACAT2;PKM2;SDHDB
Citrate cycle (TCA cycle)MDH2;DLD;DLDH;PCK2;PDHA1B;DLST;SDHD;OGDH;IDH3B
Glycolysis / GluconeogenesisACSS1;GPIB;G6PC;PGAM2;PFKMB;PGAM1A;GAPDH;PGAM1B;TPI1
Glycolysis and GluconeogenesisLDHAL6B;MPC2;DLAT;SLC2A3;MPC1;BRP44
Metabolic pathwaysHSD17B7;CYP2C50;AGXTB;TH;CYP2B19;ADH7;MTM1;GPIA;DAD1
MetabolismUGT1B4;PCBD1;GC;ALOX5B.2;Sult2a2;CYP3A7;SLC6A12;PPP1R2;SACM1L
Pyruvate metabolismFH1;PKM2;ALDH9A1A.1;PDK3B;ACYP1;PKMB;ALDH3A2;PKM;ACYP2

DLAT has several biochemical functions, for example, dihydrolipoyllysine-residue acetyltransferase activity, protein binding, contributes_to pyruvate dehydrogenase (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DLAT itself. We selected most functions DLAT had, and list some proteins which have the same functions with DLAT. You can find most of the proteins on our site.

Function Related Protein
dihydrolipoyllysine-residue acetyltransferase activity
protein bindingUHRF1;TRPV5;CNBP;TERF1;FAM81B;RPRM;SUV39H1;IL15;FCNA
contributes_to pyruvate dehydrogenase (NAD+) activityPDHX;PDHB;DLD;DLAT

DLAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DLAT here. Most of them are supplied by our site. Hope this information will be useful for your research of DLAT.

SIRT4; PDHB; SIRT3; PDHX; PRKD3; q9wmx2-pro_0000037548; midostaurin; ANXA1

Tian, J; Bryk, R; et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. MOLECULAR MICROBIOLOGY 57:859-868(2005).
  • Q&As
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