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Dock8

  • Official Full Name

    dedicator of cytokinesis 8

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Yeast
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DOCK8-12H Recombinant Human DOCK8 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DOCK8-3734H Recombinant Human DOCK8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DOCK8-2255H Recombinant Human DOCK8 Protein (560-729 aa), His-tagged Yeast His 560-729 aa
Mouse DOCK8-4758M Recombinant Mouse DOCK8 Protein Mammalian Cell His
Mouse DOCK8-2251M Recombinant Mouse DOCK8 Protein (561-730 aa), His-tagged Yeast His 561-730 aa
Mouse Dock8-2628M Recombinant Mouse Dock8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DOCK8-2481M Recombinant Mouse DOCK8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DOCK8-2418M Recombinant Mouse DOCK8 Protein (561-730 aa), His-tagged E.coli His 561-730 aa
Mouse DOCK8-2481M-B Recombinant Mouse DOCK8 Protein Pre-coupled Magnetic Beads HEK293
Mouse Dock8-4614M Recombinant Mouse Dock8 protein, His-tagged E.coli His 1633-2067aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Dock8 Related Articles

Dock8 involved in several pathways and played different roles in them. We selected most pathways Dock8 participated on our site, such as Factors involved in megakaryocyte development and platelet production, Hemostasis, cyclic AMP biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Dock8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Factors involved in megakaryocyte development and platelet productionD-AKAP2;IRF2;KIF2A;AKAP1;HBB-BH1;AKAP1B;HBBE1.1;MFN2;KIF3C
HemostasisMMRN2A;SLC7A10;ZFPM2A;AKAP10;PHF21A;S100A10B;CFD;AASS;KIF11
cyclic AMP biosynthesisPDC;DOCK8;RALGAPA1;RAP1GAP2;ARHGAP33;GARNL3;RIC8

Dock8 has several biochemical functions, for example, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Dock8 itself. We selected most functions Dock8 had, and list some proteins which have the same functions with Dock8. You can find most of the proteins on our site.

Function Related Protein
guanyl-nucleotide exchange factor activityRASGRP1;DENND6A;CHRM4;TRIO;RALGPS1;RAPGEF3;GDPGP1;DENND1C;RAPGEF4

Dock8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Dock8 here. Most of them are supplied by our site. Hope this information will be useful for your research of Dock8.

Burbage, M; Keppler, SJ; et al. Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity. JOURNAL OF EXPERIMENTAL MEDICINE 212:53-72(2015).
Janssen, E; Morbach, H; et al. Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 134:1365-1374(2014).
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