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E2F5

  • Official Full Name

    E2F transcription factor 5, p130-binding

  • Overview

    The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms.
  • Synonyms

    E2F5; E2F transcription factor 5, p130-binding; transcription factor E2F5; E2F 5; E2F transcription factor 5; E2F transcription factor 5 p130 binding; p130 binding; OTTHUMP00000227505; OTTHUMP00000227506; OTTHUMP00000227507; OTTHUMP00000227508; E2F-5;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human E2F5-007H Recombinant Human E2F5 Protein, His-tagged E.coli His
Human E2F5-3009H Recombinant Human E2F5 Protein, GST-tagged Wheat Germ GST
Human E2F5-935H Recombinant Human E2F5 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human E2F5-4114HF Recombinant Full Length Human E2F5 Protein, GST-tagged In Vitro Cell Free System GST 346 amino acids
Mouse E2F5-4934M Recombinant Mouse E2F5 Protein Mammalian Cell His
Mouse E2F5-2598M Recombinant Mouse E2F5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse E2f5-2708M Recombinant Mouse E2f5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse E2F5-2598M-B Recombinant Mouse E2F5 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish E2F5-7826Z Recombinant Zebrafish E2F5 Mammalian Cell His
Zebrafish E2F5-11651Z Recombinant Zebrafish E2F5 Mammalian Cell His
Chicken E2F5-2631C Recombinant Chicken E2F5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

E2F5 involved in several pathways and played different roles in them. We selected most pathways E2F5 participated on our site, such as Cell cycle, TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with E2F5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell cycleCSNK2A1;BORA;MCM2;MCM3L;TFDP2;CCP110;TMEM188;ENSA;H3F3B.1
TGF-beta signaling pathwayGDF7;BMPR1BB;BMP8A;SMURF1;ID3;INHBE;INHBC;ID2B;GDF6A

E2F5 has several biochemical functions, for example, DNA binding, protein binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by E2F5 itself. We selected most functions E2F5 had, and list some proteins which have the same functions with E2F5. You can find most of the proteins on our site.

Function Related Protein
DNA bindingRIMKLB;ZNF71;MCM2;HIST1H4L;MTERFD1;ZBTB2;CASZ1;EP300;HLX1
protein bindingGATA1;PPP1R12C;CNEP1R1;PI4KA;PRKCD;FAM164A;CTSC;ARID3A;DYNAP
sequence-specific DNA bindingFOXC2;ZNF232;FOXD4;FOXP4;PBX2;RHOXF2;ESR2B;CUX2;SALL3
transcription factor activity, sequence-specific DNA bindingHOXB8A;TP63;FOXP4;ETV5B;FOXP3A;CSRNP1;SPI1A;BACH1;NEUROD1
transcription factor bindingTWIST1;ESR1;NR0B1;ZFPM2;JUN;CD34;TBL1X;FOXO4;NKX2-1

E2F5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with E2F5 here. Most of them are supplied by our site. Hope this information will be useful for your research of E2F5.

Tfdp2; Arid1a; Arid1b

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