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E2F6

  • Official Full Name

    E2F transcription factor 6

  • Overview

    This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms.
  • Synonyms

    E2F6; E2F transcription factor 6; transcription factor E2F6; E2F 6; E2F transcription factor 6, isoform 1; E2F-6; MGC111545;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human E2F6-26508TH Recombinant Human E2F6 Wheat Germ N/A 281 amino acids
Human E2F6-12249H Recombinant Human E2F6, GST-tagged E.coli GST 1-281a.a.
Human E2F6-521HCL Recombinant Human E2F6 cell lysate N/A
Human E2F6-135HF Recombinant Full Length Human E2F6 Protein In Vitro Cell Free System 281 amino acids
Mouse E2F6-4935M Recombinant Mouse E2F6 Protein Mammalian Cell His
Mouse E2F6-2599M Recombinant Mouse E2F6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse E2F6-2599M-B Recombinant Mouse E2F6 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey E2F6-475C Recombinant Cynomolgus E2F6 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey E2F6-221C Recombinant Cynomolgus Monkey E2F6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey E2F6-221C-B Recombinant Cynomolgus Monkey E2F6 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque E2F6-1368R Recombinant Rhesus monkey E2F6 Protein, His-tagged Mammalian Cell His
Rhesus Macaque E2F6-1193R-B Recombinant Rhesus Macaque E2F6 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque E2F6-1193R Recombinant Rhesus Macaque E2F6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken E2F6-4519C Recombinant Chicken E2F6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

E2F6 involved in several pathways and played different roles in them. We selected most pathways E2F6 participated on our site, such as Cell cycle, E2F transcription factor network, G1 to S cell cycle control, which may be useful for your reference. Also, other proteins which involved in the same pathway with E2F6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell cycleDCTN3;SMAD4;GORASP2;RBX1;TFDP1;VRK1;TUBGCP3;NCAPH2;CENPQ
E2F transcription factor networkUXT;CES3;TRIM28;CEBPA;HIC1;CBX5;RYBP;E2F4;SMARCA2
G1 to S cell cycle controlMYT1;E2F6;ATF6B;TFDP1B;CDKN1C

E2F6 has several biochemical functions, for example, DNA binding, protein binding, transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by E2F6 itself. We selected most functions E2F6 had, and list some proteins which have the same functions with E2F6. You can find most of the proteins on our site.

Function Related Protein
DNA bindingTCF7L1A;HER5;KDM5A;HOXC1A;THAP7;JUNB;MEIS4.1A;UPF1;SIX9
protein bindingCNOT7;TSPAN6;EIF4G1;FZD5;DYNC1I2;SKA3;ASS1;CLN3;HBA1
transcription corepressor activityCCAR1;ATF7IP;ZHX2;NCOR1;ELK3;TFAP2B;JUB;YY1;SIAH2
transcription factor activity, sequence-specific DNA bindingZIM3;NFE2L2;HINFP;ATF6B;ASCL1B;ZIK1;TADA2A;THRB;TBX10

E2F6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with E2F6 here. Most of them are supplied by our site. Hope this information will be useful for your research of E2F6.

TFDP2; TFDP1; KRTAP10-7; PIK3R3; Ring1; BMI1

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