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E2F8

  • Official Full Name

    E2F transcription factor 8

  • Overview

    This gene encodes a member of a family of transcription factors which regulate the expression of genes required for;progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the;nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been;identified.
  • Synonyms

    E2F8; E2F transcription factor 8; transcription factor E2F8; FLJ23311; E2F 8; E2F family member 82; E2F-8; E2F8_HUMAN; OTTHUMP00000231893; OTTHUMP00000231894; E2F family member 8;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human E2F8-6740HCL Recombinant Human E2F8 293 Cell Lysate HEK293 N/A
Human E2F8-4284H Recombinant Human E2F8 Protein, GST-tagged Wheat Germ GST
Human E2F8-4962HF Recombinant Full Length Human E2F8 Protein, GST-tagged In Vitro Cell Free System GST 431 amino acids
Mouse E2F8-4937M Recombinant Mouse E2F8 Protein Mammalian Cell His
Mouse E2F8-2601M Recombinant Mouse E2F8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse E2F8-2601M-B Recombinant Mouse E2F8 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • E2F8 Related Articles

E2F8 involved in several pathways and played different roles in them. We selected most pathways E2F8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with E2F8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

E2F8 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, core promoter binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by E2F8 itself. We selected most functions E2F8 had, and list some proteins which have the same functions with E2F8. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingFOXJ1;PITX2;ASCL2;SREBF1;MEIS1;DDIT3;MAFB;ALS2CR8;ZBTB7A
core promoter bindingRELB;MTF1;MTA1;KLF4;IRF9;SPI1;HMGA2;MED1;NEUROG3
protein bindingTIMM10;MMS22L;LGR5;TXNDC9;SYT7;SOS1;TK1;IL23R;PPP1CB
protein homodimerization activityNR0B1;S100A10;RAB11FIP4B;S100A5;NPR3;RBM11;UNC13A;CDH13;PSPH
transcription corepressor activityNEUROD2;AJUBA;CREG1;ATN1;RCOR2;SKI;AEBP2;TRIM28;HAND1
transcription factor activity, sequence-specific DNA bindingNFE2L1;CREB1;FOXO3B;GTF3A;FOXG1A;ZNF45;MESPBA;SPIB;TADA2B
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingPROX1B;NFATC4;NFIL3;GFI1;ZFP536;CC2D1B;SPI1;NFIL3-2;ZFPM1

E2F8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with E2F8 here. Most of them are supplied by our site. Hope this information will be useful for your research of E2F8.

TFCP2; FHL3; E2F7; ZDHHC17

Umemura, S; Shirane, M; et al. Overexpression of E2F-5 correlates with a pathological basal phenotype and a worse clinical outcome. BRITISH JOURNAL OF CANCER 100:764-771(2009).
Panchuk, RR; Boiko, NM; et al. Changes in signaling pathways of cell proliferation and apoptosis during NK/Ly lymphoma aging. CELL BIOLOGY INTERNATIONAL 32:1057-1063(2008).
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