E4F1
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Official Full Name
E4F transcription factor 1
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Overview
The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. -
Synonyms
E4F1; E4F transcription factor 1; transcription factor E4F1; E4F; E4F transcription factor 1, isoform CRA_b; P120E4F transcription factor; p50E4F; p120E4F; transcription factor E4F; putative E3 ubiquitin-protein ligase E4F1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
E4F1 involved in several pathways and played different roles in them. We selected most pathways E4F1 participated on our site, such as p53 pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with E4F1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| p53 pathway | FBXO11;SMYD2;KAT8;RASSF1;HUWE1;TRIM28;E4F1;CSNK1G3;CSE1L |
E4F1 has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, cAMP response element binding. Some of the functions are cooperated with other proteins, some of the functions could acted by E4F1 itself. We selected most functions E4F1 had, and list some proteins which have the same functions with E4F1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | HIST1H111L;ZNF18;DNAJC1;TCEA2;HOXD12;FOXM1;SAP30;ZNF26;MIXL1 |
| RNA polymerase II regulatory region sequence-specific DNA binding | ZNF812;RARA;ZFP551;TFAP2D;ZSCAN2;EOMES;PKNOX2;HSF2;SUV39H1 |
| cAMP response element binding | CREB1;ATF2;E4F1;CREB3L3L;CREB3L1;JUN;CREB3L3;ATF6B;CREB3L4 |
| ligase activity | MARCH8;ZNRF2;TRAF7;LRSAM1;WWP2;NEURL3;ZNRF3;EGR2;MYLIPA |
| metal ion binding | ZNF526;TP63;ZNF609A;ROCK1;SPATA21;PRICKLE1A;ZNF565;ZSCAN23;THAP3 |
| protein binding | STAMBPL1;MPL;IMMT;NSMCE2;ARID3B;RFESD;KAT2B;DYX1C1;PPIH |
| transcription coactivator activity | NEUROG3;JUNBB;RNF20;TUBB3;CREBBP;TBPL1;NR1I3;RB1;TDRD3 |
| transcription corepressor activity | BCL11A;HOMEZB;CRYM;SETD8;DDX54;IRF2BP2;HOXC6;E2F6;RARA |
| transcription factor activity, sequence-specific DNA binding | LHX8A;NFIL3;FOSL2;ATF7A;ZNF74;ZNF500;KLF17;ZFY2;ZNF445 |
| transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | SNAI3;ZBTB4;ZEB1;GLIS1;ETV7;HMX1;FOXD3;BCL6AB;ESX1 |
E4F1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with E4F1 here. Most of them are supplied by our site. Hope this information will be useful for your research of E4F1.
RASSF1; gam1_adeg1; ANP32A; lnx2b; X
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