Background
This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF proteins;are involved in B-cell differentiation, bone development and neurogenesis, and may also function as tumor suppressors.;The encoded protein inhibits cell survival through the regulation of genes involved in cell cycle arrest and;apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple malignancies including;glioblastoma multiforme and gastric carcinoma.