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ECT2

  • Official Full Name

    epithelial cell transforming sequence 2 oncogene

  • Overview

    The protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis.
  • Synonyms

    ECT2; epithelial cell transforming sequence 2 oncogene; protein ECT2; ARHGEF31; ECT 2; ECT2 protein; Epithelial Cell Transforming Sequence 2; Epithelial cell transforming sequence 2 oncogene protein; FLJ10461; MGC138291; OTTHUMP00000210539; OTTHUMP00000210684; OTTHUMP00000210685; OTTHUMP00000210686; epithelial cell-transforming sequence 2 oncogene;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ECT2-3040H Recombinant Human ECT2 Protein, GST-tagged Wheat Germ GST
Human ECT2-6728HCL Recombinant Human ECT2 293 Cell Lysate HEK293 N/A
Human ECT2-691H Recombinant Human ECT2 Protein, His-tagged E.coli His Leu166~Arg348
Human ECT2-2823H Recombinant Human ECT2 protein, His-tagged E.coli His 1-350 aa
Mouse ECT2-4977M Recombinant Mouse ECT2 Protein Mammalian Cell His
Mouse Ect2-1661M Recombinant Mouse Ect2 protein, His & GST-tagged E.coli His/GST Leu672~Leu905 (Accession # Q07139)
Mouse ECT2-2632M Recombinant Mouse ECT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ECT2-2632M-B Recombinant Mouse ECT2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ECT2-1170Z Recombinant Zebrafish ECT2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ECT2 Related Articles

ECT2 involved in several pathways and played different roles in them. We selected most pathways ECT2 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE, G alpha (12/13) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ECT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell death signalling via NRAGE, NRIF and NADEITGB3BP;ARHGEF9;ITSN1;ARHGEF3;ARHGAP4;MCF2L;CASP2;AATF;BCL2L11
G alpha (12/13) signalling eventsKALRNB;ADRA1B;ARHGAP4A;ARHGEF9;RHOB;MCF2L;FGD2;PLEKHG2;ARHGEF1B
GPCR downstream signalingCCR9;TAS2R16;PDE10A;EDNRA;TAS2R13;ARHGEF1A;EDN2;PENKA;PMCH
Gastric cancer network 1SMOC2;ECT2;C21orf33;MYBL2;ESM1;LIN9;S100P;ACTL6A;GATS
NRAGE signals death through JNKARHGEF3;OBSCN;FGD4A;AKAP13;ARHGAP4;FGD4;ARHGEF18A;ARHGEF18;PLEKHG2
PLK1 signaling eventsERCC6L;ECT2;BORA;PLK1S1;TCTN2;TPX2;TPT1;SPC24;NDC80
Regulation of RhoA activityFARP1;ABR;NET1;ARHGEF18;OBSCN;MYO9B;ARHGEF25;ECT2;ARHGAP9
Rho GTPase cycleDCLRE1B;FAM13B;MYO9B;PLEKHG2;ARHGAP1;ARHGEF18;ARHGAP12B;ABR;TAGAPA

ECT2 has several biochemical functions, for example, GTPase activator activity, Rho GTPase binding, Rho guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ECT2 itself. We selected most functions ECT2 had, and list some proteins which have the same functions with ECT2. You can find most of the proteins on our site.

Function Related Protein
GTPase activator activityAGFG1A;NIPAL1;RGS11;ARHGAP4A;ASAP1;SMAP2;RGS16;RABGAP1L;AGAP2
Rho GTPase bindingKIF3B;DIAPH1;DIAP1;DIAPH3;DAPK3;ECT2;ROCK2B;INF2;CDC42BPB
Rho guanyl-nucleotide exchange factor activityFGD5;ARHGEF37;DNMBP;ARHGEF10;ARHGEF9B;ARHGEF2;TRIO;KALRN;NET1
protein bindingHSPA2;DDX17;TDP1;NDRG1;RFX3;DSN1;RHOG;SAP30BP;TXLNG
protein homodimerization activityCADM2A;JAM3;XDH;ABCB9;SLC4A1;ABAT;PVRL1B;BHLHE40;CBLN1
signal transducer activityGNAIA;HTR2CL1;GNA12;ZDHHC17;MGAA;PLCB3;VOPP1;TAS2R126;TAAR14F

ECT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ECT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ECT2.

RACGAP1; MYC; NCK1; PIK3R1; GRB2; Ect2; LAMTOR5; GPSM2; SAMD1; RBM45; SKA3

Suzuki, K; Sako, K; et al. Identification of non-Ser/Thr-Pro consensus motifs for Cdk1 and their roles in mitotic regulation of C2H2 zinc finger proteins and Ect2. SCIENTIFIC REPORTS 5:-(2015).
Harandi, OF; Ambros, VR; et al. Control of stem cell self-renewal and differentiation by the heterochronic genes and the cellular asymmetry machinery in Caenorhabditis elegans. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:E287-E296(2015).
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