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EDA

  • Official Full Name

    ectodysplasin A

  • Overview

    The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.
  • Synonyms

    EDA; ectodysplasin A; ectodermal dysplasia 1, anhidrotic , ED1, EDA2, ODT1, oligodontia 1; ectodysplasin-A; ED1 A1; ED1 A2; EDA1; HED; XHED; XLHED; oligodontia 1; ectodermal dysplasia protein; X-linked anhidroitic ectodermal dysplasia protein; ED1; EDA2; ODT1; ED1-A1; ED1-A2; STHAGX1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Escherichia coli
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human cells
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • His|Flag|StrepII
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EDA-260H Active Recombinant Human EDA Mammalian cells N/A
Human EDA-2117H Recombinant Human Ectodysplasin A, FLAG-tagged E.coli Flag
Human EDA-3041H Recombinant Human EDA Protein, His/Flag/StrepII-tagged Human cells His/Flag/StrepII
Human EDA-2082H Recombinant Human Ectodysplasin A, FLAG-tagged HEK293 Flag
Human EDA-4392H-B Recombinant Human EDA Protein Pre-coupled Magnetic Beads HEK293
Human EDA-928H Recombinant Human EDA Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human EDA-4269H Recombinant Human EDA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human EDA-4392H Recombinant Human EDA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Eda-979M Active Recombinant Mouse Eda Protein, His-tagged Mammalian cells His Ala179-Ser391
Mouse EDA-4979M Recombinant Mouse EDA Protein Mammalian Cell His
Mouse Eda-2634M-B Recombinant Mouse Eda Protein Pre-coupled Magnetic Beads HEK293
Mouse Eda-2722M Recombinant Mouse Eda Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Eda-2634M Recombinant Mouse Eda Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Eda-693M Recombinant Mouse Eda Protein, His/GST-tagged E.coli His/GST Pro141~Thr378
Escherichia coli eda-4164E Recombinant Escherichia coli eda protein, His-tagged E.coli His 1-213aa
Mus musculus (Mouse) RFL908MF Recombinant Full Length Mouse Ectodysplasin-A(Eda) Protein, His-Tagged E.coli expression system His Full Length (1-391)
Zebrafish EDA-6523Z Recombinant Zebrafish EDA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EDA Related Articles
  • EDA Related Research Area
  • EDA Related Signal Pathway

EDA involved in several pathways and played different roles in them. We selected most pathways EDA participated on our site, such as Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with EDA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine Signaling in Immune systemCRK;CSF2;NUP35;IL1RN;NRG4;TRIM14;PEBP1;CSK;IFI6
Cytokine-cytokine receptor interactionFlt3l;IL-8;Pdgfa&Pdgfb;CCL4;IL25;IL5RA;CCR3;CXCL5;Il2
Immune SystemGM11711;RNF41;NLRP4B;BTR06;TRIM3;LILRA1;GBP5;CTLA4;TRIM62
TNFR2 non-canonical NF-kB pathwayEDARADD;EDAR;EDA
TNFs bind their physiological receptorsEDARADD;EDA;EDAR

EDA has several biochemical functions, for example, protein binding, receptor binding, tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EDA itself. We selected most functions EDA had, and list some proteins which have the same functions with EDA. You can find most of the proteins on our site.

Function Related Protein
protein bindingNUP107;KIAA1217;PIK3R1;WHSC2;STX8;ZFPL1;TBX18;PSMA3;ZFP346
receptor bindingCALCA;SSFA2;RND1;PTK6B;CD160;SRI;WNT2BB;IL1RAPL1;F2R
tumor necrosis factor receptor bindingEDA;CD70;CD40LG;TRAP1;TRAF6;FASLG;FADD;TNFSF15;LTA

EDA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EDA here. Most of them are supplied by our site. Hope this information will be useful for your research of EDA.

MAL; PLN; ATP6V0C; CYB561; EMP3; LEPROTL1; NIPAL3

Prasanna, RR; Kamalanathan, AS; et al. Development of L-histidine immobilized CIM (R) monolithic disks for purification of immunoglobulin G. JOURNAL OF MOLECULAR RECOGNITION 28:129-141(2015).
Kowalczyk-Quintas, C; Schuepbach-Mallepell, S; et al. Pharmacological Stimulation of Edar Signaling in the Adult Enhances Sebaceous Gland Size and Function. JOURNAL OF INVESTIGATIVE DERMATOLOGY 135:359-368(2015).
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