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EDAR

  • Official Full Name

    ectodysplasin A receptor

  • Overview

    EDAR is a 49 kDa novel receptor of the TNFR family with one phosphorylation site at serine 324 residue and one death domain near the C-terminus (358-431 aa). Mutations in EDAR have been found in several families with autosomal hypohidrotic ectodermal dysp
  • Synonyms

    EDAR; ectodysplasin A receptor; DL, ectodysplasin 1, anhidrotic receptor , ED3; tumor necrosis factor receptor superfamily member EDAR; ED1R; ED5; EDA1R; EDA3; EDA-A1 receptor; downless homolog; ectodysplasin-A receptor; downless, mouse, homolog of;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • Fc
  • hFc
  • GST
  • His
  • His (Fc)
  • Avi
  • His|Flag|StrepII
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EDAR-601H Active Recombinant Human EDAR, Fc-tagged, Biotinylated Human Cell Fc
Human EDAR-2119H Recombinant Human Ectodysplasin A Receptor, Fc Chimera E.coli Fc
Human EDAR-1607H Recombinant Human Ectodysplasin A Receptor Mammalian cells N/A
Human EDAR-231H Active Recombinant Human EDAR, Fc-tagged CHO Fc
Human EDAR-3135H Recombinant Human EDAR protein(Met1-Ile189), hFc-tagged HEK293 C-hFc Met1-Ile189
Human EDAR-606H Recombinant Human ectodysplasin A receptor, His-tagged E.coli His
Human EDAR-12275H Recombinant Human EDAR, GST-tagged E.coli GST 207-448a.a.
Human EDAR-3215H Recombinant Human EDAR protein, His-tagged HEK293 His Met1-Ile189
Human EDAR-3047H Active Recombinant Human EDAR Protein, His/Flag/StrepII-tagged Human cells His/Flag/StrepII
Human EDAR-3049H Recombinant Human EDAR Protein, GST-tagged Wheat Germ GST
Human EDAR-2247HCL Recombinant Human EDAR cell lysate Human Cell N/A
Human EDAR-782H Recombinant Human EDAR Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human EDAR-921H Recombinant Human EDAR Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human EDAR-0412H Recombinant Human EDAR protein, His-tagged E.coli His 207-448 aa
Human EDAR-1402H Recombinant Human EDAR Protein, His-tagged E.coli N-His Lys212-Ser448
Human EDAR-4394H Recombinant Human EDAR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human EDAR-4394H-B Recombinant Human EDAR Protein Pre-coupled Magnetic Beads HEK293
Mouse EDAR-4981M Recombinant Mouse EDAR Protein Mammalian Cell His
Mouse Edar-1721M Recombinant Mouse Ectodysplasin-A Receptor Mammalian cells N/A
Mouse Edar-10536M-B Recombinant Mouse Edar Protein Pre-coupled Magnetic Beads HEK293
Mouse Edar-10536M Recombinant Mouse Edar Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Edar-5642M Recombinant Mouse Edar Protein (Glu27-Ile189), C-Fc tagged Mammalian cells C-Fc Glu27-Ile189
Mouse Edar-2723M Recombinant Mouse Edar Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Edar-7468R Recombinant Rat Edar protein(Met1-Ala187), hFc-tagged HEK293 C-hFc Met1-Ala187
Rat EDAR-1537RCL Recombinant Rat EDAR cell lysate Human Cell N/A
Cynomolgus EDAR-8833C Recombinant Cynomolgus EDAR protein, hFc-tagged HEK293 hFc Met1-Ala187
Cynomolgus Monkey EDAR-77C Recombinant Cynomolgus EDAR, His tagged Human Cell His
Cynomolgus Monkey EDAR-1021CCL Recombinant Cynomolgus EDAR cell lysate Human Cell N/A
Zebrafish EDAR-6522Z Recombinant Zebrafish EDAR Mammalian Cell His
Chicken EDAR-1980C Recombinant Chicken EDAR Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EDAR Related Articles
  • EDAR Related Gene Family
  • EDAR Related Research Area
  • EDAR Related Signal Pathway

EDAR involved in several pathways and played different roles in them. We selected most pathways EDAR participated on our site, such as Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with EDAR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine Signaling in Immune systemPELI1;EIF4G2;FGF8B;FRS3;BST2;IFIT11;TRIM38;PTPRA;TRIM26
Cytokine-cytokine receptor interactionTNFRSF10A;TNFRSF11B;BMPR1A;CX3CR1;IL13RA1;Ccl21c;GM13305;CCL23;IL18RAP
Immune SystemRNF123;CD300LF;BTR22;LAIR1;TRIM68;TRIM50;LY86;SIGLEC10;LAIR2
Integrated Breast Cancer PathwayZMIZ1;EDAR;GRN;USP38;AHR;NOXA1;DAG1;DHTKD1;ALKBH1
TNFR2 non-canonical NF-kB pathwayEDARADD;EDAR;EDA
TNFs bind their physiological receptorsEDAR;EDA;EDARADD

EDAR has several biochemical functions, for example, protein binding, receptor activity, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EDAR itself. We selected most functions EDAR had, and list some proteins which have the same functions with EDAR. You can find most of the proteins on our site.

Function Related Protein
protein bindingC2orf57;IL6R;AGO3;MON1B;ATP5B;ERCC4;CFTR;RTN4A;PIK3R6
receptor activityROBO4;NR2C2;MED17;MED16;NPR2;NR2C1;NCR3;ADIPOR1A;KRT1
transmembrane signaling receptor activityVIPR1B;TLR6;TLR10;TNFRSF11A;TLR4;TLR2-1;KIR2DS2;TNFRSF10D;MRC1

EDAR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EDAR here. Most of them are supplied by our site. Hope this information will be useful for your research of EDAR.

Traf1; Traf2; TRAF3; EDARADD; EDA; MAP3K14

Kowalczyk-Quintas, C; Schuepbach-Mallepell, S; et al. Pharmacological Stimulation of Edar Signaling in the Adult Enhances Sebaceous Gland Size and Function. JOURNAL OF INVESTIGATIVE DERMATOLOGY 135:359-368(2015).
Hill, G; Headon, D; et al. Pharmacological Activation of the EDA/EDAR Signaling Pathway Restores Salivary Gland Function following Radiation-Induced Damage. PLOS ONE 9:-(2014).
  • Q&As
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