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EDEM2

Official Full Name

ER degradation enhancer, mannosidase alpha-like 2
Overview

In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the;proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in;ERAD of glycoproteins (Mast et al., 2005 (PubMed 15537790)).
Synonyms

EDEM2; ER degradation enhancer, mannosidase alpha-like 2; C20orf31, C20orf49, chromosome 20 open reading frame 31; ER degradation-enhancing alpha-mannosidase-like 2; bA4204.1; FLJ10783; C20orf49; EDEM 2; EDEM2_HUMAN; ER degradation enhancer mannosidase alpha like 2; ER degradation enhancing alpha mannosidase like 2; ER degradation enhancing mannosidase like protein 2; OTTHUMP00000030728; ER degradation-enhancing-mannosidase-like protein 2; C20orf31;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rhesus Macaque

Source

HEK293
Human Cell
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	EDEM2-196H	Recombinant Human EDEM2, His tagged	Human Cell	His		Inquiry
Human	EDEM2-3051H	Recombinant Human EDEM2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	EDEM2-862HCL	Recombinant Human EDEM2 cell lysate	Human Cell	N/A		Inquiry
Human	EDEM2-4185HF	Recombinant Full Length Human EDEM2 Protein, GST-tagged	In Vitro Cell Free System	GST	578 amino acids	Inquiry
Rhesus Macaque	EDEM2-1377R	Recombinant Rhesus monkey EDEM2 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	EDEM2-1202R	Recombinant Rhesus Macaque EDEM2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	EDEM2-1202R-B	Recombinant Rhesus Macaque EDEM2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

EDEM2 involved in several pathways and played different roles in them. We selected most pathways EDEM2 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with EDEM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Protein processing in endoplasmic reticulum	UBQLN3;DNAJB11;NGLY1;RPN1;FBXO2;BCL2;UFD1L;GSBP9;PDIA4

EDEM2 has several biochemical functions, for example, calcium ion binding, glycoprotein binding, NOT mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EDEM2 itself. We selected most functions EDEM2 had, and list some proteins which have the same functions with EDEM2. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	CABP4;BRAF;S100A4;ITSN2A;MACF1;S100T;CDH19;SCUBE2;RASGRP2
glycoprotein binding	TFR2;THBS1;PIP;CD4;CDH1;CANX;FBXO27;BMPR1A;RAB14
NOT mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	MAN1A2;MAN1B1;MAN1A;MAN1C1;EDEM2;MAN1A1;EDEM1

EDEM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EDEM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EDEM2.

RPS3A