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EEA1

  • Official Full Name

    early endosome antigen 1

  • Overview

    Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
  • Synonyms

    EEA1; early endosome antigen 1; MST105; ZFYVE2; MSTP105; early endosome antigen 1, 162kD; endosome-associated protein p162; early endosome-associated protein; zinc finger FYVE domain-containing protein 2;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EEA1-26H Recombinant Human EEA1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human EEA1-28464TH Recombinant Human EEA1 Wheat Germ N/A 100 amino acids
Human EEA1-3902H Recombinant Human EEA1 protein, His-tagged E.coli His His1232~Lys1348
Human EEA1-9389HFL Recombinant Full Length Human EEA1 protein, Flag-tagged Mamanlian cells Flag
Human EEA1-301519H Recombinant Human EEA1 protein, GST-tagged E.coli GST Lys1151-Ala1350
Mouse EEA1-4996M Recombinant Mouse EEA1 Protein Mammalian Cell His
Mouse Eea1-2731M Recombinant Mouse Eea1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse EEA1-2643M Recombinant Mouse EEA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse EEA1-2643M-B Recombinant Mouse EEA1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EEA1 Related Articles
  • EEA1 Related Research Area

EEA1 involved in several pathways and played different roles in them. We selected most pathways EEA1 participated on our site, such as Endocytosis, Phagosome, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with EEA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EndocytosisCLTCB;SMURF2;RHOAD;TSG101;ADRBK2;GIT2B;STAMBPB;LDLRAP1B;CXCR2
PhagosomeTUBA8;H2-AB1;DYNC1LI1;C1RA;HGS;CD14;CTSSB.2;ABCB3L1;HLA-DPA1
TuberculosisTGFB3;HLA-DRB5;IFNA2;BAD;SRC;IL10RB;IFNA14;RAF1;KSR1

EEA1 has several biochemical functions, for example, 1-phosphatidylinositol binding, GTP-dependent protein binding, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EEA1 itself. We selected most functions EEA1 had, and list some proteins which have the same functions with EEA1. You can find most of the proteins on our site.

Function Related Protein
1-phosphatidylinositol bindingPICALM;ZFYVE9;MCF2L;PLEKHA2;SCARB1;SNAP91;WDFY3;SNX9;SCIN
GTP-dependent protein bindingAP3B1;RASGRP4;RAB5B;MRAS;PPIAL4A;PARD6A;RAPGEF5;CDC42;HPS6
calmodulin bindingNOS2;KCNQ1;RGS16;EPB41B;ORAI1;MYO6;MYH9;PHKG2;REM1
protein bindingPTPN11A;PKHD1L1;CUL3;TBCEL;RFC4;UHMK1;LAMP1;KRAS;ODC1
protein homodimerization activityADRB3;SLC14A2;CAV2;NR6A1;IKZF3;TERF2;HSP90AA1;GZMA;DSCAML1
zinc ion bindingCA5A;RNF125;CA4A;TLL1;PGLYRP6;ADAM9;PGLYRP5;LNX1;NANOS1

EEA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EEA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EEA1.

RAB5A; Stx6; ERBB2; RAB5B; SAMD9; Samd9l

Rush, JS; Ceresa, BP; et al. RAB7 and TSG101 are required for the constitutive recycling of unliganded EGFRs via distinct mechanisms. MOLECULAR AND CELLULAR ENDOCRINOLOGY 381:188-197(2013).
Sandgren, KJ; Smed-Sorensen, A; et al. Human Plasmacytoid Dendritic Cells Efficiently Capture HIV-1 Envelope Glycoproteins via CD4 for Antigen Presentation. JOURNAL OF IMMUNOLOGY 191:60-69(2013).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does EEA1 protein relate to neurodegenerative disorders? 11/19/2022

EEA1 protein has been implicated in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease, where abnormal endosome trafficking may contribute to disease progression.

Are there any diagnostic applications of EEA1 protein in neurodegenerative disorders? 10/27/2022

EEA1 protein expression and localization may serve as a potential diagnostic marker for certain neurodegenerative disorders, offering insights into disease pathology.

Can targeting EEA1 protein offer potential therapeutic avenues for neurodegenerative disorders? 06/22/2019

Research suggests that modulating EEA1 protein function may hold promise as a therapeutic approach for neurodegenerative disorders, although further investigation is needed.

How does EEA1 protein function in infectious diseases? 06/09/2019

EEA1 protein plays a critical role in the intracellular trafficking of pathogens, including viruses and bacteria, and its dysregulation can impact the outcome of infectious diseases.

How is EEA1 protein expressed in cancer cells? 12/21/2018

In cancer cells, EEA1 protein expression levels can be altered, leading to abnormal endosome trafficking and potential implications for tumor growth and metastasis.

Customer Reviews (3)

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Reviews
10/04/2020

    In protein electron microscopy structure analysis, the EEA1 protein demonstrates outstanding performance.

    09/25/2020

      the EEA1 protein's versatility allows it to be effectively employed in various experimental designs, further enhancing its suitability for diverse research needs.

      02/09/2020

        Their extensive knowledge and expertise can help troubleshoot issues or provide guidance on experimental design, enabling you to overcome obstacles and achieve your research goals.

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