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EGR1

  • Official Full Name

    early growth response 1

  • Overview

    The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    EGR1; early growth response 1; TIS8; AT225; G0S30; NGFI-A; ZNF225; KROX-24; ZIF-268; early growth response protein 1; EGR-1; zinc finger protein 225; transcription factor ETR103; transcription factor Zif268; zinc finger protein Krox-24; nerve growth factor-induced protein A;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • B2M
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EGR1-52 Recombinant Human EGR1 protein, His-tagged E.coli His
Human EGR1-2120H Recombinant Human Early Growth Response 1 Sf9 Insect Cell N/A
Human EGR1-28467TH Recombinant Human EGR1 Wheat Germ N/A 100 amino acids
Human EGR1-3121H Recombinant Human EGR1 Protein, GST-tagged Wheat Germ GST
Human EGR1-628H Recombinant Human EGR1 Protein, His-tagged E.coli His Gln282~Ser433
Human EGR1-6692HCL Recombinant Human EGR1 293 Cell Lysate HEK293 N/A
Human EGR1-2841H Recombinant Human EGR1 protein, His-B2M-tagged E.coli His-B2M 444-543aa
Human EGR1-1384H Recombinant Human EGR1 Protein (444-543 aa), His-tagged Yeast His 444-543 aa
Human EGR1-4264HF Recombinant Full Length Human EGR1 Protein, GST-tagged In Vitro Cell Free System GST 543 amino acids
Human EGR1-2047H Recombinant Human EGR1 Protein (Gln282-Ser433), His tagged E.coli His Gln282-Ser433
Mouse Egr1-629M Recombinant Mouse Egr1 Protein, His-tagged E.coli His Gln273~Ser431
Mouse EGR1-5052M Recombinant Mouse EGR1 Protein Mammalian Cell His
Mouse EGR1-2682M-B Recombinant Mouse EGR1 Protein Pre-coupled Magnetic Beads HEK293
Mouse EGR1-2682M Recombinant Mouse EGR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat EGR1-2032R Recombinant Rat EGR1 Protein Mammalian Cell His
Rat EGR1-1689R-B Recombinant Rat EGR1 Protein Pre-coupled Magnetic Beads HEK293
Rat EGR1-1689R Recombinant Rat EGR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque EGR1-1399R Recombinant Rhesus monkey EGR1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque EGR1-1224R Recombinant Rhesus Macaque EGR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque EGR1-1224R-B Recombinant Rhesus Macaque EGR1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish EGR1-8845Z Recombinant Zebrafish EGR1 Mammalian Cell His
Chicken EGR1-5712C Recombinant Chicken EGR1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EGR1 Related Articles
  • EGR1 Related Research Area

EGR1 involved in several pathways and played different roles in them. We selected most pathways EGR1 participated on our site, such as BDNF signaling pathway, Calcineurin-regulated NFAT-dependent transcription in lymphocytes, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with EGR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
BDNF signaling pathwayEGR2;GRIP1;BCL2L11;SYN1;EIF2S1;CSNK2A1;CDH2;CSNK2A1P;LINGO1
Calcineurin-regulated NFAT-dependent transcription in lymphocytesBATF3;EGR3;DGKA;CSF2;JUNB;EGR4;IKZF1;EGR1;EGR2
Cytokine Signaling in Immune systemRASGRP4;CSHL1;SPRED1;EIF4EB;IRF4;KPNA3;IL1RN;HAVCR2;PELI1
Downstream signaling in naive CD8+ T cellsJUNB;EGR4;EGR1;EOMES
ErbB1 downstream signalingACTR3;BAIAP2;ACTR2;WASF2;ARF4;EPS8;ABI1;CHN2;EGR1
Glucocorticoid receptor regulatory networkCSN2;BGLAP;POU2F1;KRT5;KRT14;NR1I3;SMARCA4;KRT17;EGR1
HTLV-I infectionMAPK8;PIK3CB;VDAC2;BCL2L1;WNT7B;WNT8A;SPI1;ETS2;WNT7A
Immune SystemKLHL20;NLRP4;Txn1;CD300LD;PAG1;TRIM5;TPP2;IFI30;UBR1

EGR1 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EGR1 itself. We selected most functions EGR1 had, and list some proteins which have the same functions with EGR1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingNOSTRIN;ZNF43;LHX1A;ZNF692;GATA4;ZNF577;SSH3;ZFP629;UBP1
RNA polymerase II core promoter sequence-specific DNA bindingH2AFY;NFIL3;SOX11;H3F3A;MTF1;SPI1;HOXB3;IRF7;NLRC5
RNA polymerase II regulatory region sequence-specific DNA bindingPRDM12B;DBP;GATA2B;EAF2;RORA;NEUROD2;ZSCAN20;MEF2D;ETV6
histone acetyltransferase bindingMTF1;TRIP4;ZBTB7A;ETS1;KAT2B;TAF7L;GLI3;MEF2A;CITED2
metal ion bindingTNNI3;TRMT1;SLC8A1;DZIP1L;HNRNPA0L;ZDHHC5A;RASA3;GH1;ZFC3H1
protein bindingRASL11A;NCL;NPAS2;GPRASP2;CHIC2;C5orf30;HSPA13;RABGAP1;FAM60A
sequence-specific DNA bindingPOUV;FOXN2;RXRGB;NR1D2B;HOXD1;GLI1;FOXA3;HOXB2;PRRX1B
transcription factor activity, sequence-specific DNA bindingPOU4F2;NR1D4A;CBFB;ZSCAN4C;SNAPC5;HIF1A;TEAD3;ZNF37A;ZFP639
transcription factor bindingCEBPA;PPP1R13BA;CREG1;PPARGC1A;PYDC3;PBX2;HDAC5;DRAP1;ENPP2
transcription regulatory region sequence-specific DNA bindingNR5A1A;BACH1B;NFE2L1B;HDAC1;NFE2L2;FOXN1;NFKB1;MEF2AA;GATA3
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingPITX2;SRF;DBP;CEBPA;ELK3;MAFA;EBF2;RFX4;BCL11B

EGR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EGR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EGR1.

CDKN2A; CTNNB1; SNAI1; SP1; SUMO1; SREBF2; nos; astD; MAGEB2; MED6; DNAJC8

Vogels, RJC; Vlenterie, M; et al. Solitary fibrous tumor - clinicopathologic, immunohistochemical and molecular analysis of 28 cases. DIAGNOSTIC PATHOLOGY 9:-(2014).
Prast, JM; Schardl, A; et al. Reacquisition of cocaine conditioned place preference and its inhibition by previous social interaction preferentially affect D1-medium spiny neurons in the accumbens corridor. FRONTIERS IN BEHAVIORAL NEUROSCIENCE 8:-(2014).
  • Q&As
  • Reviews

Q&As (7)

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What therapeutic strategies are being explored targeting EGR1 in various diseases? 04/16/2022

Therapeutic strategies targeting EGR1 are being explored in cancer, neurological disorders, and cardiovascular diseases, aiming to modulate its activity for therapeutic benefit.

How is dysregulation of EGR1 associated with cancer? 09/06/2021

Dysregulation of EGR1 has been associated with various cancers, where it can function as either a tumor suppressor or oncogene depending on context.

What role does EGR1 play in cellular proliferation and differentiation? 05/04/2020

EGR1 promotes cellular proliferation and plays a role in the initiation of cellular differentiation.

What is the main function of EGR1 in cellular processes? 03/08/2020

EGR1 functions as a transcription factor, regulating the expression of genes involved in cell growth, differentiation, and response to stimuli.

How is EGR1 implicated in the cellular stress response? 01/23/2020

EGR1 is a critical component of the immediate-early response to cellular stress, aiding in the activation of genes required for survival and repair.

In what way does EGR1 contribute to synaptic plasticity and learning? 01/08/2020

In the nervous system, EGR1 is involved in synaptic plasticity, contributing to learning and memory processes.

How is EGR1 expression regulated in response to external stimuli? 04/06/2019

EGR1 expression is rapidly induced in response to a variety of external signals, including growth factors, stress, and hormonal stimuli.

Customer Reviews (3)

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Reviews
02/25/2020

    Perfect for cell assays.

    10/07/2019

      Great in biochemical studies.

      11/23/2018

        High quality, great performance.

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