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EIF2B1

  • Official Full Name

    eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa

  • Overview

    This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Oct 2009]
  • Synonyms

    EIF2B1; eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa; EIF2B; EIF2BA; translation initiation factor eIF-2B subunit alpha; eIF-2B GDP-GTP exchange factor subunit alpha;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EIF2B1-3511H Recombinant Human EIF2B1, His-tagged E.coli His
Human EIF2B1-3155H Recombinant Human EIF2B1 Protein, GST-tagged Wheat Germ GST
Human EIF2B1-539HCL Recombinant Human EIF2B1 cell lysate N/A
Human EIF2B1-4443H Recombinant Human EIF2B1 protein, GST-tagged E.coli GST 1-305aa
Human EIF2B1-4489HF Recombinant Full Length Human EIF2B1 Protein, GST-tagged In Vitro Cell Free System GST 305 amino acids
Rat EIF2B1-2046R Recombinant Rat EIF2B1 Protein Mammalian Cell His
Rat EIF2B1-1703R Recombinant Rat EIF2B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat EIF2B1-1703R-B Recombinant Rat EIF2B1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey EIF2B1-485C Recombinant Cynomolgus EIF2B1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey EIF2B1-230C Recombinant Cynomolgus Monkey EIF2B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey EIF2B1-230C-B Recombinant Cynomolgus Monkey EIF2B1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish EIF2B1-294Z Recombinant Zebrafish EIF2B1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EIF2B1 Related Articles

EIF2B1 involved in several pathways and played different roles in them. We selected most pathways EIF2B1 participated on our site, such as Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cap-dependent Translation InitiationEIF2B1;EIF2S1A;EIF4B;EIF1AXA;RPL35;EIF5;EIF4A2;EIF4A1;EIF4H
Eukaryotic Translation InitiationEIF2B1;EIF3K;FAUB;EIF2S1A;EIF2S3;EIF4H;EIF4A1;EIF4G1;EIF5
Gene ExpressionZNF577;TNRC6B;RARAB;ADARB1;ZNF738;NR1D2B;COX14;ZNF620;A1CF
Metabolism of proteinsMPDU1A;GALNT6;EXOC8;ATP6AP2;MUC5AC;SPCS3;DDIT3;IGF2B;CPA3
RNA transportNUP155;PNN;CLNS1A;EIF4EBP3L;NCBP1;EIF5B;EIF3A;UBE2IA;PABPC3
Recycling of eIF2:GDP
TranslationAPEH;EIF2B1;EEF1D;EEF1G;EEF1A2;EIF5;EEF1B2
Translation FactorsEEF1G;EIF4EBP2;EIF5A;EEF1A2;EEF1D;EEF1B2;PAIP1;EIF1;EEF2B

EIF2B1 has several biochemical functions, for example, GDP binding, GTP binding, NOT S-methyl-5-thioribose-1-phosphate isomerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2B1 itself. We selected most functions EIF2B1 had, and list some proteins which have the same functions with EIF2B1. You can find most of the proteins on our site.

Function Related Protein
GDP bindingRAB31;ARL8B;RAB21;IIGP1;RALB;RAB27A;MIEF1;RAB11B;RAP2C
GTP bindingSEPT8B;RAB18A;DNM3;RAB44;TUBA7L;RAB39BA;GNAO1;MB21D1;RAB5C
NOT S-methyl-5-thioribose-1-phosphate isomerase activityEIF2B3;EIF2B4;EIF2B2;EIF2B1
enzyme regulator activityPSMD1;RGN;DPM2;PSMD2;ATP6V1H;MTMR9;BRCC3;GCLM;CPN2
contributes_to guanyl-nucleotide exchange factor activityEIF2B3;HBXIP;EIF2B1;EIF2B2;EIF2B4;LAMTOR1;LAMTOR2;EIF2B5;ALS2
protein bindingC4orf19;C17orf59;BMP1;TNNC2;RHOG;SH3GL1;ADAR;C3orf52;NDE1
contributes_to translation initiation factor activityEIF3S6IP;EIF3S10;EIF3BA;EIF2B5;EIF3A;EIF3B;EIF3L;EIF3EA;EIF2B2

EIF2B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2B1.

RD3; WDYHV1; GORASP2; Adra2b; Adra2a; ADRB2; 7242199; PDIA4; HNRNPL; Adrb2

Robinson, ME; Rossignol, E; et al. Vanishing White Matter Disease in French-Canadian Patients From Quebec. PEDIATRIC NEUROLOGY 51:225-232(2014).
Zahoor, I; Hamid, Z; et al. Novel mutations identified in EIF2B5 gene in Kashmiri patients as susceptibility factor for multiple sclerosis. INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS 51:115-120(2014).
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