EIF6
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Official Full Name
eukaryotic translation initiation factor 6
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Overview
Eukaryotic initiation factor 6 (eIF6) is reqiured for the 60S ribosomal subunit assembly in the nucleolus. In the cytoplasm, this protein is bound to 60S ribosome subunits and prevents them from joining 40S ribosome subunits to form 80S ribosomes. eIF6 is -
Synonyms
EIF6; eukaryotic translation initiation factor 6; EIF3A, integrin beta 4 binding protein , ITGB4BP; b(2)gcn; p27BBP; B4 integrin interactor; p27 beta-4 integrin-binding protein; eukaryotic translation initiation factor 3A; CAB; EIF3A; eIF-6; ITGB4BP; p27;
- Recombinant Proteins
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- Protein Pre-coupled Magnetic Beads
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- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
- EIF6 Related Articles
EIF6 involved in several pathways and played different roles in them. We selected most pathways EIF6 participated on our site, such as Ribosome biogenesis in eukaryotes, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Ribosome biogenesis in eukaryotes | LOC81691;FBLL1;LSG1;RBM28;RPP30;NXT1;NOP56;NHP2L1;GNL2 |
EIF6 has several biochemical functions, for example, protein binding, ribosomal large subunit binding, ribosome binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF6 itself. We selected most functions EIF6 had, and list some proteins which have the same functions with EIF6. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | IFT57;TP73;HIST1H3A;ABI2;KRAS;TEX10;SH3GL1;HRASLS5;KCTD1 |
ribosomal large subunit binding | MRRF;OLA1;NMD3;EIF6;RBM3;MALSU1;CPEB2;NPM1 |
ribosome binding | MTRF1L;RPSA;YTHDF1;EIF6;MTOR;EFTUD1;EIF2A;CPEB2;IGHMBP2 |
translation initiation factor activity | EIF4A1B;EIF4EA;EIF5B;EIF1AD;EIF4EB;EIF4G2;GTPBP1L;EIF2S1B;EIF5 |
EIF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF6.
NREP; EIF2AK2; DHX58; OAS3; Prkcb; q96nr0_human
- Q&As
- Reviews
Q&As (7)
Ask a questionEIF6 helps cells respond to stress, adapting protein synthesis under nutrient deprivation or hypoxic conditions.
EIF6 is crucial for ribosome assembly and regulates the initiation of protein synthesis in eukaryotic cells.
EIF6 plays a role in selectively controlling the translation of specific mRNA molecules.
EIF6 contributes to cellular growth by facilitating efficient protein synthesis, necessary for cell proliferation.
Changes in EIF6 activity can impact metabolic processes, potentially leading to the development of metabolic disorders.
Dysregulation of EIF6 can lead to abnormal protein synthesis, contributing to cancer development and progression.
EIF6 influences cell cycle and differentiation by modulating the synthesis of key regulatory proteins.
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