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ELA2

Official Full Name

elastase, neutrophil expressed
Overview

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.
Synonyms

NE; Ela2; F430011M15Rik;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Zebrafish	ELA2-7228Z	Recombinant Zebrafish ELA2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

ELA2 involved in several pathways and played different roles in them. We selected most pathways ELA2 participated on our site, such as Cobalamin (Cbl, vitamin B12) transport and metabolism, Metabolism, Metabolism of vitamins and cofactors, which may be useful for your reference. Also, other proteins which involved in the same pathway with ELA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cobalamin (Cbl, vitamin B12) transport and metabolism	ELA2;MTRR;CBLC-1;MMADHC;AMN;ELA2L;LOC100686744;CTRB1;TCN1
Metabolism	APOA4B.1;PEMT;ATP5S;SLC25A15A;LRPPRC;AKR1B15;ARSH;TIAM2;PIK3R6
Metabolism of vitamins and cofactors	SLC46A1;CYB5A;GPHN;ELA2L;CBLC-1;SLC25A16;CTRC;SLC2A3;SLC25A32
Metabolism of water-soluble vitamins and cofactors	NAMPT;SLC46A1;CD320;SLC25A32B;SLC19A2;CTRB1;PDZD11;SLC25A32A;SLC23A2

ELA2 has several biochemical functions, for example, hydrolase activity, peptidase activity, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ELA2 itself. We selected most functions ELA2 had, and list some proteins which have the same functions with ELA2. You can find most of the proteins on our site.

Function	Related Protein
hydrolase activity	PROCA;POR;Ctsl;OTUB1A;UFSP2;STAMBPA;PLCD1B;URAH;PPP3CB
peptidase activity	PRSS41;ADAMTS7;PRSS52;KLK1B1;F2RL1.2;CAPN2B;C1RA;Shh;CAPN12
serine-type endopeptidase activity	CTSC;TMPRSS11B;FAM108A1;TYSND1;KLK13;PRSS52;TMPRSS4B;KLK1B4;CLPP
serine-type peptidase activity	Reln;C1rb;TMPRSS11G;PRSS8;KLK12;FURINB;IMMP2L;KLK1B3;RBP3

ELA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ELA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ELA2.