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EME1

Official Full Name

essential meiotic endonuclease 1 homolog 1 (S. pombe)
Overview

This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.
Synonyms

EME1; essential meiotic endonuclease 1 homolog 1 (S. pombe); crossover junction endonuclease EME1; FLJ31364; MMS4L; SLX2 structure specific endonuclease subunit homolog A (S. cerevisiae); SLX2A; 6820428D13; EC 3.1.22.-; Eme1 essential meiotic endonuclease 1 homolog 1 (S. pombe); EME1, S. pombe, homolog of, 1; essential meiotic endonuclease 1 homolog 1 (S pombe); Essential Meiotic Endonuclease 1 Homolog 1; essential meiotic endonuclease 1 homolog 2; Essential meiotic endonuclease 1, S. pombe, homolog of, 1; hMMS4; homolog of yeast EME1 endonuclease; MGC106543; MMS4; MMS4 homolog; OTTHUMP00000221188; OTTHUMP00000221189; OTTHUMP00000221193; SLX2 structure-specific endonuclease subunit homolog A;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|SUMO
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	EME1-3275H	Recombinant Human EME1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	EME1-12431H	Recombinant Human EME1, GST-tagged	E.coli	GST	C-term-350a.a.	$319 / 25ug
Human	EME1-552HCL	Recombinant Human EME1 cell lysate		N/A		Inquiry
Human	EME1-1106H	Recombinant Human EME1 Protein (1-583 aa), His-SUMO-tagged	E.coli	His/SUMO	1-583 aa	Inquiry
Human	EME1-4234HF	Recombinant Full Length Human EME1 Protein, GST-tagged	In Vitro Cell Free System	GST	583 amino acids	Inquiry
Mouse	EME1-5171M	Recombinant Mouse EME1 Protein	Mammalian Cell	His		Inquiry
Mouse	EME1-2768M	Recombinant Mouse EME1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	EME1-2768M-B	Recombinant Mouse EME1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

EME1 involved in several pathways and played different roles in them. We selected most pathways EME1 participated on our site, such as DNA Double-Strand Break Repair, DNA Repair, Fanconi Anemia Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EME1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
DNA Double-Strand Break Repair	RAD51AP1;EYA3;POLD3;RTEL1;WRN;RAD9B;CHEK1;PPP4R2A;PARP2
DNA Repair	PPP4CA;TIPIN;KDM4B;BAZ1B;INO80;CLSPN;BRCC3;TP53BP1;SPRTN
Fanconi Anemia Pathway	FANCM;BRCA1;USP1;HES1;USP36;FANCB;C19orf40;POLH;REV3L
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)	RHNO1;FUZ;FAM175A;TP53BP1;PPP4R2B;UIMC1;PPP4R2A;THRSP;BRE
HDR through Homologous Recombination (HRR)	KIAA0146;RAD51AP1;RHNO1;HUS1;RTEL1;WRN;EME2;RBBP8;RAD9B
Homologous recombination	RPA4;RAD52;CDK5R2;RAD51L1;RPA2;RAD54B;POLD4;RAD51D;BLM
Homology Directed Repair	RAD51AP1;PPP4CA;KIAA0146;GEN1;RNF4;PPP4CB;WRN;RHNO1;FUZ

EME1 has several biochemical functions, for example, DNA binding, endonuclease activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EME1 itself. We selected most functions EME1 had, and list some proteins which have the same functions with EME1. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	ASCL1;FOXB1B;NFE2L2;ZFP36L1;FOXN2B;ZNF69;NKX2.3;PMS1;CRAMP1L
endonuclease activity	EAR2;DIS3;CENPT;EXOG;RNASE7;EAR5;PPP1R8;RNASEKA;RNASE4
metal ion binding	CTDSP1;TRMT1;CYP4V7;Adamts19;STK24;JUB;ALDH1A2;PELO;ADCY9
protein binding	ADAM10;RBM39;MMP20;KLHL41;RGP1;POT1A;HYPK;WDFY2;BTBD1

EME1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EME1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EME1.

MUS81; SLX4; y-structure-oligo-1; DDB1; Srp72; Nek2; Shoc2; YEATS4; vpr; USF1; PML; FEN1