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EN1

  • Official Full Name

    engrailed homeobox 1

  • Overview

    Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the engrailed (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]
  • Synonyms

    EN1; engrailed homeobox 1; homeobox protein engrailed-1; hu-En-1; engrailed homolog 1; homeobox protein en-1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His|B2M
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EN1-3297H Recombinant Human EN1 Protein, GST-tagged Wheat Germ GST
Human EN1-4285HF Recombinant Full Length Human EN1 Protein, GST-tagged In Vitro Cell Free System GST 392 amino acids
Human EN1-301198H Recombinant Human EN1 protein, GST-tagged E.coli GST Met109-Asn197
Human EN1-2963H Recombinant Human EN1 Protein (Met1-Glu392), C-His tagged E.coli C-His Met1-Glu392
Mouse EN1-5191M Recombinant Mouse EN1 Protein Mammalian Cell His
Mouse EN1-2784M Recombinant Mouse EN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse EN1-2784M-B Recombinant Mouse EN1 Protein Pre-coupled Magnetic Beads HEK293
Chicken EN1-1199C Recombinant Chicken EN1 Protein, His-B2M-tagged E.coli His/B2M
  • Involved Pathway
  • Protein Function
  • Interacting Protein

EN1 involved in several pathways and played different roles in them. We selected most pathways EN1 participated on our site, such as Dopminergic Neurogenesis, SIDS Susceptibility Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with EN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Dopminergic NeurogenesisEN2;EN1
SIDS Susceptibility PathwaysRUNX3;CC2D1A;PHOX2A;KCNQ1;TPPP;PKNOX1;CREM;TPH2;SNTA1

EN1 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EN1 itself. We selected most functions EN1 had, and list some proteins which have the same functions with EN1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZBTB48;EGR4;HIST1H2AG;EN1;PHTF2;GPBP1;ZFP354A;POLR2EB;POLR2H
RNA polymerase II core promoter proximal region sequence-specific DNA bindingTCF3B;MYF5;HLTF;NCOA2;CRX;HOXA10;ZNF502;JUNBA;BCL11B
protein bindingADAM10;KRTAP10-9;SMAD5;ASPH;CACNA1SB;PEX6;ZBTB1;GCH1;COP1
sequence-specific DNA bindingARXA;SIX4A;PRRX1A;HOXB3A;ESX1;VDRB;RARAA;DLX2B;NR1H3
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingZFPM1;SNAI1;BCL11AB;SNAI2;PROX1A;NFATC4;ETS2;PROX1B;GZF1

EN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EN1.

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