ENPP7
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Official Full Name
ectonucleotide pyrophosphatase/phosphodiesterase 7
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Overview
Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (E-NPP 7) also known as alkaline sphingomyelin phosphodiesterase (Alk-SMase) or intestinal alkaline sphingomyelinase is an enzyme that in humans is encoded by the ENPP7 gene. -
Synonyms
ENPP7; ectonucleotide pyrophosphatase/phosphodiesterase 7; ectonucleotide pyrophosphatase/phosphodiesterase family member 7; alk SMase; Alkaline sphingomyelin phosphodiesterase; Intestinal alkaline sphingomyelinase; NPP-7; E-NPP 7; alkaline sphingomyelinase; ALK-SMase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Homo sapiens (Human)
- Human
- Mouse
- Rat
- Rattus norvegicus (Rat)
- E.coli
- E.coli expression system
- HEK293
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- N/A
- N
- Background
- Quality Guarantee
- Case Study
- Involved Pathway
- Protein Function
- Interacting Protein
- ENPP7 Related Research Area
Fig1: Comparison of the Enzymes in the NPP Family. (Jianxin Duan, 2010)
What is ENPP7 protein?
ENPP7 (ectonucleotide pyrophosphatase/phosphodiesterase 7) gene is a protein coding gene which situated on the long arm of chromosome 17 at locus 17q25. Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7), also known as alkaline sphingomyelinase (Alk-Smase), is a member of nucleotide phosphodiesterase (NPP) family and is expressed in the intestines and humanbile. ENPP7 is a single-passtypeⅠmembrane protein, and islocalized at th esurface of the microvilla membrane in small lintestine enterocytes, as well as in endosome-like structures and in Golgicomplex. The ENPP7 protein is consisted of 458 amino acids and its molecular mass is approximately 51.5 kDa.
What is the function of ENPP7 protein?
The protein encoded by the ENPP7 gene is an intestinal alkaline sphingomyelin phosphodiesterase that converts sphingomyelin to ceramide and phosphocholine. The encoded protein ENPP7, is anchored in the cell membrane, and it may function to protect the intestinal mucosa from inflammation and tumorigenesis. This protein is glycosylated and also exhibits lysophosphatidylcholine hydrolase activity.
ENPP7 Related Signaling Pathway
Among its related pathways are sphingolipid metabolism and metabolism. It is also related to intracellular signaling, especially in the processes of cellular stress response, apoptosis and inflammation. Activation or inhibition of these signaling pathways can affect normal cell function and disease state.
ENPP7 Related Diseases
Diseases associated with ENPP7 include Familial Adenomatous Polyposis and Colorectal Cancer. It plays an important role in phospholipid metabolism of nerve cell membrane, and its abnormal activity may lead to the disturbance of phospholipid metabolism of nerve cell membrane, and then affect nerve signal transmission and cell death, leading to Alzheimer's disease, Parkinson's disease, etc. ENPP7 is involved in the regulation of inflammatory response, and its abnormal function may be related to the occurrence and development of inflammatory diseases such as inflammatory bowel disease and rheumatoid arthritis.
Bioapplications of ENPP7
The application of ENPP7 in biology is mainly focused on the research of biological processes and related diseases, including neurobiological research, inflammation and immune response research, tumor biology research, drug development and so on.
High Purity
Fig1. SDS-PAGE (ENPP7-3327H) (PROTOCOL for western blot)
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Fig2. SDS-PAGE (Enpp7-7724R) (PROTOCOL for western blot)
Case Study 1: Jun Wu, 2004
Fig1. The perfusates collected before (fractions 1 and 2) and during trypsin perfusion (fractions 3–5) were subjected to Western blot analysis using anti-human Alk-SMase antibody.
Case Study 2: Rui-Dong Duan, 2003
Fig2. Purity of human intestinal alk-SMase after purification. Lane A, standard protein. Lane B, the original material for purification. Lane C, the purified human intestinal alk-SMase. Lane D, the purified rat intestinal alk-SMase.
ENPP7 involved in several pathways and played different roles in them. We selected most pathways ENPP7 participated on our site, such as Sphingolipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ENPP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Sphingolipid metabolism | PPM1L;SERINC1;LASS1;NEU3.4;PPAP2A;CERS4;ASAH1;SMPD1;CERS2 |
| Metabolic pathways | ADKA;PFKM;AKR1A1A;UGT5G1;HOGA1;CDS1;HEXA;HYI;MAPK1IP1L |
ENPP7 has several biochemical functions, for example, sphingomyelin phosphodiesterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ENPP7 itself. We selected most functions ENPP7 had, and list some proteins which have the same functions with ENPP7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sphingomyelin phosphodiesterase activity | SMPD2A;SMPDL3B;SMPDL3A;SMPD1;SMPD2;ENPP7;SMPD3;SMPD5;SMPD4 |
ENPP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ENPP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of ENPP7.
- Q&As
- Reviews
Q&As (5)
Ask a questionENPP7 levels or activity may serve as biomarkers in diagnosing certain metabolic disorders or assessing cardiovascular risk.
The expression of ENPP7 is regulated by various factors, including diet, hormones, and genetic factors.
Genetic variations in the ENPP7 gene have been linked to certain diseases, including metabolic disorders and cardiovascular conditions.
ENPP7 is thought to play a protective role in atherosclerosis by influencing lipid profiles and reducing the risk of plaque formation in blood vessels.
Research suggests that modulating ENPP7 activity may have therapeutic potential for managing cardiovascular diseases, but further studies are needed.
Customer Reviews (3)
Write a reviewWith their extensive knowledge and expertise, I am assured that any challenges or issues I may encounter during my research will be efficiently resolved.
I am highly impressed with the ENPP7 protein as it is of exceptionally high quality, and I am confident that it will perfectly meet the specific requirements of my experiments.
Such dedicated support makes me feel confident in my choice of using the ENPP7 protein for my experiments.
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