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ENSA

  • Official Full Name

    endosulfine alpha

  • Overview

    The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.
  • Synonyms

    ENSA; endosulfine alpha; alpha-endosulfine; ARPP 19e; MGC4319; MGC8394; MGC78563; Alpha endosulfine; OTTHUMP00000032931; OTTHUMP00000032932; OTTHUMP00000034001; OTTHUMP00000034002; OTTHUMP00000034003; OTTHUMP00000034004; OTTHUMP00000034005; OTTHUMP00000034006; OTTHUMP00000218268; OTTHUMP00000218269; OTTHUMP00000218272; ARPP-19e;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Fc
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ENSA-12464H Recombinant Human ENSA, GST-tagged E.coli GST 1-121a.a.
Human ENSA-28569TH Recombinant Human ENSA protein, His-tagged E.coli His Ser2-Glu121
Human ENSA-539H Recombinant Human ENSA, His tagged E.coli Fc
Human ENSA-3328H Recombinant Human ENSA Protein, GST-tagged Wheat Germ GST
Human ENSA-1838H Recombinant Human Endosulfine Alpha, His-tagged E.coli His
Human ENSA-6593HCL Recombinant Human ENSA 293 Cell Lysate HEK293 N/A
Human ENSA-1710H Recombinant Human ENSA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ENSA-2236H Recombinant Human ENSA protein, His-tagged, Biotinylated E.coli His Met1-Glu121
Human ENSA-4327HF Recombinant Full Length Human ENSA Protein, GST-tagged In Vitro Cell Free System GST 121 amino acids
Mouse Ensa-3364M Recombinant Mouse Ensa, His-tagged E.Coli or Yeast His 117
Mouse ENSA-5215M Recombinant Mouse ENSA Protein Mammalian Cell His
Mouse Ensa-2834M Recombinant Mouse Ensa Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ENSA-2801M Recombinant Mouse ENSA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ENSA-2801M-B Recombinant Mouse ENSA Protein Pre-coupled Magnetic Beads HEK293
Rat ENSA-2108R Recombinant Rat ENSA Protein Mammalian Cell His
Rat ENSA-1765R-B Recombinant Rat ENSA Protein Pre-coupled Magnetic Beads HEK293
Rat ENSA-1765R Recombinant Rat ENSA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken ENSA-1812C Recombinant Chicken ENSA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ENSA involved in several pathways and played different roles in them. We selected most pathways ENSA participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, M Phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with ENSA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell CycleMYBL2;MPEG1.1;MSH5;ENSA;ARF1;ORC4;CSNK2B;ORC6;CENPO
Cell Cycle, MitoticCEP72;TUBGCP4;CSNK2B;CSNK2A2;ESCO1;ZWILCH;ITGB3BP;LMNB1;ARPP19
M PhaseCENPE;DSN1;NEK6;INCENP;NSL1;SGOL2;PANE1;CENPI;NDEL1B
MASTL Facilitates Mitotic ProgressionENSAA;ARPP19;ENSA;ARPP19A;ENSAB;MASTL;ARPP19B
Mitotic ProphaseCTDNEP1B;CTDNEP1A;MCPH1;TMEM188;NEK7;VRK1;NCAPH2;MASTL;ENSA

ENSA has several biochemical functions, for example, ion channel inhibitor activity, phosphatase inhibitor activity, potassium channel inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ENSA itself. We selected most functions ENSA had, and list some proteins which have the same functions with ENSA. You can find most of the proteins on our site.

Function Related Protein
ion channel inhibitor activityRSC1A1;ENSA;PDZD3;KCNV1;STOML1;KCNMB2;GNB2L1
phosphatase inhibitor activityURI1;ENSA;ARPP19;ANP32E;TESC;ENSAA
potassium channel inhibitor activityRASA1;PTI;KCNA5;NEDD4L;KCNK2;ENSA;CAV3
protein bindingAKT1;TSR2;TPM4;MYEF2;EXOC1;NIPSNAP1;E4F1;MT1G;CCDC6
protein phosphatase 2A bindingEIF4EBP1;PPP2R2A;MASTL;TP53;ENSAA;ANKLE2;MAPT;PPP2R4;GRIN3A
protein phosphatase inhibitor activityELFN1;PPP1R35;ENSA;PTN;SAG;SH3RF2;PPP1R1C;PHACTR3;DYSFIP1
protein phosphatase type 2A regulator activityPPP2R5B;PPME1;PPP2R5E;PPP2R5D;PPP2R2A;PPP2R5CB;EIF2AK2;PPP2R5EA;PPP2R2CA
receptor bindingIDUA;F2;NSG1;LPL;SNX17;CCL17;STOML2;ANGPT2;NRG3

ENSA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ENSA here. Most of them are supplied by our site. Hope this information will be useful for your research of ENSA.

ACD; MCM3; CNKSR2; ARIH2; ENO2; RAP2A; PSEN1; KCTD15; POT1

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