EP300
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Official Full Name
E1A binding protein p300
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Overview
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. -
Synonyms
EP300; E1A binding protein p300; histone acetyltransferase p300; KAT3B; p300; p300 HAT; E1A-binding protein, 300kD; E1A-associated protein p300; RSTS2;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Dog
- Human
- Monkey
- Mouse
- Rat
- Rhesus Macaque
- E. coli
- E.coli
- HEK293
- Insect Cell
- Mammalian Cell
- Sf21 Insect Cell
- Sf9 Insect Cell
- Wheat Germ
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- C
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- EP300 Related Articles
- EP300 Related Research Area
EP300 involved in several pathways and played different roles in them. We selected most pathways EP300 participated on our site, such as cAMP signaling pathway, HIF- signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EP300 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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cAMP signaling pathway | MAPK3;AMH;PDE4C;GNAI3;AKT1;ATP2B4;PIK3R5;BAD;RHOA |
HIF- signaling pathway | LTBR;TFRC;PDHA1;INSR;EIF4E1B;MTOR;Trf;PGK1;INS2 |
FoxO signaling pathway | AGAP2;FOXO4;IGF1RB;AKT2;BNIP3;CDKN1BB;GADD45AB;BCL6A;IKBKB |
Cell cycle | MAD1L1;PTTG1;YWHAG;NSL1;MIS18A;CDC26;TUBGCP5;ORC1L;CDC23 |
Wnt signaling pathway | MAPK8A;FZD2;WNT5A;ROCK2;PPP3R1;WNT7B;SKP1;RAC1;RAC3 |
Notch signaling pathway | TLE3A;CIR1;TUBB3;DLA;PSEN2;DLL4;MARK2;MFNG;DLL1 |
TGF-beta signaling pathway | BMP2B;SMAD7B;PPP2R1A;BMP7;BMPR2;BMP7B;NBL1;ID1;MAPK1 |
Adherens junction | PTPRM;ERBB2;TCF7;RAC1A;CDC42;PVRL1B;CTNNB1;SRC;RAC3A |
Jak-STAT signaling pathway | IL6R;STAT6;IL9R;IL5;GM13305;CSH1;IL7;GM-CSF;TSLP |
Long-term potentiation | CAMK2D;ITPR1;RPS6KA6;MAP2K2;RAP1B;MAP2K1;PPP3R2;MAPK3;CALM3 |
Melanogenesis | CREB3L3L;GNAI2;GNA15.4;EDNRBA;WNT8B;CAMK2D2;KITLGB;MITFB;WNT16 |
Thyroid hormone signaling pathway | RHEB;THRB;AKT1;PLCD4;MED13L;CASP9;PFKFB2;SLC16A2;PIK3R2 |
Huntingtons disease | COX4I1;ATP5D;PPIF;COX6B2;COX7B2;NDUFS3;PPARG;NDUFB1;POLR2J2 |
Tuberculosis | EEA1;IL18;RIPK2;IFNA1;HLA-DMB;ATP6V0D2;FCER1G;BAX;BID |
Hepatitis B | PIK3CB;MYD88;IL6;Fasl;MAP3K1;PIK3R1;IFNA6;GRB2;Ifna11 |
Influenza A | IFIH1;HSPA6;IRF3;PIK3R5;MAPK13;IFNB1;TLR4;PIK3CG;NFKBIA |
HTLV-I infection | Adcy4;TP53INP1;TNFRSF13C;WNT4;CANX;NFATC4;IL2RA;NFKB1;ITGB2L |
Herpes simplex infection | TNFRSF1A;SRSF2;TAF3;HLA-DRB5;EP300;Ifna15;TNFB;LTA;TAF4B |
Epstein-Barr virus infection | TP53;SNW1;TRAF3;YWHAG;POLR2J3;POLR3C;MAPK9;NFKBIE;CCNA2 |
Pathways in cancer | PRKACG;MMP9;GNGT1;DAPK1;NKX3;PIK3CB;CCNE1;PGF;STK4 |
Viral carcinogenesis | RB1;GTF2A2;CCND1;HIST1H2BQ;DDX3X;HIST1H2BF;NFKB2;TRAF2;REL |
MicroRNAs in cancer | NOTCH4;PRKCG;PRKCB;ERBB2;STMN1;TRP63;BMPR2;VIM;TP63 |
Renal cell carcinoma | PTPN11;NRAS;EGLN1;PIK3CA;PAK2;GAB1;MAPK1;HIF1A;PAK1 |
Prostate cancer | PIK3CG;FOXO1;BCL2;SOS1;FGFR2;PIK3CA;SMARCC2;ARID1A;NRAS |
EP300 has several biochemical functions, for example, DNA binding, NF-kappaB binding, RNA polymerase II activating transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EP300 itself. We selected most functions EP300 had, and list some proteins which have the same functions with EP300. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | MCM2;MEIS4.1A;OASL;HOMEZ;POLDIP2;JRK;TAF1D;MAFBA;LCOR |
NF-kappaB binding | BCL10;NPM1;MTDH;FOXP3;TAF4B;HDAC3;ANXA4;SNAI1A;ANKRD42 |
RNA polymerase II activating transcription factor binding | ZFPM1;TBX6;RB1;NHLH2;DUSP26;TBX20;EP300;NFE2L2;IFI27 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding | FUBP3;SP1;ALS2CR8;CREB3;SIX5;SMAD4;ESRRA;ZNF331;PHOX2B |
RNA polymerase II core promoter sequence-specific DNA binding | PAX8;H3F3A;GATA6;NFIL3;WBP2;H2AFY;NR4A2;GATA3;RREB1 |
SMAD binding | EP300;SOD3;COL5A2;TCF12;FLNA;SKOR1;ACVR1B;MEF2A;SKI |
acetyltransferase activity | MBOAT1;LPCAT3;NAT14;CML2;Nat3;AANAT2;KAT2B;EP300;HHAT |
activating transcription factor binding | HDAC7;RELA;DGKQ;ATOH8;MEF2D;MEF2C;PPARG;HDAC4;PSIP1 |
androgen receptor binding | RAN;NRIP1;DDX5;KDM1A;KDM4C;GRIP1;WIPI1;CALR;CCNE1 |
bHLH transcription factor binding | TCF3A;SOX9;RUNX2;PSMD9;TCF3;ISL1;BHLHE40;SP1;IKZF4 |
beta-catenin binding | MED12;CDH24;BCL9;SOX9;TCF7L2;TAX1BP3;LEF1;CD2AP;NF2 |
chromatin DNA binding | HIST1H1A;GRHL2;GRHL1;MYOD1;VAX2;EP300;RUVBL2;PRDM14;SLAMF7 |
chromatin binding | CITED2;CRTC2;JUN;L3MBTL1;GATA5;MNT;SMARCD1;STAG2;HESX1 |
core promoter binding | KLF4;RB1;RELB;KDM3A;E2F2;INSM1B;AGO1;MYBBP1A;SFPI1 |
damaged DNA binding | CRY-DASH;CRY2;TRPC2;POLI;NEIL3;POLD1;RAD52;PNKP;APTX |
glucocorticoid receptor binding | EP300;YWHAH;GRIP1;NR4A2;STAT3;STAT5B;NRIP1;FKBP4;CEBPB |
histone acetyltransferase activity | KAT7;TAF1L;ATF2;CREBBP;CLOCK;EP300;KAT7A;KAT6A;CDYL |
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor | NAT8;RHBDL1;KAT2B;ESCO2;EP300;CEACAM21;NAT8B |
mitogen-activated protein kinase binding | ATF7;CDK5RAP3;MAPKAPK2B;SIRT1;TNIP1;GTF2I;TPR;MAPK7;PTPRJ |
nuclear hormone receptor binding | CRX;NRIP1;EP300;CRY1;HIF1A;NCOA2;NCOA3;TACC2;TCF7L2 |
p53 binding | ANKRD1;RCHY1;MDM2;TRIM24;TP73;PTTG1IP;GSK3B;BCL2L12;HTT |
peroxisome proliferator activated receptor binding | EP300;NR0B2;NFATC4;ASXL2;HMGA1;ASXL1;PRMT2;MED1;HMGA1-RS1 |
pre-mRNA intronic binding | RBM4;RNPC3;EP300;SOX9;PRPF8;HNRNPA2B1;RBM41 |
protein C-terminus binding | SP1;ARL6IP5;LCK;BAIAP2;DDX1;SREBF2;VPS4A;CORO1A;KSR1 |
protein antigen binding | EP300;ITGA4;KLRC2;KLRD1;H2-AB1 |
protein binding | ITGA3;YWHAZ;PIKFYVE;FAM53C;ALKBH6;HIST1H3A;AP1G1;MYBBP1A;DPM1 |
protein complex binding | MTHFR;CRHR1;KAT2B;TXN2;STK11;NFKBIA;TMED10;BAX;KRT8 |
transcription coactivator activity | MED27;MAML1;CCNE1;MAML2;HAND1;TADA2A;MED26;ABRA;CCAR1 |
contributes_to transcription coactivator activity | EP300;PHF2;CREBBP;ARID5B |
transcription factor binding | NLRP3;RNF222;PARK7;GTF2B;SORBS3;STK36;ARNT;TCF7L2;AIP |
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | MAF;ZGLP1;BARHL1B;EP300;ATF5;FOXO3;PKNOX1;RAD21;SRF |
transferase activity, transferring acyl groups | ACAA1A;GGT7;NAT15;CDYL;Nat3;LYCAT;MBOAT7;ZDHHC24;GGACT.1 |
zinc ion binding | APOBEC3F;UBR2;ASTL;RNF139;SIAH2L;RTN4IP1;NR4A2B;ANPEPA;ZMIZ1A |
EP300 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EP300 here. Most of them are supplied by our site. Hope this information will be useful for your research of EP300.
HIF1A; TP53
- Q&As
- Reviews
Q&As (5)
Ask a questionEP300 is crucial for embryonic development, and mutations in the EP300 gene can lead to developmental abnormalities. Understanding its role is essential for potential interventions.
EP300 is involved in neuronal function and survival. Dysregulation of EP300 has been observed in neurodegenerative diseases like Alzheimer's and Parkinson's.
Research is underway to explore drugs that modulate EP300 activity for potential therapeutic interventions in neurodegenerative disorders, but clinical applications are still in the early stages.
Yes, there are clinical trials exploring the therapeutic potential of targeting EP300 in various cancer types, focusing on its role in controlling cell proliferation and survival.
While there are no specific drugs targeting EP300 approved for cardiovascular diseases, ongoing research aims to identify compounds that can modulate its activity for therapeutic purposes.
Customer Reviews (3)
Write a reviewIt has consistently demonstrated outstanding results, consistently producing clear and sharp bands, allowing for accurate and reliable protein detection and quantification.
Its stability and purity make it an ideal candidate for studying protein structures at a high resolution, providing crucial insights into the organization and function of the EP300 protein.
I highly recommend the EP300 protein for its exceptional performance in Western blot analysis.
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