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EPB49

Official Full Name

erythrocyte membrane protein band 4.9 (dematin)
Overview

Dematin, or EPB49, is an actin-bundling protein originally identified in the erythroid membrane skeleton. Its;actin-bundling activity is abolished upon phosphorylation by cAMP-dependent protein kinase and is restored after;dephosphorylation (Rana et al., 1993 (PubMed 8341682)).
Synonyms

EPB49; erythrocyte membrane protein band 4.9 (dematin); dematin; DMT; FLJ78462; FLJ98848;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	EPB49-12480H	Recombinant Human EPB49, His-tagged	E.coli	His	1-405a.a.	$319 / 25ug
Human	EPB49-3363H	Recombinant Human EPB49 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	EPB49-565HCL	Recombinant Human EPB49 cell lysate		N/A		Inquiry
Human	EPB49-4274HF	Recombinant Full Length Human EPB49 Protein, GST-tagged	In Vitro Cell Free System	GST	383 amino acids	Inquiry
Human	EPB49-1429H	Recombinant Human EPB49 Protein, His-tagged	E.coli	N-His	Met1-Ser269	Inquiry

Involved Pathway
Protein Function
Interacting Protein
EPB49 Related Articles

EPB49 involved in several pathways and played different roles in them. We selected most pathways EPB49 participated on our site, such as Miscellaneous transport and binding events, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPB49 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Miscellaneous transport and binding events	MAGT1;DMTN;ADD2;MRS2;PIP;ADD3B;ANKH;NIPA1;NIPAL3
Transmembrane transport of small molecules	SLC9A6A;SLC4A1B;SLC44A5B;SLC26A3.2;SLC28A3;TTYH1;TRPA1B;RHCG2A;MMGT1

EPB49 has several biochemical functions, for example, actin binding, protein binding, protein self-association. Some of the functions are cooperated with other proteins, some of the functions could acted by EPB49 itself. We selected most functions EPB49 had, and list some proteins which have the same functions with EPB49. You can find most of the proteins on our site.

Function	Related Protein
actin binding	EZR;WAS;CAPZA1;TAGLN;MYBPC3;CNN3B;FER;FSCN2A;ANLN
protein binding	DHX40;TMEM185A;SEC61B;LILRB3;CD1d1;SDHA;COA6;NHEJ1;SIRPG
protein self-association	BCL10;TRP53;SVIP;NKX3;TTN;ADAM8;ZKSCAN17;ZSWIM2;S100A7A
receptor binding	CD200;F2RL1;C5;RSPO1;ANGPTL2;ABL2;TYROBP;POMC;CCL17
spectrin binding	EPB41;USH1C;SPTAN1;CAMSAP1L1;DYNC1I1;MYO7A;ANK1;MYO10;GBP1

EPB49 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPB49 here. Most of them are supplied by our site. Hope this information will be useful for your research of EPB49.

GOLGA2; saicar; PKM; DYNC1LI2; SNRPD2; PTOV1; PROCR; YWHAB

Chen, L; Brown, JW; et al. The Allosteric Mechanism Induced by Protein Kinase A (PKA) Phosphorylation of Dematin (Band 4.9). JOURNAL OF BIOLOGICAL CHEMISTRY 288:8313-8320(2013).

Nikolovski, Z; De La Torre, C; et al. Alterations of the erythrocyte membrane proteome and cytoskeleton network during storage - a possible tool to identify autologous blood transfusion. DRUG TESTING AND ANALYSIS 4:882-890(2012).