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EPM2A

Official Full Name

epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
Overview

This gene encodes a dual-specificity phosphatase that associates with polyribosomes. The encoded protein may be involved in the regulation of glycogen metabolism. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. Alternative splicing results in multiple transcript variants.
Synonyms

EPM2A; epilepsy, progressive myoclonus type 2A, Lafora disease (laforin); epilepsy, progressive myoclonus type 2, Lafora disease (laforin); laforin; LD; LDE; LAFPTPase; lafora PTPase; EPM2; MELF;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	EPM2A-3411H	Recombinant Human EPM2A Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	EPM2A-568HCL	Recombinant Human EPM2A cell lysate		N/A		Inquiry
Human	EPM2A-4388HF	Recombinant Full Length Human EPM2A Protein, GST-tagged	In Vitro Cell Free System	GST	331 amino acids	Inquiry
Mouse	EPM2A-5255M	Recombinant Mouse EPM2A Protein	Mammalian Cell	His		Inquiry
Mouse	EPM2A-2821M-B	Recombinant Mouse EPM2A Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	EPM2A-2821M	Recombinant Mouse EPM2A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Chicken	EPM2A-2748C	Recombinant Chicken EPM2A	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
EPM2A Related Research Area

EPM2A involved in several pathways and played different roles in them. We selected most pathways EPM2A participated on our site, such as Disease, Diseases of carbohydrate metabolism, Diseases of metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPM2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Disease	RBP1;EPM2A;CHMP4C;OPN1LW;TNKS2;TCEB3;HMGA1;CPSF4;AP2A2
Diseases of carbohydrate metabolism	GYG1;GYG2;EPM2A
Diseases of metabolism	FDX1L;CYP11A1;MTRR;AMN;SFTPC;SFTPB;FDXR;MMADHC;GYG1
Glucose metabolism	SLC25A1;GYG2;GYG1B;AGL;PYGMB;SLC25A11;NHLRC1;GYG1A;SLC25A13
Glycogen storage diseases
Glycogen synthesis	EPM2A;NHLRC1;GYG1B;GYG1A
Metabolism	UGT1B2;PTGDSA;SLC25A27;NAT2;ETFB;MOCOS;CPNE3;BHMT2;ADSSL1
Metabolism of carbohydrates	SLC5A9;GLB1L;SLC5A2;HS3ST4;GYG1A;KIAA1199;HAS1;CHST14;GYG1B

EPM2A has several biochemical functions, for example, carbohydrate phosphatase activity, phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPM2A itself. We selected most functions EPM2A had, and list some proteins which have the same functions with EPM2A. You can find most of the proteins on our site.

Function	Related Protein
carbohydrate phosphatase activity
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	EPM2A;PTPMT1;INPP5E;OCRL;SYNJ2;INPP5B
protein binding	ZMYM4;ERP27;SPSB1;MLST8;SCARF1;SEMA6A;APOE;UBE2K;CDK5
protein serine/threonine phosphatase activity	PPEF1;PPM1LB;CDKN3;PPP1R3C;CDC14B;CDC14A;PPM1J;PPP3CA;PPM1L
protein tyrosine phosphatase activity	RNGTT;MTMR2;PTPN4B;DUSP26;DUSP22A;PTPN11A;EYA3;EVLA;DUSP6
protein tyrosine/serine/threonine phosphatase activity	DUSP15;SSH1;PTPDC1;DUSP26;CDC14A;TENC1;CDC14AB;PTP4A2B;DUSP4
starch binding	STBD1;GPCPD1;EPM2A

EPM2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPM2A here. Most of them are supplied by our site. Hope this information will be useful for your research of EPM2A.

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