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EPOR

  • Official Full Name

    Erythropoietin Receptor

  • Overview

    This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.
  • Synonyms

    EPOR; erythropoietin receptor; EPO-R; MGC138358;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Dog
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • Human
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Rabbit
  • Wheat Germ
  • Fc
  • Fc|His
  • GST
  • hFc
  • His
  • His (Fc)
  • Avi
  • His|GST
  • GB1
  • SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EPOR-29H Active Recombinant Human EPOR Protein, Fc-tagged HEK293 Fc Ala 25 - Cys 241
Human EPOR-27012TH Recombinant Human EPOR, Fc-tagged Fc
Human EPOR-599H Recombinant Human EPOR protein, His & GST-tagged E.coli His/GST Pro33~Leu210 (Accession # P19235)
Human EPOR-28H Recombinant Human EPOR, Fc tagged Human Cell Fc
Human EPOR-3424H Recombinant Human EPOR Protein, GST-tagged Wheat Germ GST
Human EPOR-3851H Recombinant Human EPOR, His tagged Human Cell His
Human EPOR-4114H Recombinant Human Etythropoietin Receptor, Fc-tagged Human Fc
Human EPOR-598H Recombinant Human EPOR protein, His & GST-tagged E.coli His/GST Arg276~Ala496 (Accession # P19235)
Human EPOR-194H Recombinant Human EPOR protein, His-tagged Insect Cell His
Human EPOR & CD131-1943HCL Recombinant Human EPOR & CD131 cell lysate Human Cell N/A
Human EPOR-2055HCL Recombinant Human EPOR cell lysate Human Cell N/A
Human EPOR-2296H Recombinant Human EPOR Protein (Ala25-Pro250), N-His tagged E.coli N-His Ala25-Pro250
Human EPOR-2045H Recombinant Human EPOR Protein, Fc/His-tagged HEK293 Fc/His Ala25-Pro250
Human CAB11532RH Rabbit Anti-Human Erythropoietin Receptor Monoclonal Antibody Rabbit N/A
Human EPOR-1434H Recombinant Human EPOR Protein, His-tagged E.coli N-His Pro33-Leu210
Human EPOR-4403HF Recombinant Full Length Human EPOR Protein, GST-tagged In Vitro Cell Free System GST 508 amino acids
Human EPOR-241H Recombinant Human EPOR Protein, Fc-tagged HEK293 Fc 508
Human EPOR-2642H Active Recombinant Human EPOR protein, hFc&His-tagged HEK293 hFc&His Ala25-Pro250
Human EPOR-0237H Recombinant Human EPOR protein, His-tagged, Biotinylated HEK293 His Met1-Pro250
Mouse Epor-464M Active Recombinant Mouse Erythropoietin Receptor Mammalian cells N/A
Mouse Epor-461M Active Recombinant Mouse Erythropoietin Receptor, Fc-tagged Mammalian cells Fc
Mouse Epor-499M Recombinant Mouse Epor, Fc-tagged Insect Cell Fc Met1-Pro249
Mouse Epor-212M Recombinant Mouse Epor, Fc-His tagged Human Cell Fc/His
Mouse Epor-2290M Active Recombinant Mouse Epor protein, His-tagged HEK293 His Met1-Pro249
Mouse Epor-600M Recombinant Mouse Epor protein, His-tagged E.coli His Arg45~Ala244 (Accession # P14753)
Mouse EPOR-2582MCL Recombinant Mouse EPOR cell lysate Human Cell N/A
Mouse Epor-42M Recombinant Mouse Epor Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Epor-1445M Recombinant Mouse Epor protein, His-tagged Insect Cell His 25-249aa
Mouse Epor-42M-B Recombinant Mouse Epor Protein Pre-coupled Magnetic Beads HEK293
Rat Epor-601R Recombinant Rat Epor protein, His-tagged E.coli His Leu314~Tyr467 (Accession # Q07303)
Rat Epor-4240R Recombinant Rat Epor protein, His-SUMO&His-tagged E.coli His-SUMO&His 25-249aa
Rat Epor-1100R Recombinant Rat Epor protein, His-GB1&His-tagged E.coli His-GB1&His 25-249aa
Rat Epor-2864R Recombinant Rat Epor protein, His-tagged E.coli His 25-249aa
Dog EPOR-2863D Recombinant Dog EPOR protein, His-tagged E.coli His 25-250aa
Dog EPOR-1073D Recombinant Dog EPOR protein, His-GB1&His-tagged E.coli His-GB1&His 25-250aa
Homo sapiens (Human) RFL1278HF Recombinant Full Length Human Erythropoietin Receptor(Epor) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (25-508)
Mus musculus (Mouse) RFL20198MF Recombinant Full Length Mouse Erythropoietin Receptor(Epor) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (25-507)
Zebrafish EPOR-3852Z Recombinant Zebrafish EPOR Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EPOR Related Articles
  • EPOR Related Research Area
  • EPOR Related Signal Pathway

EPOR involved in several pathways and played different roles in them. We selected most pathways EPOR participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPOR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionPF4V1;CTF1;PDGFAA;CXCR6;Ifna11;FLT4;IL6ST;Pdgfa&Pdgfb;CXCR2
PIK-Akt signaling pathwayAKT2;GH1;FGF4;MAP2K2;BCL2L1;TEK;IFNA16;FOXO3;PPP2R5A
Jak-STAT signaling pathwayPRL;SOCS3B;STAT1B;IL17D;IL10RB;Il23a; Il12b;NT5C3;SOCS5;STAT4
Hematopoietic cell lineageIL11RA;IL3RA;CR1;IL6;CD1C;FLT3LG;CD22;IL7;FCGR1A

EPOR has several biochemical functions, for example, erythropoietin receptor activity, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPOR itself. We selected most functions EPOR had, and list some proteins which have the same functions with EPOR. You can find most of the proteins on our site.

Function Related Protein
erythropoietin receptor activity
identical protein bindingAMOTL2;DYNLT3;HSPB8;ACY3;IAPP;PNMA5;SUN2;ADIPOQ;TRIM21
protein bindingRICTOR;VAV1;FUBP1;CYBRD1;GABBR1;THBS4;ZNF274;CXorf41;RFX1

EPOR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPOR here. Most of them are supplied by our site. Hope this information will be useful for your research of EPOR.

PTPN6; PTPN1; Cish; INPP5D

Maxwell, P; Melendez-Rodriguez, F; et al. Novel antibodies directed against the human erythropoietin receptor: creating a basis for clinical implementation. BRITISH JOURNAL OF HAEMATOLOGY 168:429-442(2015).
Fujimi, A; Kamihara, Y; et al. Anti-erythropoietin receptor antibody-associated pure red cell aplasia accompanied by Coombs-negative autoimmune hemolytic anemia in a patient with T cell/histiocyte-rich large B cell lymphoma. INTERNATIONAL JOURNAL OF HEMATOLOGY 100:490-493(2014).
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