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EPRS

Official Full Name

glutamyl-prolyl-tRNA synthetase
Overview

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined.
Synonyms

EPRS; glutamyl-prolyl-tRNA synthetase; QARS, QPRS; bifunctional glutamate/proline--tRNA ligase; EARS; GLUPRORS; glutamate tRNA ligase; PARS; proline tRNA ligase; proline-tRNA ligase; prolyl-tRNA synthetase; glutaminyl-tRNA synthetase; proliferation-induci;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
His|T7
Myc
DDK
MYC

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	EPRS-8223H	Recombinant Human EPRS protein, His & T7-tagged	E.coli	His/T7	Asp749~Thr956 (Accession # P07814)	Inquiry
Human	EPRS-12504H	Recombinant Human EPRS, GST-tagged	E.coli	GST	C-term-350a.a.	$319 / 25ug
Human	EPRS-2208H	Recombinant Human EPRS Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	EPRS-3461H	Recombinant Human EPRS protein, His-tagged	E.coli	His	1163-1512 aa	$319 / 25ug
Mouse	EPRS-5264M	Recombinant Mouse EPRS Protein	Mammalian Cell	His		Inquiry
Mouse	Eprs-8224M	Recombinant Mouse Eprs protein, His & T7-tagged	E.coli	His/T7	Gly1007~Tyr1512 (Accession # Q8CGC7)	Inquiry
Mouse	Eprs-331M	Recombinant Mouse Eprs Protein, MYC/DDK-tagged	HEK293T	MYC/DDK		Inquiry
Mouse	EPRS-2826M	Recombinant Mouse EPRS Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	EPRS-2826M-B	Recombinant Mouse EPRS Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	EPRS-8402Z	Recombinant Zebrafish EPRS	Mammalian Cell	His		Inquiry
Chicken	EPRS-1540C	Recombinant Chicken EPRS	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
EPRS Related Articles

EPRS involved in several pathways and played different roles in them. We selected most pathways EPRS participated on our site, such as Porphyrin and chlorophyll metabolism, Aminoacyl-tRNA biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPRS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Porphyrin and chlorophyll metabolism	HCCSB;HCCSA.1;BLVRB;UGT1A7;UROS;UGT2B15;ALAS1;CP;COX10
Aminoacyl-tRNA biosynthesis	VARS2;LARS2;SARS2;KARS;TARS;PET112L;AARS;RARS;MTFMT
Metabolic pathways	MAN2A1;CYP4F2;INPP5J;COX15;PLA2G2A;FBP1;GPAM;MIBP2;SPTLC1

EPRS has several biochemical functions, for example, ATP binding, GTPase binding, RNA stem-loop binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPRS itself. We selected most functions EPRS had, and list some proteins which have the same functions with EPRS. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	CDK12;STK19;UBE2QL1;RIPK3;GRK7B;SLC27A2;CDC34A;KIF7;MYH6
GTPase binding	MARCH5;HSP90AA1;GM5506;BNIP3;LCP1;ENO1;GNB3;STOML2;RAB3D
RNA stem-loop binding	DDX3X;EPRS;CPEB3;DAZAP1
glutamate-tRNA ligase activity	EPRS;EARS2
proline-tRNA ligase activity	EPRS;PARS2
protein binding	CSDE1;HIST1H3D;DKK1B;SRSF5;TSGA10;PLXNB2;GRM2;CCAR1;MEI4

EPRS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPRS here. Most of them are supplied by our site. Hope this information will be useful for your research of EPRS.

IARS; HSP90AA1; gag; NFKBIE; IKBKB; MAP3K7; SYNCRIP; ATG12; ETS1; TFE3; MCC; EEF1D

Shin, C; Hwang, GS; et al. H-1, C-13 and N-15 resonance assignment of WHEP domains of human glutamyl-prolyl tRNA synthetase. BIOMOLECULAR NMR ASSIGNMENTS 9:25-30(2015).

Saga, K; Hasegawa, F; et al. Comparative evaluation of wet and dry processes for recovering hydrocarbon from Botryococcus Braunii. APPLIED ENERGY 141:90-95(2015).