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EPX

  • Official Full Name

    eosinophil peroxidase

  • Overview

    This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded precursor protein is processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a cluster of three peroxidase genes at chromosome 17q23. Mutations in this gene result in eosinophil peroxidase deficiency.
  • Synonyms

    EPX; eosinophil peroxidase; EPO; EPP; EPX PEN; Eosinophil peroxidase [Precursor]; EPER; PERE; EPX-PEN;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • CHO
  • E. coli
  • HEK293
  • Human Eosinophils
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EPX-3434H Recombinant Human EPX Protein, GST-tagged Wheat Germ GST
Human EPX-6573HCL Recombinant Human EPX 293 Cell Lysate HEK293 N/A
Human EPX-1862H Native Human Eosinophil Peroxidase Human Eosinophils N/A
Human EPX-4416HF Recombinant Full Length Human EPX Protein, GST-tagged In Vitro Cell Free System GST 715 amino acids
Human EPX-8107H Native Human Eosinophil Peroxidase Human Eosinophils N/A
Human EPX-51H Recombinant Human EPX Protein, His-tagged E. coli His Arg140~Gly250
Mouse EPX-5272M Recombinant Mouse EPX Protein Mammalian Cell His
Mouse EPX-2834M-B Recombinant Mouse EPX Protein Pre-coupled Magnetic Beads HEK293
Mouse Epx-905M Recombinant Mouse Epx Protein, His-tagged CHO N-His Gln19-Arg300
Mouse EPX-2834M Recombinant Mouse EPX Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse EPX-5257M Recombinant Mouse EPX Protein, His-GST-tagged E. coli His-GST Gln19~Arg300
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EPX Related Articles

EPX involved in several pathways and played different roles in them. We selected most pathways EPX participated on our site, such as Asthma, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AsthmaHLA-DRB1;MS4A2;FCER1A;EPX;HLA-DQA1;CD40LG;HLA-DRB5;IL4;HLA-DRB3

EPX has several biochemical functions, for example, heme binding, metal ion binding, peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EPX itself. We selected most functions EPX had, and list some proteins which have the same functions with EPX. You can find most of the proteins on our site.

Function Related Protein
heme bindingCYP51;NGB;ABCB6;CYP4T8;Adgb;CYP8B3;HBE;CYP11B2;CYP2D10
metal ion bindingZDHHC18A;TRMT1;ZMYND19;CYP2K16;MORC1;ZNF563;POMT2;ALOX5A;ZSCAN4C
peroxidase activityGPX1B;GPX8;GPX4B;MPX;PXDN;GPX7;GPX5;MGST3;GPX1A

EPX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPX here. Most of them are supplied by our site. Hope this information will be useful for your research of EPX.

NCK1; PLCG1; PIK3R1

Ochkur, SI; Kim, JD; et al. A sensitive high throughput ELISA for human eosinophil peroxidase: A specific assay to quantify eosinophil degranulation from patient-derived sources. JOURNAL OF IMMUNOLOGICAL METHODS 384:10-20(2012).
Ochkur, SI; Kim, JD; et al. The development of a sensitive and specific ELISA for mouse eosinophil peroxidase: Assessment of eosinophil degranulation ex vivo and in models of human disease. JOURNAL OF IMMUNOLOGICAL METHODS 375:138-147(2012).
  • Q&As
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