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ERCC4

Official Full Name

excision repair cross-complementing rodent repair deficiency, complementation group 4
Overview

The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5 incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).
Synonyms

ERCC4; excision repair cross-complementing rodent repair deficiency, complementation group 4; XPF; DNA repair endonuclease XPF; RAD1; xeroderma pigmentosum; complementation group F; DNA excision repair protein ERCC-4; DNA repair protein complementing XP-F;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Mammalian cells

Tag

Flag
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ERCC4-6564HCL	Recombinant Human ERCC4 293 Cell Lysate	HEK293	N/A		Inquiry
Human	ERCC4-5573H	Recombinant Human ERCC4 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	ERCC4-3826H	Recombinant Human ERCC4 protein, His-tagged	E.coli	His	658-753 aa	$319 / 25ug
Human	ERCC4-861H-B	Recombinant Human ERCC4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	ERCC4-1928HFL	Recombinant Full Length Human ERCC4 Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	ERCC4-861H	Recombinant Human ERCC4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Ercc4-2853M	Recombinant Mouse Ercc4 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	ERCC4-10173Z	Recombinant Zebrafish ERCC4	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
ERCC4 Related Research Area

ERCC4 involved in several pathways and played different roles in them. We selected most pathways ERCC4 participated on our site, such as Nucleotide excision repair, Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Nucleotide excision repair	INO80C;GTF2H3;POLE2;GTF2H2C;BIVM-ERCC5;ERCC2;XPA;NFRKB;MNAT1
Fanconi anemia pathway	REV3L;FANCM;POLK;RPA1;BRCA1;RMI2;C19orf40;CDK5R2;RPA3

ERCC4 has several biochemical functions, for example, TFIID-class transcription factor binding, damaged DNA binding, endodeoxyribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC4 itself. We selected most functions ERCC4 had, and list some proteins which have the same functions with ERCC4. You can find most of the proteins on our site.

Function	Related Protein
TFIID-class transcription factor binding	ERCC4;NOP58;ERCC1;FBL;ZNHIT6
damaged DNA binding	MGMT;RPA2;RPS3;POLH;POLB;UNG;RBBP8;ERCC1;XRCC5
endodeoxyribonuclease activity	ZRANB3;MBD4;MRE11A;RPS3;DNASE1;ERCC4;ERCC5;APEX1;DNASE1L3
contributes_to endodeoxyribonuclease activity	XRCC2;RAD51B;RAD51L3;RAD51L1;DMC1;ERCC4;RAD51D;RAD51
protein C-terminus binding	KCNK3;MIF4GD;EFHC1;STIP1;SNX17;SREBF2;PHB2;KCNIP3;PLEKHB1
protein N-terminus binding	ACTN4;TSC1;NCOA1;MAP2K1;MORF4L1;EXOC4;ERCC4;HAX1;TARBP2
protein binding	SPZ1;DSN1;FAM110A;MTERF;CYS1;RPL15;GTF2E1;ANKRD45;SMARCA2
single-stranded DNA binding	FBXO18;PCBP1;WBP11;TTC6;HMGB1;RAD23A;LUZP4;RBMS1;CNBP
single-stranded DNA endodeoxyribonuclease activity	ERCC4;DCLRE1C;RBBP8;MRE11A;SETMAR
contributes_to structure-specific DNA binding	ERCC4;ERCC1

ERCC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC4.

SLX4; SLX1A; ERCC1

Nucleotide Excision Repair/Transcription Coupled Repair