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ERCC6L

  • Official Full Name

    excision repair cross-complementing rodent repair deficiency, complementation group 6-like

  • Overview

    Plk1-interacting checkpoint helicase (PICH ) is an essential component of the spindle assembly checkpoint (Baumann, C., et al. (2007). Cell 128:101–114). This protein is an ATPase family SNF2 member, and serves as a binding partner and substrate for Plk1. When PICH is phosphorylated, it retrieves Plk1 which serves to mediate the localization of PICH. As a DNA helicase, PICH gathers at kinetochores and centromeres during prometaphase, acting as a necessary part of the spindle assembly checkpoint by recruiting MAD2 and mediating chromatin centromeric tension. Depleted PICH results in the cancellation of the spindle checkpoint causing large scale missegregation of the chromosome.
  • Synonyms

    ERCC6L; excision repair cross-complementing rodent repair deficiency, complementation group 6-like; DNA excision repair protein ERCC-6-like; FLJ20105; PICH; PLK1 interacting checkpoint helicase; tumor antigen BJ-HCC-15; SNF2/RAD54 family protein; ATP-dependent helicase ERCC6-like; excision repair protein ERCC6-like; Plk1-interacting checkpoint helicase; excision repair cross-complementing rodent repair deficiency complementation group 6 - like; MGC131695;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ERCC6L-3462H Recombinant Human ERCC6L Protein, GST-tagged Wheat Germ GST
Human ERCC6L-634HCL Recombinant Human ERCC6L cell lysate N/A
Human ERCC6L-4562HF Recombinant Full Length Human ERCC6L Protein, GST-tagged In Vitro Cell Free System GST 419 amino acids
Mouse ERCC6L-5290M Recombinant Mouse ERCC6L Protein Mammalian Cell His
Mouse ERCC6L-2844M Recombinant Mouse ERCC6L Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ERCC6L-2844M-B Recombinant Mouse ERCC6L Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ERCC6L-5868Z Recombinant Zebrafish ERCC6L Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ERCC6L involved in several pathways and played different roles in them. We selected most pathways ERCC6L participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, M Phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC6L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell CycleCDT1;NUP35;NUPL2;MDM2;NEK9;CTDNEP1A;SPDL1;SKP1;YWHAQ
Cell Cycle, MitoticCETN2;VRK2;TMPO;GMNN;CDK4;NCAPG2;SPDL1;CSNK1D;CDK5RAP2
M PhasePMF1;PDS5B;SET;TMEM188;MASTL;SKA2;MCPH1;ZWINT;CTDNEP1A
Mitotic AnaphaseNSL1;SPC24;ANKLE2;INCENP;SKA1;CENPI;NDC80;ITGB3BP;RCC2
Mitotic Metaphase and AnaphaseCENPH;VRK1;CENPC1;SPDL1;CENPL;SGOL2;B9D2;MLF1IP;ERCC6L
Mitotic PrometaphaseCENPP;SMC4;CENPN;PDS5A;CENPC1;RCC2;SPC25;CDCA5;NUF2
PLK1 signaling eventsBORA;ECT2;TCTN2;SPC24;TPX2;PLK1S1;ERCC6L;NDC80;TPT1
RHO GTPase EffectorsSPDL1;CDCA8;NF2A;MKL1;ABI1A;NCKAP1;ROPN1;WIPF3;MIS12

ERCC6L has several biochemical functions, for example, ATP binding, DNA binding, helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC6L itself. We selected most functions ERCC6L had, and list some proteins which have the same functions with ERCC6L. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCHKB;MYHZ1.1;KIF16B;PRPS2;MYO1G;ACTA1;NIM1;TNIKA;MKNK2
DNA bindingMLXIPL;RARGA;HOXC4A;ZNF12;ETV5B;ZFP513;ZNF76;MIER2;INSM1B
helicase activitySHPRH;DHX57;EIF4A1;SMARCAL1;EIF4A1A;ATRX;GTF2F2;DHX34;WRN
protein bindingGRM6;SPG11;OAS1A;CBY1;TACC1;SIRT7;POT1A;DYNLL1;RPS25

ERCC6L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC6L here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC6L.

LMO4; PLK1; HTT; RPA3; Plk1; Ercc6l; RB1CC1; ZDHHC17; LDHA; EIF4B; BLM; TOP3A; CDC5L; RMI1

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