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ERCC8

Official Full Name

excision repair cross-complementing rodent repair deficiency, complementation group 8
Overview

This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
Synonyms

ERCC8; excision repair cross-complementing rodent repair deficiency, complementation group 8; CKN1, Cockayne syndrome 1 (classical); DNA excision repair protein ERCC-8; CSA; Cockayne syndrome WD-repeat protein CSA; cockayne syndrome WD repeat protein CSA;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ERCC8-26850TH	Recombinant Human ERCC8	Wheat Germ	N/A	396 amino acids	Inquiry
Human	ERCC8-3463H	Recombinant Human ERCC8 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	ERCC8-12527H	Recombinant Human ERCC8, His-tagged	E.coli	His	1-205a.a.	$319 / 25ug
Human	ERCC8-6562HCL	Recombinant Human ERCC8 293 Cell Lysate	HEK293	N/A		Inquiry
Human	ERCC8-1436H	Recombinant Human ERCC8 Protein, His&GST-tagged	E.coli	N-His&GST	Met1-Gly396	Inquiry
Human	ERCC8-160HF	Recombinant Full Length Human ERCC8 Protein	In Vitro Cell Free System		396 amino acids	Inquiry
Human	ERCC8-4563HF	Recombinant Full Length Human ERCC8 Protein, GST-tagged	In Vitro Cell Free System	GST	205 amino acids	Inquiry
Mouse	ERCC8-5291M	Recombinant Mouse ERCC8 Protein	Mammalian Cell	His		Inquiry
Mouse	ERCC8-2845M	Recombinant Mouse ERCC8 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	ERCC8-2845M-B	Recombinant Mouse ERCC8 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Ercc8-1437M	Recombinant Mouse Ercc8 Protein, His&GST-tagged	E.coli	N-His&GST	Met1-Gly397	Inquiry
Zebrafish	ERCC8-1509Z	Recombinant Zebrafish ERCC8	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

ERCC8 involved in several pathways and played different roles in them. We selected most pathways ERCC8 participated on our site, such as DNA Repair, Dual incision in TC-NER, Formation of TC-NER Pre-Incision Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
DNA Repair	UBE2V2;SMARCA5;ALKBH2;HUS1;ASCC3;PARP2;CHD1L;RAD9A;COPS7A
Dual incision in TC-NER	KIAA1530;DDB1;ZNF830;ERCC8;TCEA1;ZFP830;PPIE
Formation of TC-NER Pre-Incision Complex	PPIE;ZNF830;COPS3;GPS1;KIAA1530;COPS7B;COPS8;COPS5;COPS7A
Gap-filling DNA repair synthesis and ligation in TC-NER	TCEA1;DDB1;ERCC8;PPIE;ZFP830;ZNF830;KIAA1530
Nucleotide Excision Repair	COPS7B;ERCC2;INO80;RFC5;ERCC3;COPS4;COPS2;RPA4;RAD23A
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	COPS2;PPIE;KIAA1530;ZFP830;COPS8;COPS6;COPS7A;ZNF830;GPS1
Ubiquitin mediated proteolysis	FBXW7;MGRN1B;FLJ11011L;UBA1;CUL5;PIAS2;TCEB2;UBE1Y1;CBLB

ERCC8 has several biochemical functions, for example, NOT DNA helicase activity, NOT DNA-dependent ATPase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC8 itself. We selected most functions ERCC8 had, and list some proteins which have the same functions with ERCC8. You can find most of the proteins on our site.

Function	Related Protein
NOT DNA helicase activity	ERCC8;DNA2;ERCC6
NOT DNA-dependent ATPase activity
protein binding	MSH2;ALOX5;CXCL10;MAF;FCGR2A;NCLN;USP15;BEX1;NDUFA4
protein complex binding	GNB2;HSPD1;ADM2;SH2B3;MYO7A;UGT1A6A;VDAC1;PPFIA2;MYC
contributes_to ubiquitin-protein transferase activity	KLHL33;KBTBD3;ERCC8;KLHL2;BACH1;BACH2;KBTBD12;ANAPC11;BCOR

ERCC8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC8.

XAB2; Ddb1; COPS6; COPS5; UQCRQ; CBR1; CSNK2B; CUL4B