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ESPL1

Official Full Name

extra spindle pole bodies homolog 1
Overview

Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for;chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The;first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second;step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the;final separation of sister chromatids (Sun et al., 2009 (PubMed 19345191)).
Synonyms

ESPL1; extra spindle pole bodies homolog 1 (S. cerevisiae); extra spindle poles like 1 (S. cerevisiae); separin; ESP1; KIAA0165; SEPA; separase; caspase-like protein ESPL1; extra spindle poles like 1; extra spindle poles-like 1 protein; FLJ46492;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	ESPL1-3502H	Recombinant Human ESPL1 Protein, GST-tagged	Wheat Germ	GST	Inquiry
Mouse	ESPL1-5323M	Recombinant Mouse ESPL1 Protein	Mammalian Cell	His	Inquiry
Mouse	ESPL1-2865M	Recombinant Mouse ESPL1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	ESPL1-2865M-B	Recombinant Mouse ESPL1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein
ESPL1 Related Articles

ESPL1 involved in several pathways and played different roles in them. We selected most pathways ESPL1 participated on our site, such as Cell cycle, Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ESPL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell cycle	HJURP;MSH4;CDK11B;MAD2L2;CEP72;RAD21A;KAT5;SET;NEK6
Oocyte meiosis	CALM3B;AURKA;CALM3A;PPP2R1B;CAMK2B1;CPEB3;MAPK3;PRKACAA;PPP1R2P9

ESPL1 has several biochemical functions, for example, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ESPL1 itself. We selected most functions ESPL1 had, and list some proteins which have the same functions with ESPL1. You can find most of the proteins on our site.

Function	Related Protein
cysteine-type endopeptidase activity	ATG4B;CASP7;USP37;CASP10;CTSZ;USP15;TINAG;USP25;CASP9
cysteine-type peptidase activity	CTSSB.1;ALG13;DESI1;SENP3A;USP9;USP9X;CTS7;CAPN3A;USP12A
hydrolase activity	YDJC;KLK1B22;FAM49BA;PTPRK;FAHD2B;ABHD2B;ATP1A1A.2;ATP8B5;PNPLA7
peptidase activity	GZMF;OTUD4;TRY;AGBL1;DPEP3;Ctsl;PSMB8F;TMPRSS4A;lon

ESPL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ESPL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ESPL1.

PTTG1; CDK1; CCNB1; C1QBP; ESPL1; BDP1; KIRREL; IMP4; PML; LONP1; MECP2; VAV2; GTF2I; ZMYM4; EFTUD1; DNAAF5; MB21D1; DOT1L; MMS19

Mukherjee, M; Ge, G; et al. MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER alpha)-positive mammary adenocarcinomas. ONCOGENE 33:5511-5522(2014).

Ansari, M; Poke, G; et al. Genetic heterogeneity in Cornelia de Lange syndrome (CdLS) and CdLS-like phenotypes with observed and predicted levels of mosaicism. JOURNAL OF MEDICAL GENETICS 51:659-668(2014).