ETF1
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Official Full Name
eukaryotic translation termination factor 1
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Overview
This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013] -
Synonyms
ETF1; eukaryotic translation termination factor 1; ERF; RF1; ERF1; TB3-1; D5S1995; SUP45L1; eukaryotic peptide chain release factor subunit 1; protein Cl1; polypeptide chain release factor 1; sup45 (yeast omnipotent suppressor 45) homolog-like 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
ETF1 involved in several pathways and played different roles in them. We selected most pathways ETF1 participated on our site, such as mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ETF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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mRNA surveillance pathway | SSU72;MSI1;CPSF5;PPP2R3A;PPP2R5E;FIP1L1;PABPC1A;SMG6;PPP2R1B |
ETF1 has several biochemical functions, for example, RNA binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ETF1 itself. We selected most functions ETF1 had, and list some proteins which have the same functions with ETF1. You can find most of the proteins on our site.
Function | Related Protein |
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RNA binding | ALYREF;CPEB1B;RPL7;HSP90B1;RPUSD1;LRPPRC;MIF4GD;YBX1;KHDC3L |
poly(A) RNA binding | RPS10;ZFP326;CSNK1E;HSD17B10;METTL16;CDK11B;DDX49;DDX24;ZNF326 |
protein binding | ZFYVE20;RCOR2;KRIT1;RTKN;UBL4B;GNAQ;DDX23;PAIP2;MAP2K6 |
ribosome binding | EIF5A2;WIBG;CPEB1B;NARG1;C12orf65;EIF2S1B;CPEB2;ETF1A;MTRF1 |
translation release factor activity | GSPT1L;MTRF1;ETF1;GSPT2 |
translation release factor activity, codon specific | ETF1B;MTRF1;MTRF1L;ETF1;ETF1A |
translation termination factor activity |
ETF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ETF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ETF1.
KEAP1; GSPT1; a8k1f4_human; MLF1; PSMD2; IKBKE; TRMT10C; GSPT2; FKBPL; TRAF6; Mphosph9; FGFR1OP; ALB; VCAM1
- Q&As
- Reviews
Q&As (5)
Ask a questionThere may be clinical trials evaluating potential treatments or interventions for ETF1 protein disorders, and individuals and families affected by these disorders can consider participating in such trials.
Symptoms may include muscle weakness, lethargy, hypoglycemia, metabolic acidosis, and in some cases, developmental delays and neurological symptoms.
Yes, prenatal testing through genetic screening can detect mutations in the ETF1 gene, allowing for early intervention and management.
Diagnosis typically involves biochemical testing, genetic testing, and metabolic screening to identify abnormalities in fatty acid metabolism.
Yes, ETF1 protein disorders can affect individuals of all ages, from newborns to adults, and may present with different symptoms at different stages of life.
Customer Reviews (3)
Write a reviewWhat sets this protein apart is the outstanding technical support provided by the manufacturer.
Its versatility allows me to explore its diverse roles in various biochemical and biological processes accurately.
The ETF1 Protein is of exceptional quality and is precisely tailored to meet my experimental requirements.
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