ETFDH
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Official Full Name
electron-transferring-flavoprotein dehydrogenase
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Overview
Electron-transferring-flavoprotein dehydrogenase in the inner mitochondrial membrane accepts electrons from electron-transfer flavoprotein which is located in the mitochondrial matrix and reduces ubiquinone in the mitochondrial membrane.The protein is synthesized as a 67-kDa precursor which is targeted to mitochondria and processed in a single step to a 64-kDa mature form located in the mitochondrial membrane.Deficiency in electron-transferring-flavoprotein dehydrogenase have been demonstrated in some patients with type IIglutaricacidemia. -
Synonyms
ETFDH; electron-transferring-flavoprotein dehydrogenase; electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; ETFQO; ETF-QO; ETF dehydrogenase; ETF-ubiquinone oxidoreductase; electron transfer flavoprotein ubiquinone oxidoreductase; MA;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Pig
- Rat
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- His (Fc)
- Avi
- His|SUMO
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ETFDH Related Articles
ETFDH involved in several pathways and played different roles in them. We selected most pathways ETFDH participated on our site, such as Metabolism, Respiratory electron transport, Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., which may be useful for your reference. Also, other proteins which involved in the same pathway with ETFDH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | GPHNA;APOEB;ALDH9A1A.2;CDK19;NEU3;ABHD14B;SULT1ST6;GLB1L;CBLC-1 |
| Respiratory electron transport | FAM36A;SURF1;NDUFAF3;COX16;TACO1;C2orf56;ETFB;LRPPRC;NDUFAF5 |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | FAM36A;NDUFAF7;C2orf56;NDUFAF2;UCP2;COX11;ETFA;ATP5S;UCP3 |
| The citric acid (TCA) cycle and respiratory electron transport | ETFB;COX14;TIMMDC1;PDK3B;ETFDH;ADHFE1;C2orf56;NDUFAF6;NDUFAF3 |
ETFDH has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, electron carrier activity, electron-transferring-flavoprotein dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ETFDH itself. We selected most functions ETFDH had, and list some proteins which have the same functions with ETFDH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 4 iron, 4 sulfur cluster binding | ISCA1;ACO1;EXO5;DDX11;NFU1;NDUFS8B;RSAD1;POLE;MOCS1 |
| electron carrier activity | COX5A;GSR;SH3BGRL3;NDUFS1;ACOX1;XDH;ACOX3;IDH3B;NDUFA12 |
| electron-transferring-flavoprotein dehydrogenase activity | AIFM2;ETFDH |
| flavin adenine dinucleotide binding | TXNRD3;GSR;FMO3;DMGDH;SQLEA;MTRR;ETFA;ACOX2;TXNRD2 |
| metal ion binding | ACSM5;ANKMY2;NUBP2;PPM1L;FHL1B;PRICKLE1B;ZNF48;NR1D4A;HMOX2 |
| oxidoreductase activity | CYP1C2;SEPW1;CYP11C1;AOX3L1;CYP2P9;ZADH2;PYCR1A;CYB5RL;HSD3B6 |
| oxidoreductase activity, oxidizing metal ions with flavin as acceptor | |
| quinone binding | HHIPL2;AOC1;AMOTL1;VKORC1;HHIPL1;ABP1;AOC3;NDUFS7;SQRDL |
| ubiquinone binding | ETFDH;SDHD;DHODH;SDHDA;SDHB;SDHDB |
ETFDH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ETFDH here. Most of them are supplied by our site. Hope this information will be useful for your research of ETFDH.
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