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EXO1

Official Full Name

exonuclease 1
Overview

This gene encodes a protein with 5 to 3 exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative sp
Synonyms

EXO1; exonuclease 1; Exo 1; Exo I; EXO1_HUMAN; ExoI; Exonuclease I; Exonuclease1; ExonucleaseI; HEX 1; HEX1; hExo 1; hExo I; hExo1; hExoI; Rad2 nuclease family member homolog of S. cerevisiae exonuclease 1; mExo1; Msa; 5730442G03Rik;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	EXO1-13H	Recombinant Human EXO1 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	EXO1-12H	Recombinant Human EXO1 protein, His-tagged	E.coli	His		Inquiry
Human	EXO1-580HCL	Recombinant Human EXO1 cell lysate		N/A		Inquiry
Mouse	EXO1-5367M	Recombinant Mouse EXO1 Protein	Mammalian Cell	His		Inquiry
Mouse	EXO1-2892M	Recombinant Mouse EXO1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	EXO1-2892M-B	Recombinant Mouse EXO1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	Exo1-714R	Recombinant Rat Exo1 Protein, His-tagged	E.coli	His	Met1~Ile250	Inquiry
Zebrafish	EXO1-12637Z	Recombinant Zebrafish EXO1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
EXO1 Related Articles

EXO1 involved in several pathways and played different roles in them. We selected most pathways EXO1 participated on our site, such as Mismatch repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with EXO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Mismatch repair	RPA4;RFC2;MLH3;PCNA;SSBP1;PMS2;LIG1;RFC3;EXO1

EXO1 has several biochemical functions, for example, 5-3 exodeoxyribonuclease activity, 5-3 exonuclease activity, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EXO1 itself. We selected most functions EXO1 had, and list some proteins which have the same functions with EXO1. You can find most of the proteins on our site.

Function	Related Protein
5-3 exodeoxyribonuclease activity	DCLRE1C;EXO1;DCLRE1A
5-3 exonuclease activity	DOM3Z;CPSF3;FAN1;DCLRE1C;XRN2;FEN1;POLN;DXO;EXO1
DNA binding	SMUG1;THRAA;OLIG2;ZNF560;UBN2;SUPV3L1;NPAS4A;TFEC;ZNF333
RNA-DNA hybrid ribonuclease activity	EXO1;FEN1;RNASEH2C;RNASEH2A;APEX1;RNASEH2B;RNASEH1
double-stranded DNA 5-3 exodeoxyribonuclease activity
exonuclease activity	REXO1;ISG20;REX1;RAD9;AEN;REXO4;EXOSC9;TDP1;REXO1L1
flap endonuclease activity
metal ion binding	FOXP1;COL9A1;SMPD3;ZFP473;RNF169;ZBTB2A;MT4;ZFP580;PRDM8B
protein binding	GTF2H1;ZMYM5;PFDN5;KLHL20;ITGB1BP2;TUFM;MT1A;C17orf59;CNOT3
single-stranded DNA 5-3 exodeoxyribonuclease activity	DEM1;EXO5;EXO1
structure-specific DNA binding	ENDOV;TET1;SETMAR;TDG;EXO1

EXO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EXO1.

RBBP8; CD14; CFTR; COMT; YWHAB; Tmem109; LLGL2; KLC3; ACTR5; MYEF2; RPA2; H2AFX

Upton, DC; Unniraman, S; et al. Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS :-(2011).

Eccleston, J; Yan, C; et al. Mismatch Repair Proteins MSH2, MLH1, and EXO1 Are Important for Class-Switch Recombination Events Occurring in B Cells That Lack Nonhomologous End Joining. JOURNAL OF IMMUNOLOGY 186:2336-2343(2011).