EXOC3
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Official Full Name
exocyst complex component 3
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Overview
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. -
Synonyms
EXOC3; exocyst complex component 3; SEC6 like 1 (S. cerevisiae) , SEC6L1; Sec6p; EXOC 3; Exocyst complex component Sec 6; Exocyst complex component Sec6; rSec 6; Sec 6; Sec 6 homolog; Sec 6p; Sec6; SEC6 L1; SEC6 like 1; Sec6 protein; SEC6L1; SEC6-like 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
EXOC3 involved in several pathways and played different roles in them. We selected most pathways EXOC3 participated on our site, such as Arf6 trafficking events, Assembly of the primary cilium, Cargo trafficking to the periciliary membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with EXOC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arf6 trafficking events | CHRM2;DNM2;SPAG9;JUP;CTNND1;PTBP3;CLTC;ADRB2;EXOC6 |
| Assembly of the primary cilium | C11orf60;DYNC1I2;CC2D2A;EXOC1;CCT2;BBS1;SDCCAG8;TTC8;CLASP1 |
| Cargo trafficking to the periciliary membrane | CCT8;LZTFL1;CCT2;CCT3;PKD1;UNC119B;PKD2;CNGA5;CNGA2 |
| Insulin Pathway | EXOC1;EXOC5;EXOC3;EXOC6;DOK1;GRB14;GRB10 |
| Insulin processing | PCSK2;KIF5A;KIF5B;SLC30A5;CPE;EXOC3;EXOC5;EXOC6;EXOC8 |
| Membrane Trafficking | COPB1;BLOC1S3;PICALMA;NECAP1;TPD52L1;TPD52;MYO6;TFR1B;SEC22A |
| Metabolism of proteins | DMBT1;MTX2;IGFBP4;TRAPPC10;COX17;ATPBD4;FBXW4;SAMM50;ADAMTS1 |
| Organelle biogenesis and maintenance | GABPB1;MKKS;EXOC6;UNC119B;NPHP1;MRPL50;ATAT1;MRPL47;MRPS31 |
EXOC3 has several biochemical functions, for example, SNARE binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EXOC3 itself. We selected most functions EXOC3 had, and list some proteins which have the same functions with EXOC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SNARE binding | VAMP1;CAPN10;SYBL1;UVRAG;VAMP8;YKT6;STX11B.2;EXOC3;STX7 |
| protein binding | THEG;MAGEF1;PRKDC;GAGE1;HSPH1;SEPT7;OSTA;SPSB1;MED23 |
EXOC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EXOC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EXOC3.
EGFR; MYC; LAPTM4B; Poc1b; BUB3; MLH1; dedA3; pi3p; Birc6; SNW1
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